Relatively high levels of serum adiponectin in obese women, a potential indicator of anti-inflammatory dysfunction: Relation to sex hormone-binding globulin

It is unclear whether serum adiponectin concentrations diminish linearly with increasing adiposity and, if not, which factors codetermine this association. These issues were investigated cross-sectionally in 1188 men and women, representative of middle-aged and elderly Turkish adults. Serum total adiponectin was assayed by ELISA. Serum adiponectin values in men, though declining significantly in transition from the bottom to the mid tertile of body mass index (BMI) and waist circumference (WC), were similar in the two respective upper tertiles. In women, serum adiponectin concentrations were not significantly different in any tertile of these indices, were significantly correlated with BMI or WC within the low tertiles and not within the two higher tertiles. In a linear regression analysis for WC (or BMI) in a subset of the sample in which serum sex hormone-binding globulin (SHBG) was available and which additionally comprised adiponectin, fasting insulin and other confounders, only insulin and, in women SHBG, were significantly associated, but not adiponectin. In linear regression analyses for covariates of adiponectin in two models comprising 12 variables, insulin and SHBG concentrations were significantly associated in both genders though not BMI. Whereas in men HDL-cholesterol and CRP were covariates of adiponectin (both p<0.01), SHBG and apolipoprotein B positively associated in women (p<0.001), independent of BMI and fasting insulin levels

Lithium intoxication related multiple temporary ecg changes: A case report

Lithium is a widely used mood stabilizer, which may cause cardiac side effects. In this article, we present the case of a 39-year-old woman who had presented with pre-syncope and developed multiple ECG abnormalities that are caused by lithium intoxication and are disappeared after hemodialysis

Echocardiographic evalution of the left ventricular diastolic functions in rheumatoid arthritis

YÖK Tez No: 225113Giriş: Biz çalışmamızda geleneksel Doppler ve yeni bir ekokardiyografik teknik olan doku Doppler görüntüleme (DDG) yöntemini kullanarak RA hastalarında sol ventrikül diyastolik fonksiyonlarını değerlendirdik.Yöntem: Çalışmamıza 46 RA hastası ve 31 sağlıklı birey dahil edildi. Hastalık süresi 0 ile 12 yıl arasında idi (ortalama 4,2±4,3 / yıl). Tüm hastalar ve kontrol grubu M-mode, 2-D, geleneksel Doppler ekokardiyografi ve DDG ile değerlendirildi.Bulgular: Kontrol grubu ile karşılaştırıldığında, RA grubu bazal klinik ve ekokardiyografik parametreler, sol atriyum çapı, sol ventrikül çapları, sol ventrikül ejeksiyon fraksiyonu, sol ventrikül duvar kalınlıkları her iki grupta benzerdi. Geleneksel Doppler mitral akım parametrelerinden, erken diyastolik akım velositesi (E) (p = 0,001), geç diyastolik akım velositesi (A) (p = 0,03) ve deselerasyon zamanı (DZ) (p = < 0,001) değerleri kontrol grubuna göre RA hastalarında daha yüksekti. Kontrol grubuna göre RA grubunda E/A oranı daha düşük bulundu (p = < 0,001). Doku Doppler görüntüleme parametrelerinden mitral anuler erken diyastolik hız dalgası (Em) kontrol grubuna göre RA grubunda daha düşük bulundu (p = 0,01). Mitral anuler geç diyastolik hız dalgası (Am) kontrol grubu ile karşılaştırıldığında RA grubunda daha yüksek bulundu (p = 0,007).Sonuç: Yaş ve cinsiyet olarak benzer özellikte olan RA hastaları ile kontrol grubu karşılaştırıldığında, RA hastalarında geleneksel Doppler ve doku Doppler parametrelerinin bozuk olduğu saptandı.Background and aim: The aim of this study was to evaluate LVDF in patients with RA, analyzing conventional Doppler and tissue Doppler echocardiographic imaging (TDI) which is a new echocardiographic application.Method: Fourty-six patients with RA and 31 healthy persons were included in this study. Duration of disease ranged from 0 to 12 years (mean 4,2 ± 4,3 / years). All patients and the control group were evaluated by M-mode, two-dimensional, conventional Doppler echocardiography and TDI.Results: When compared with controls, the RA group showed that basal clinic and echocardiographic parameters, left atrial diamater, left ventriculer diamaters, left ventriculer ejection fraction, left ventricular wall thicknesses of these two groups were similar. Among conventional Doppler transvalvular mitral flow parameters, early diastolic flow velocity (E) (p = 0,001), late diastolic flow velocity (A) (p = 0,03) and deceleration time (DT) (p = < 0,001) values were higher in patients with RA than that in the control group. E/A ratio was found to be lower in patients with RA than that in the control group (p = < 0,001). Mitral annular early diastolic velocity (Em), among TDI parameters, was found to be lower in patients with RA than that in the control group (p = 0,01). Mitral annular late diastolic velocity (Am) was found to be higher in RA patients compared with that in the control group (p = 0,007).Conclusion: A comparison between age and sex of RA patients and healthy individuals revealed that left ventricular conventional Doppler and TDI parameters of RA patients were impaired

