SERUM MOTS-C LEVELS REMAIN UNCHANGED IN PATIENTS WITH PREECLAMPSIA

Objectives: Mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c) is a mitochondrial derived peptide which has beneficial effects on muscle metabolism, insulin sensitivity, weight regulation, and bone mineral density. This study aims to investigate whether serum levels of MOTS-c are altered in patients with preeclampsia. Material and methods: This is cross sectional a case-control study of 30 patients with uncomplicated pregnancy, 30 patients with mild preeclampsia and 30 patients with severe preeclampsia that were admitted to the study center between June 2020 and January 2021. Results: When compared to the healthy controls and patients with mild preeclampsia, maternal smoking was significantly more frequent, systolic and diastolic blood pressures were significantly higher and platelet count was significantly lower in patients with severe preeclampsia (p = 0.045, p = 0.0001, p = 0.0001 and p = 0.024 respectively). Serum MOTS-c concentrations were statistically similar in healthy controls, mild and severe preeclampsia patients (159.1 ± 28.7 ng/mL vs 129.6 ± 54.7 ng/mL vs 146.4 ± 48.3, p = 0.166). When compared to the healthy controls, systolic and diastolic blood pressures were significantly higher and platelet count was significantly lower in patients with late onset preeclampsia (p = 0.0001, p = 0.0001 and p = 0.022 respectively). Healthy controls and patients with early and late onset preeclampsia were statistically similar with respect to MOTS-c levels (159.1 ± 28.7 ng/mL vs 126.7 ± 56.9 vs 153.7 ± 39.8, p = 0.102). Conclusions: This study failed to detect any significant relationship between MOTS-c and preeclampsia. Large scale research is needed to clarify if MOTS-c is a novel biomarker for preeclampsia and therapeutic target for preeclampsia patients

Endoscopic vs external dacryocystorhinostomy-comparison from the patients’ aspect

<b>AIM:</b> To compare the success and complication rates, duration of surgeries and clinical comfort after endoscopic dacryocystorhinostomy (END-DCR) or external dacryocystorhinostomy (EXT-DCR).<b>METHODS:</b> Fifty patients who underwent EXT- or END-DCR between January 2010-2012 were involved in the study. A questionnaire was applied to patients preoperatively, and postoperatively. Subjective success was defined by absence of epiphora, objective success by a normal nasolacrimal lavage and a positive functional endoscopic dye test (FEDT). Postoperative pain and cosmetic result of surgery were interpreted by the patients, who were also asked whether they would offer this surgery to a friend or would prefer this surgery once more if necessary.<b>RESULTS:</b>Twenty-five patients underwent END-DCR and 25 underwent EXT-DCR. Mean duration of surgeries were 35min both for EXT-DCR (30-50) and END-DCR (35-50) (<i>P=</i>0.778). Intraoperative bleeding were documented in 48% of EXT-DCR and 4% of END-DCR cases (<i>P&lt;</i>0.001). In total 96% of EXT-DCR and 100% of END-DCR patients had subjective success. Objective success was 100% in each group. There was no significant difference between the epiphora scorings and FDDT results in postoperative visits among the groups.END-DCR group reported less pain in first week and month (<i>P&lt;</i>0.05, <i>P&lt;</i>0.05). More patients in END-DCR group were happy with the cosmetic result in first week and month (<i>P&lt;</i>0.001, <i>P&lt;</i>0.001). More patients in END-DCR group offered this surgery to a friend (<i>P&lt;</i>0.001). All patients in END-DCR group preferred this surgery once more if necessary, only 48% in EXT-DCR preferred the same method (<i>P&lt;</i>0.001).<b>CONCLUSION:</b> Although both END- and EXT-DCRs provide satisfactory outcomes with similar objective and subjective success rates, we demonstrated that the endonasal approach caused significantly less pain in early postoperative period than the external approach. Clinical comfort defined by the patients was quite higher in END-DCR group, in which patients mainly were pleased to encounter a sutureless surgical area

