1,665 research outputs found
TKGQA dataset: using question answering to guide and validate the evolution of temporal knowledge graph
Temporal knowledge graphs can be used to represent the current state of the world and, as daily events happen, the need to update the temporal knowledge graph, in order to stay consistent with the state of the world, becomes very important. However, there is currently no reliable method to accurately validate the update and evolution of knowledge graphs. There has been a recent development in text summarisation, whereby question answering is used to both guide and fact-check summarisation quality. The exact process can be applied to the temporal knowledge graph update process. To the best of our knowledge, there is currently no dataset that connects temporal knowledge graphs with documents with question–answer pairs. In this paper, we proposed the TKGQA dataset, consisting of over 5000 financial news documents related to M&A. Each document has extracted facts, question–answer pairs, and before and after temporal knowledge graphs, to highlight the state of temporal knowledge and any changes caused by the facts extracted from the document. As we parse through each document, we use question–answering to check and guide the update process of the temporal knowledge graph
Real-time processing of social media with SENTINEL: a syndromic surveillance system incorporating deep learning for health classification
Interest in real-time syndromic surveillance based on social media data has greatly increased in recent years. The ability to detect disease outbreaks earlier than traditional methods would be highly useful for public health officials. This paper describes a software system which is built upon recent developments in machine learning and data processing to achieve this goal. The system is built from reusable modules integrated into data processing pipelines that are easily deployable and configurable. It applies deep learning to the problem of classifying health-related tweets and is able to do so with high accuracy. It has the capability to detect illness outbreaks from Twitter data and then to build up and display information about these outbreaks, including relevant news articles, to provide situational awareness. It also provides nowcasting functionality of current disease levels from previous clinical data combined with Twitter data. The preliminary results are promising, with the system being able to detect outbreaks of influenza-like illness symptoms which could then be confirmed by existing official sources. The Nowcasting module shows that using social media data can improve prediction for multiple diseases over simply using traditional data sources
Successful synthesis of a glial-specific blood-brain barrier shuttle peptide following a fragment condensation approach on a solid-phase resin
Successful manual synthesis of the TD2.2 peptide acting as a blood-brain barrier shuttle was achieved. TD2.2 was successfully synthesised by sequential condensation of four protected peptide fragments on solid-phase settings, after several unsuccessful attempts using the stepwise approach. These fragments were chosen to minimize the number of demanding amino acids (in terms of coupling, Fmoc removal) in each fragment that are expected to hamper the overall synthetic process. Thus, the hydrophobic amino acids as well as Fmoc-Arg (Pbf)-OH were strategically spread over multiple fragments rather than having them congested in one fragment. This study shows how a peptide that shows big challenges in the synthesis using the common stepwise elongation methodology can be synthesised with an acceptable purity. It also emphasises that choosing the right fragment with certain amino acid constituents is key for a successful synthesis. It is worth highlighting that lower amounts of reagents were required to synthesise the final peptide with an identical purity to that obtained by the automatic synthesiser
Flexible Commissioning: A prevention and access focused approach in Yorkshire and the Humber
No abstract available
Crossover from weak to strong coupling regime in dispersive circuit QED
We study the decoherence of a superconducting qubit due to the dispersive
coupling to a damped harmonic oscillator. We go beyond the weak
qubit-oscillator coupling, which we associate with a phase Purcell effect, and
enter into a strong coupling regime, with qualitatively different behavior of
the dephasing rate. We identify and give a physicaly intuitive discussion of
both decoherence mechanisms. Our results can be applied, with small
adaptations, to a large variety of other physical systems, e. g. trapped ions
and cavity QED, boosting theoretical and experimental decoherence studies.Comment: Published versio
Open Spin Chains in Super Yang-Mills at Higher Loops: Some Potential Problems with Integrability
The super Yang-Mills duals of open strings attached to maximal giant
gravitons are studied in perturbation theory. It is shown that non-BPS baryonic
excitations of the gauge theory can be studied within the paradigm of open
quantum spin chains even beyond the leading order in perturbation theory. The
open spin chain describing the two loop mixing of non-BPS giant gravitons
charged under an su(2) of the so(6) R symmetry group is explicitly constructed.
It is also shown that although the corresponding open spin chain is integrable
at the one loop order, there is a potential breakdown of integrability at two
and higher loops. The study of integrability is performed using coordinate
Bethe ansatz techniques.Comment: 28 pages. References added in revised versio
Lower Serum Testosterone Associated with Elevated Polychlorinated Biphenyl Concentrations in Native American Men
Background: Polychlorinated biphenyls (PCBs) and chlorinated pesticides are endocrine disruptors, altering both thyroid and estrogen hormonal systems. Less is known of action on androgenic systems. Objective: We studied the relationship between serum concentrations of testosterone in relation to levels of PCBs and three chlorinated pesticides in an adult Native American (Mohawk) population. Methods: We collected fasting serum samples from 703 adult Mohawks (257 men and 436 women) and analyzed samples for 101 PCB congeners, hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (DDE), and mirex, as well as testosterone, cholesterol, and triglycerides. The associations between testosterone and tertiles of serum organochlorine levels (both wet weight and lipid adjusted) were assessed using a logistic regression model while controlling for age, body mass index (BMI), and other analytes, with the lowest tertile being considered the referent. Males and females were considered separately. Results: Testosterone concentrations in males were inversely correlated with total PCB concentration, whether using wet-weight or lipid-adjusted values. The odds ratio (OR) of having a testosterone concentration above the median was 0.17 [95% confidence interval (CI), 0.05–0.69] for total wet-weight PCBs (highest vs. lowest tertile) after adjustment for age, BMI, total serum lipids, and three pesticides. The OR for lipid-adjusted total PCB concentration was 0.23 (95% CI, 0.06–0.78) after adjustment for other analytes. Testosterone levels were significantly and inversely related to concentrations of PCBs 74, 99, 153, and 206, but not PCBs 52, 105, 118, 138, 170, 180, 201, or 203. Testosterone concentrations in females are much lower than in males, and not significantly related to serum PCBs. HCB, DDE, and mirex were not associated with testosterone concentration in either men or women. Conclusions: Elevation in serum PCB levels is associated with a lower concentration of serum testosterone in Native American men
A Classification of random Dirac fermions
We present a detailed classification of random Dirac hamiltonians in two
spatial dimensions based on the implementation of discrete symmetries. Our
classification is slightly finer than that of random matrices, and contains
thirteen classes. We also extend this classification to non-hermitian
hamiltonians with and without Dirac structure.Comment: 15 pages, version2: typos in the table of classes are correcte
EuroGammaS gamma characterisation system for ELI-NP-GBS: The nuclear resonance scattering technique
A Gamma Beam Characterisation System has been designed by the EuroGammaS association for thecommissioning and development of the Extreme Light Infrastructure-Nuclear Physics Gamma Beam System(ELI-NP-GBS) to be installed in Magurele, Romania. The characterisation system consists of four elements: aCompton spectrometer, a sampling calorimeter, a nuclear resonant scattering spectrometer (NRSS) and a beamprofile imager. In this paper, the nuclear resonant scattering spectrometer system, designed to perform anabsolute energy calibration for the gamma beam, will be describe
- …