La adquisición de competencias en los alumnos del Grado en Relaciones Laborales y Recursos Humanos de la Universidad de Huelva

La declaración de Bolonia plantea nuevos objetivos académicos para adecuarse a las necesidades que exige el mercado de trabajo, y ello implica la transformación de los sistemas educativos para adaptarse a los requerimientos de la nueva coyuntura de los sistemas productivos. Bolonia crea el Espacio Europeo de Educación Superior (EEES) y una de sus premisas se basa en la adquisición de competencias por parte del estudiante. En esta investigación se pretende conocer la opinión de un grupo de alumnos de segundo curso del grado en Relaciones Laborales y Recursos Humanos de la Universidad de Huelva sobre la importancia y el grado de adquisición de varias competencias seleccionadas. Para ello se les facilitó un doble cuestionario en escala tipo Likert. El primero con la valoración de dichas competencias y el segundo con el grado de adquisición que creen poseer de cada una de ellas. Los resultados evidencian desajustes entre importancia y adquisición, así como diferencias estadísticamente significativas en función de las situaciones personales de los alumnos.The Bologna declaration has created new academic goals in order to suit the labor market demands, and this implies the transformation of education systems to adjust to the new situation in the production systems. Bologna sets up the European Higher Education Area (EHEA), and the acquisition of skills by the students as one of its fundamental principles. This reseach aims to assess the views of a group of second – year students (degree in Labour Relations and Human Resources management – UNIVERSITY OF HUELVA) on the importance and the extent to which they think to have acquired severat selected competencies. They were provided with a double Liker type scale questionnaire. The first one had the assessment of thease skills and the second the extent to which they thought to have acquired in everyone of them. The findings show disparities between their importance and acquisition, as well as statisally significant differences in correlation to the students personal situations

Contribution of microscopy for understanding the mechanism of action against trypanosomatids

Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs. Thus, it has been observed that sesquiterpene lactones induce diverse ultrastructural alterations in both T. cruzi and Leishmania spp., such as cytoplasmic vacuolization, appearance of multilamellar structures, condensation of nuclear DNA, and, in some cases, an important accumulation of lipid vacuoles. This accumulation could be related to apoptotic events. Some of the sesquiterpene lactones (e.g., psilostachyin) have also been demonstrated to cause an intense mitochondrial swelling accompanied by a visible kinetoplast deformation as well as the appearance of multivesicular bodies. This mitochondrial swelling could be related to the generation of oxidative stress and associated to alterations in the ergosterol metabolism. The appearance of multilamellar structures and multiple kinetoplasts and flagella induced by the sesquiterpene lactone psilostachyin C indicates that this compound would act at the parasite cell cycle level, in an intermediate stage between kinetoplast segregation and nuclear division. In turn, the diterpene lactone icetexane has proved to induce the external membrane budding on T. cruzi together with an apparent disorganization of the pericellar cytoskeleton. Thus, ultrastructural TEM studies allow elucidating the possible mechanisms and the subsequent identification of molecular targets for the action of natural compounds on trypanosomatids.Fil: Lozano, Esteban Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Spina Zapata, Renata María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Barrera, Patricia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Sosa Escudero, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentin

Plant metabolites active against Trypanosoma cruzi

Parasitic diseases are widespread in less developed countries, and are a major cause of suffering and inability of the affected populations to improve their own living conditions. Among these diseases, American trypanosomiasis (Chagas' disease), due to the kinetoplastid protozoon Trypanosoma cruzi, is particularly relevant to Latin America. The natural products literature mentions a wide variety of isolated substances showing activity against this parasite. Although some of these compounds appear to be promising leads, their potential is presently limited by the need of high concentrations, unfavorable pharmacokinetics, and/or by their low solubility in blood. Their mechanisms of action are unknown in most cases, although some trends appear to be emerging. This review presents and discusses the data available until mid-1995

SINTESIS DE 2.ARIL.1,3.DINITROPROPANOS, INTERMEDIARIOS PARA LA OBTENCION DE NUEVOS ANTIDEPRESIVOS

Se describe la síntesis de una serie de 2-aril-l,3-dinitropropanos por condensación de benzaldehidos con nitrometano. Estos compuestos tienen utilidad potencial como precursores de 2-aril-1,3-dinitropropanos, los que a su vez ocupan un lugar central en la vía que conduce a las 2-amino-5-aril-1,4,5,6-tetrahidropirimidinas antidepresi vas

A novel route to 5,7-dimethoxy-6-hydroxyflavone

A novel route to 5,7-dimethoxy-6-hydroxyflavone is described, involving the cyclization of an intermediate phosphorane as the key step

Structure–activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2

Human lipoxygenase (hLO) isozymes have been implicated in a number of disease states and have attracted much attention with respect to their inhibition. One class of inhibitors, the flavonoids, have been shown to be potent lipoxygenase inhibitors but their study has been restricted to those compounds found in nature, which have limited structural variability. We have therefore carried out a comprehensive study to determine the structural requirements for flavonoid potency and selectivity against platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. We conclude from this study that catechols are essential for high potency, that isoflavones and isoflavonones tend to select against 12-hLO, that isoflavons tend to select against 15-hLO-1, but few flavonoids target 15-hLO-2

MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the b-position

Abstract—Twenty-nine arylisopropylamines, substituted at the b-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives (‘cathinones’) were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-B inhibiting activity, which was absent in the hydroxy, methoxy, and b-unsubstituted analogues. These results suggest that selective affinity for the two MAO isoforms in this family of compounds is modulated not only by the aryl substitution pattern but also by the side-chain substituents on the arylalkylamine scaffold.This work was supported by FONDECYT grant No. 1000776 and MECESUP-USA0007 project