Bone-like inducing grafts: in vivo and micro-CT analysis

L'abstract è presente nell'allegato / the abstract is in the attachmen

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

Dietary habits have been strongly linked to the maintenance of intestinal epithelium homeostasis, whose alteration may contribute to the pathogenesis of inflammatory diseases and cancer. Polyphenols are among those dietary components suggested to be beneficial for gut health. Within a balanced Mediterranean type diet, a good portion of ingested polyphenols comes from olives and extra virgin olive oil (EVOO). Most of them reach the intestine, where they may be directly absorbed or metabolized under absorption. Others undergo an extensive gastrointestinal biotransformation, producing various metabolites that retain the potential beneficial effect of the parent compounds, or exert a more efficient biological action themselves. Ingested EVOO polyphenols (EVOOP) and their metabolites will be particularly concentrated in the intestinal lumen, where they might exert a significant local action. In this review we summarize the few studies that investigated the effect of EVOOP at the intestinal level, focusing on the possible mechanism of action in relation to their interaction with the microbiota, and their ability to potentially modulate the oxidative status of the intestinal epithelial layer, inflammation and immune response

Design and construction of a distributed sensor NET for biotelemetric monitoring of brain energetic metabolism using microsensors and biosensors

Neurochemical pathways involved in brain physiology or disease pathogenesis are mostly unknown either in physiological conditions or in neurodegenerative diseases. Nowadays the most frequent usage for biotelemetry is in medicine, in cardiac care units or step-down units in hospitals, even if virtually any physiological signal could be transmitted (FCC, 2000; Leuher, 1983; Zhou et al., 2002). In this chapter we present a wireless device connected with microsensors and biosensors capable to detect real-time variations in concentrations of important compounds present in central nervous system (CNS) and implicated in brain energetic metabolism (Bazzu et al., 2009; Calia et al., 2009)

Divergent acute and enduring changes in 50-kHz ultrasonic vocalizations in rats repeatedly treated with amphetamine and dopaminergic antagonists: new insights on the role of dopamine in calling behavior

Background: Rats emit 50-kHz ultrasonic vocalizations (USVs) in response to non-pharmacological and pharmacological stimuli, with addictive psychostimulants being the most effective drugs that elicit calling behavior in rats. Earlier investigations found that dopamine D1-like and D2-like receptors modulate the emission of 50-kHz USVs stimulated in rats by the acute administration of addictive psychostimulants. Conversely, information is lacking on how dopamine D1-like and D2-like receptors modulate calling behavior in rats that are repeatedly treated with addictive psychostimulants. Methods: We evaluated the emission of 50-kHz USVs in rats repeatedly treated (×5 on alternate days) with amphetamine (1 mg/kg, i.p.), either alone or together with: i) SCH 23390 (0.1-1 mg/kg, s.c.), a dopamine D1 receptor antagonist, ii) raclopride (0.3-1 mg/kg, s.c.), a selective dopamine D2 receptor antagonist, or iii) a combination of SCH 23390 and raclopride (0.1 + 0.3 mg/kg, s.c.). Calling behavior of rats was recorded following pharmacological treatment, as well as in response to the presentation of amphetamine-paired cues and to amphetamine challenge (both performed 7 days after treatment discontinuation). Results: Amphetamine-treated rats displayed a sensitized 50-kHz USV emission during repeated treatment, as well as marked calling behavior in response to amphetamine-paired cues and to amphetamine challenge. Antagonism of D1 or D2 receptors either significantly suppressed or attenuated the emission of 50-kHz USVs in amphetamine-treated rats, with a maximal effect after synergistic antagonism of both receptors. Conclusions: These results shed further light on how dopamine transmission modulates the emission of 50-kHz USVs in rats treated with psychoactive drugs

Addressing some critical aspects of the BepiColombo MORE relativity experiment

The Mercury Orbiter radio Science Experiment (MORE) is one of the experiments on-board the ESA/JAXA BepiColombo mission to Mercury, to be launched in October 2018. Thanks to full on-board and on-ground instrumentation performing very precise tracking from the Earth, MORE will have the chance to determine with very high accuracy the Mercury-centric orbit of the spacecraft and the heliocentric orbit of Mercury. This will allow to undertake an accurate test of relativistic theories of gravitation (relativity experiment), which consists in improving the knowledge of some post-Newtonian and related parameters, whose value is predicted by General Relativity. This paper focuses on two critical aspects of the BepiColombo relativity experiment. First of all, we address the delicate issue of determining the orbits of Mercury and the Earth-Moon barycenter at the level of accuracy required by the purposes of the experiment and we discuss a strategy to cure the rank deficiencies that appear in the problem. Secondly, we introduce and discuss the role of the solar Lense-Thirring effect in the Mercury orbit determination problem and in the relativistic parameters estimation.Comment: 29 pages, 5 figures. Presented at the Seventh International Meeting on Celestial Mechanics, San Martino al Cimino (Viterbo, Italy), 3-9 September 201

the urgent need of new mood stabilizers the promising results of memantine

Giulia Serra1,2, Francesca Demontis3 and Gino Serra4* 1Clinical and Research fellow, Child Neuropsychiatry, Department of Neuroscience, I.R.C.C.S. Children Hospital Bambino Gesu, Rome, Italy. 2NESMOS Department, Sant'Andrea Hospital, Sapienza University, Rome Italy 3International Consortium for Bipolar Disorder Research, McLean Hospital, Belmont (MA), USA 4Dipartimento di Scienze Biomediche, University of Sassari, Ital

A test of gravitational theories including torsion with the BepiColombo radio science experiment

The Mercury Orbiter radio Science Experiment (MORE) is one of the experiments on-board the ESA/JAXA BepiColombo mission to Mercury, to be launched in October 2018. Thanks to full on-board and on-ground instrumentation performing very precise tracking from the Earth, MORE will have the chance to determine with very high accuracy the Mercury-centric orbit of the spacecraft and the heliocentric orbit of Mercury. This will allow to undertake an accurate test of relativistic theories of gravitation (relativity experiment), which consists in improving the knowledge of some post-Newtonian and related parameters, whose value is predicted by General Relativity. This paper focuses on two critical aspects of the BepiColombo relativity experiment. First of all, we address the delicate issue of determining the orbits of Mercury and the Earth-Moon barycenter at the level of accuracy required by the purposes of the experiment and we discuss a strategy to cure the rank deficiencies that appear in the problem. Secondly, we introduce and discuss the role of the solar Lense-Thirring effect in the Mercury orbit determination problem and in the relativistic parameters estimation

Shape-Memory Polymers in Dentistry: Systematic Review and Patent Landscape Report

To perform a systematic review (SR) of existing literature and a patent landscape report (PLR) regarding the potential applications of shape-memory polymers (SMPs) in dentistry