A Rare Location of Angiofibroma in the Inferior Turbinate in Young Woman

Introduction Juvenile nasopharyngeal angiofibroma is a rare benign neoplasm in the nasopharynx. The tumor tends to be locally aggressive and is typically seen in adolescent boys. Extranasopharyngeal angiofibromas have been reported sporadically in the literature. They most commonly originate from the maxillary sinus., Objectives A 26-year-old woman was referred to our clinic with intermittent epistaxis from the right nasal passage for the previous 2 months. Maxillofacial magnetic resonance imaging showed a lobular, contoured mass originating from the right inferior turbinate and hanging in the right nasal cavity, with dense contrast enhancement denoting hypervascularity., Resumed Report Vascular feeding of the mass was seen from the right internal maxillary artery with angiography, and this branch was embolized. On the following day, the patient underwent transnasal endoscopic excision of the mass. An approximately 3-cm-diameter mass was excised by partial turbinectomy, and the posterior edge of the remaining turbinate was cauterized., Conclusion Extranasopharyngeal angiofibromas are rarely seen, and the inferior turbinate is an extremely rare location for them. This young woman is the first case reported in the English literature of angiofibroma originating from the inferior turbinate. We should consider these neoplasms can be found in female, nonadolescent patients with extranasopharyngeal localization, and we should not perform biopsy because of its massive bleeding.PubMedScopu

Generation recombination suppression via depletion engineered heterojunction for alternative substrate MWIR HgCdTe infrared photodetectors

We show suppression of generation-recombination dark current that leads to an increase in the operating temperature nearly 40K (from similar to 85K to similar to 125 K, tau(SRH) = 200 ns) with diffusion limited performance of alternative substrate multiwafer infrared HgCdTe infrared photodetectors with a cut-off wavelength of 5 mu m. Enhancement has been achieved by shifting the depletion region into an n type wide bandgap material. An in-house numerical model, which solves Poisson, continuity, and current equations for electrons and holes, is utilized for high precision in electrical and optical characterization of the detector. Composition and doping levels are optimized so that the collection of photo-generated carriers is not disturbed and the quantum efficiency is kept high. Published by AIP Publishing

Turkish Journal of Sport and Exercise Soccer players efficacy belief, CSAI-2C, SCAT perception and success comparison *

Abstract The purpose of this study was to compare to relationships anxiety, efficacy beliefs and perception of success that are playing football at 11-13. Youth and Sports Club Soccer Branch of Anadolu University U-13 players were participated in this study. Measurements were applied to athletes two times selection of Anadolu University. Competition State Anxiety Inventory -Child Version-2 (CSAI-2C), Competition Trait Anxiety Inventory-Child Form (SCAT-C), Self-Efficacy (SES), Perception of Success -Children&apos;s Version (POSQ-CH) is used to collection data. Descriptive statistics and Pearson Moment Correlation analysis were used to calculate data. Between the first and second measurement after the analysis, SCAT-C and a positive correlation between somatic anxiety (r =.465, p &lt;0.01), Scat Self-Efficacy with negative (r = -.455, p &lt;0.01), Cognitive SCAT and a positive correlation between anxiety (r =.706, p &lt;0.01), Scat and a positive correlation between somatic anxiety (r =.722, p &lt;0.01), there was a negative correlation among self-efficacy and SCAT. As a result, there were some significant relationships between competitive state anxiety and state competitive with goal settings

Stability Formulation for Integrated Opto-mechanic Phase Shifters

Abstract Stability of opto-mechanical phase shifters consisting of waveguides and non-signal carrying control beams is investigated thoroughly and a formula determining the physical limitations has been proposed. Suggested formulation is not only beneficial to determine physical strength of the system but also advantageous to guess the response of the output to the fabrication errors. In the iterative analysis of cantilever and double-clamped beam geometrical configurations, the stability condition is revealed under the strong inter-dependence of the system parameters such as input power, device length and waveguide separation. Numerical calculations involving effective index modifications and opto-mechanic movements show that well-known cantilever beams are unstable and inadequate to generate φ = 180° phase difference, while double-clamped beam structures can be utilized to build functional devices. Ideal operation conditions are also presented in terms of both the device durability and the controllability of phase evolution

