Графическое сопровождение международной конференции, посвященной изучению творчества японского писателя Акутагава Рюноске

Графическое сопровождение мероприятия на Восточном факультете в 2018 годуVisual identity of the event at the Eastern faculty in 201

Recent developments in genetics and medically assisted reproduction : from research to clinical applications

Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.Peer reviewe

Petrochanteric fractures: cement augmentation

Implant augmentation aims to increase the implant to bone surface and to reduce the stresses on the trabecular structures. Augmentation is performed by the injection of small amounts of PMMA through the implant. The additional stability has been shown in biomechanical and clinical studies on Dynamic Hip Screw (DHS) augmentation and on proximal femoral nail augmentation. The decision for augmentation is made after implantation of the helical blade and is based on the clinical judgement of the bone strength of the femoral head during blade insertion by the surgeon. The only contra-indication for proximal femoral nail augmentation is a perforation of the femoral head by the Kirschner-wire or by the helical blade because this would lead to cement leakage in the hip joint. Until now, there is only limited clinical experience. All fractures showed callus formation, no osteonecrosis of the femoral head or lysis around the blade was noticed and no implant migration like cut- out or cut-through was seen. The data suggest that the rate of complications directly related to implant augmentation is very low when the technique is applied correctly.status: publishe

Intramedullary fixation of proximal humerus fractures: do locking bolts endanger the axillary nerve or the ascending branch of the anterior circumflex artery? A cadaveric study

BACKGROUND: Proximal humerus fractures are one of the most common fractures. Intramedullary locked nailing is becoming a popular alternative treatment, especially for easier fracture patterns. Although axillary nerve injury has been reported, no study has compared the safety of the proximal locking options relative to the axillary nerve and the ascending branch of the anterior circumflex artery. METHOD: Six different commercially available proximal humeral nails were implanted in 30 shoulders of 18 cadavers. After fluoroscopically guided implantation the shoulders were carefully dissected and the distance between the locking screws, the axillary nerve and the ascending branch of the anterior circumflex artery was measured. RESULTS: The course of the axillary nerve varies. A mean distance of 55.8 mm (SD = 5.3) between the lateral edge of the acromions and the axillary nerve at the middle of the humerus in a neutrally rotated position was observed. The minimum distance was 43.4 mm, the maximum 63.9 mm. Bent nails with oblique head interlocking bolts appeared to be the most dangerous in relation to the axillary nerve. The two designs featuring such a bend and oblique bolt showed a mean distance of the locking screw to the axillary nerve of 1 mm and 2.7 mm respectively Sirus (Zimmer(®)) and (Stryker(®)) T2 PHN (Proximal Humeral Nail)). Regarding the ascending branch of the anterior circumflex artery, there was no difference between the nails which have an anteroposterior locking option. CONCLUSION: It is of great importance for surgeons treating proximal humerus fractures to understand the relative risk of any procedure they perform. Since the designs of different nailing systems risk damaging the axillary nerve and ascending branch, blunt dissection, the use of protection sleeves during drilling and screw insertion, and individual risk evaluation prior to the use of a proximal humeral nail are advocated

Intramedullary fixation of proximal humerus fractures: do locking bolts endanger the axillary nerve or the ascending branch of the anterior circumflex artery? A cadaveric study

BACKGROUND: Proximal humerus fractures are one of the most common fractures. Intramedullary locked nailing is becoming a popular alternative treatment, especially for easier fracture patterns. Although axillary nerve injury has been reported, no study has compared the safety of the proximal locking options relative to the axillary nerve and the ascending branch of the anterior circumflex artery. METHOD: Six different commercially available proximal humeral nails were implanted in 30 shoulders of 18 cadavers. After fluoroscopically guided implantation the shoulders were carefully dissected and the distance between the locking screws, the axillary nerve and the ascending branch of the anterior circumflex artery was measured. RESULTS: The course of the axillary nerve varies. A mean distance of 55.8 mm (SD = 5.3) between the lateral edge of the acromions and the axillary nerve at the middle of the humerus in a neutrally rotated position was observed. The minimum distance was 43.4 mm, the maximum 63.9 mm.Bent nails with oblique head interlocking bolts appeared to be the most dangerous in relation to the axillary nerve. The two designs featuring such a bend and oblique bolt showed a mean distance of the locking screw to the axillary nerve of 1 mm and 2.7 mm respectively Sirus (Zimmer(R)) and (Stryker(R)) T2 PHN (Proximal Humeral Nail)).Regarding the ascending branch of the anterior circumflex artery, there was no difference between the nails which have an anteroposterior locking option. CONCLUSION: It is of great importance for surgeons treating proximal humerus fractures to understand the relative risk of any procedure they perform. Since the designs of different nailing systems risk damaging the axillary nerve and ascending branch, blunt dissection, the use of protection sleeves during drilling and screw insertion, and individual risk evaluation prior to the use of a proximal humeral nail are advocated.status: publishe

Development, Implementation and preliminary results of a clinical pathway "prevention of recurrent fragility fractures"

status: publishe

Symptomatic adenomyomatosis of the gallbladder: report of a case

Adenomyomatosis of the gallbladder is a benign and degenerative condition of the gallbladder, characterized by proliferation of the mucosa of the gallbladder wall, forming invaginations and diverticula, penetrating a thickened muscular layer: the so-called Rokitansky-Aschoff sinuses (RAS). Most of the patients with adenomyomatosis remain asymptomatic. Hence adenomyomatosis is usually an incidental finding, either on ultrasonography performed for the detection of stones or by histologic examination of surgical gallbladder specimens. Only occasionally does adenomyomatosis not associated with cholelithiasis cause right upper quadrant pain. We report a case of symptomatic adenomyomatosis of the gallbladder. Clinical findings, etiology, diagnosis and therapy are discussed.status: publishe

Finite element models can aid in identifying suitable patients for femoroplasty of metastatic lesions

status: publishe