Infarct-related artery filled with thrombus cleared completely after tirofiban therapy

WOS: 000302895000014The treatment of acute coronary syndrome patients with high thrombus burden is difficult. Percutaneous coronary interventions increase the frequency of distal embolization in these patients. Glycoprotein Ilb/IIla inhibitors are effective anti-platelet agents and they can be very helpful in such cases. Herein, we present the impact of tirofiban infusion on an infarct-related artery with high thrombotic burden. The thrombus cleared completely without coronary angioplasty

Short and long term follow-up results of patients who are implanted with R-stent: A single center experience

World Congress of Cardiology -- MAY 18-21, 2008 -- Buenos Aires, ARGENTINAWOS: 000259224800392…World Heart Federat, Argentine Soc Cardiol, Argentine Federat Cardio

The neuroprotective effects of eritropoietin in the central nervous system [Eritropoetinin santral sinir sistemindeki'deki nöroprotektif etkileri]

Erythropoietin (Epo) acts primarily to stimulate erythroid cell production by supporting the survival, proliferation and differentiation of erythroid progenitor cells but It is now widely known that erythropoietin does not only affect the haematopoietic system. Erythropoietin has a dominant role for neuroprotection, neurogenesis, and acting as a neurotrophic factor in the central nervous system. A wide variety of experimental studies have shown that Epo and its receptor are expressed in the nervous system also Epo exerts remarkable neuroprotection in cell culture and animal models of nervous system disorders. The discovery that erythropoietin exerts neuroprotective properties has opened new therapeutic avenues. In this review, we summarize the current knowledge on the neuroprotective properties of Epo. © 2012 Düzce Medical Journal

Myocardial performance index in patients with dipper and nondipper hypertension

WOS: 000339169500006PubMed: 24847725Background The aim of this study was to evaluate the relationship between left ventricular (LV) myocardial performance index (MPI) and nondipper pattern in hypertensive patients. Methods Between June 2012 and November 2012, patients admitted to the Cardiology Department of Duzce University Faculty of Medicine and diagnosed previously with essential hypertension were included in the study. Patients were divided into two groups, nondippers and dippers, using ambulatory blood pressure measurement. All patients were evaluated by two-dimensional and Doppler echocardiography. LV MPI was calculated from tissue Doppler imaging parameters. Results There was no significant difference between the two groups in the proportion of each class of antihypertensive medications. Dippers and nondippers had similar age, BMI, lipid profiles, and smoking status. The MPI value was significantly higher in nondippers than in dippers, and was correlated negatively with the rate of systolic and diastolic blood pressure fall at night (P < 0.001). Conclusion Our study showed that MPI is disturbed in patients with nondipper hypertension. MPI may be used in the diagnosis and follow-up of global LV dysfunction in patients with a nondipper pattern, but further prospective studies are needed. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

A Rare Combination: Myocardial Infarction and Cerebral Ischemia

Miyokard infarktüsü (Mİ), kalbin bir bölümüne kan akımının azalmasından kaynaklanan kalp kası hücrelerinin ölümüdür. Kan akımının azalması, kalbin oksijen ihtiyacını artırır. Eğer tedavi edilmez ise kalp kasında hasara ve ölüme neden olabilir. Serebral iskemi, beyne yetersiz kan akımı sonucu beyinde oluşan metabolik hasarı ifade eder. Serebral hipoksi sonrasında, serebral iskemi dediğimiz ilgili beyin dokusunun ölümü olur. Serebral iskeminin belirtileri arasında bilinç kaybı (somnolansdan stupora kadar gidebilen), körlük, denge problemleri, güçsüzlük, kardiyopulmoner arrest ve geri dönüşümsüz beyin hasarı sayılabilir. Mİ ve serebral iskeminin birarada gözlenmesi nadir olup her ikisinin birlikte gözlendiği bu olguyu son literatür bilgileri eşliğinde değerlendirmeyi amaçladık.Myocardial infarction (MI) is death of heart cells due to the decreased blood flow to a part of the heart. Reduction in blood flow increases the oxygen demand of the heart and if it left untreated for a sufficient period of time, can cause damage or death of heart muscle tissue. Cerebral ischemia,represents metabolic damage in the brain as a result of insufficient blood flow. Cerebral hypoxia leads to death of brain tissue that named cerebral infarction. Symptoms of brain ischemia can include unconsciousness (from somnolance to stupor), blindness, coordination problems, body weakness, cardiorespiratory arrest and irreversible brain damage. Observation of cerebral ischemia and MI are a rare combination. Combination of MI and cerebral ischemia is a rare situation we evaluated the case in light of recent literature

Short and long term results of percutaneous coronary intervention in patients older than 80 years old

World Congress of Cardiology -- MAY 18-21, 2008 -- Buenos Aires, ARGENTINAWOS: 000259224800390…World Heart Federat, Argentine Soc Cardiol, Argentine Federat Cardio