Physical Stability Analysis for Optical MEMS Phase Shifters

Stability and switching performance of light force driven opto-mechanical phase shifters are examined and a formula determining the stability condition has been proposed for various structures. The analysis showed that cantilever beams are inadequate to generate 180 phase difference

A comparative design study for MWIR HgCdTe detectors

High performance multi-layer MWIR HgCdTe detector design requires detailed analysis considering the interaction between layers and the nonlinear effects. For this purpose, an in-house numerical model is utilized so that electrical and optical parameters are manipulated to eliminate the undesired performance limits. An ideal detector with perfect crystal quality is expected to have diffusion limited dark current. However, for low operating temperatures (<120K), which is usually the case for the high performance applications, SRH mechanism may dominate dark current especially for alternative substrate detectors and low crystal quality resulting in a short SRH lifetime (similar to 200ns). Here, physical sizes, composition and doping profiles are optimized to suppress generation-recombination (GR) dark current so that cooling burden can be minimized. We numerically achieve similar to 30K (from similar to 85K to similar to 115K) increase on the operating temperature without degrading the system performance parameters for the detection of near room temperature object (300K) by placing a wide bandgap layer inside the bandgap

Partial Laryngectomy with Cricoid Reconstruction: Thyroid Carcinoma Invading the Larynx

Laryngotracheal invasion worsens the prognosis of thyroid cancer and the surgical approach for laryngotracheal invasion is controversial. In this paper, partial full-thickness excision of the cricoid cartilage with supracricoid laryngectomy and reconstruction of existing defect with thyroid cartilage are explained in a patient with papillary thyroid carcinoma invading the thyroid cartilage and cricoid cartilage without intraluminal invasion. Surgical indication should not be established by the site of involvement in thyroid carcinomas invading the larynx, as in primary cancers of the larynx. We think that partial laryngectomy according to the involvement site and the appropriate reconstruction techniques should be used for thyroid cancer invading the larynx

SWIR nightglow radiation detection around room temperature with depletion-engineered HgCdTe on alternative substrates

Night vision applications utilize the reflected nightglow radiation in the short-wavelength infrared (SWIR) atmospheric window. Nevertheless, the low light intensity values require dark current densities on the order of nA/cm(2) for detection around room temperature. Currently, with new device architectures and developments in growth and surface passivation, very low dark current density values are achievable for 1.7 mu m cutoff InGaAs detectors near room temperature, and such detectors seem to be the leading choice for the nightglow detection applications. On the other hand, HgCdTe has not been thoroughly investigated for low-cost nightglow detection with 1.7 mu m cutoff, primarily due to its manufacture expenses for lattice-matched CdZnTe growth. In this study, we analyze the nightglow radiation detecting performance of the alternative substrate HgCdTe detectors near room temperature (T = 270 K) using computer simulations. It is assessed that alternative substrate HgCdTe cannot attain the required dark current density values due to Shockley-Read-Hall (SRH) recombination in the depletion region, if the heterojunction photodiode structure is adopted. To overcome the problem, depletion-engineered devices are designed where the depletion region is embedded within a larger bandgap HgCdTe, which suppresses the depletion region SRH similar to 1300 times. This reduces the dark current density to the desired order, for SRH lifetimes achievable with alternative substrate growth. Dark current densities as low as 0.26 nA/m(2) are shown to be possible for an SRH lifetime of tau = 3 mu s while maintaining the quantum efficiency similar to 85%. With this approach benefiting from alternative substrates and depletion engineering, HgCdTe can achieve InGaAs nightglow imaging performances near room temperature, and can benefit from less costly manufacture and broader application capability for nightglow radiation detection. (C) 2019 Optical Society of America