Caracterización del gen de la dopamina B-hidroxilasa en población mestiza colombiana

La dopamina B-hidroxilasa cataliza la conversión de dopamina en norepinefrina y es blanco promisorio de intervenciones farmacológicas. Polimorfismos del gen DBH son responsables de las diferencias individuales en el tono dopaminérgico y adrenérgico de los sistemas nervioso central y autónomo. Ya que las mutaciones defectuosas de la enzima y sus frecuencias varían entre las etnias, se justifican los estudios conducentes a la caracterización genotípica y fenotípica de la enzima en mestizos colombianos

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β in DM mice. IL-1β causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity. IL-1β-induced spontaneous contractile events are associated with CaMKII oxidation and phosphorylation. We further show that DM-induced arrhythmias can be successfully treated by inhibiting the IL-1β axis with either IL-1 receptor antagonist or by inhibiting the NLRP3 inflammasome. Our results establish IL-1β as an inflammatory connection between metabolic dysfunction and arrhythmias in DM.Facultad de Ciencias MédicasCentro de Investigaciones Cardiovasculare

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β in DM mice. IL-1β causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity. IL-1β-induced spontaneous contractile events are associated with CaMKII oxidation and phosphorylation. We further show that DM-induced arrhythmias can be successfully treated by inhibiting the IL-1β axis with either IL-1 receptor antagonist or by inhibiting the NLRP3 inflammasome. Our results establish IL-1β as an inflammatory connection between metabolic dysfunction and arrhythmias in DM.Facultad de Ciencias MédicasCentro de Investigaciones Cardiovasculare

Miradas desde la historia social y la historia intelectual: América Latina en sus culturas: de los procesos independistas a la globalización

Fil: Benito Moya, Silvano G. A. Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina

The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics

Editorial: bioprocess optimization: the potential of agro-food by-products

info:eu-repo/semantics/publishedVersio

Dynamics and Stability on a Family of Optimal Fourth-Order Iterative Methods

In this manuscript, we propose a parametric family of iterative methods of fourth-order convergence, and the stability of the class is studied through the use of tools of complex dynamics. We obtain the fixed and critical points of the rational operator associated with the family. A stability analysis of the fixed points allows us to find sets of values of the parameter for which the behavior of the corresponding method is stable or unstable; therefore, we can select the regions of the parameter in which the methods behave more efficiently when they are applied for solving nonlinear equations or the regions in which the schemes have chaotic behavior

Dynamics and Stability on a Family of Optimal Fourth-Order Iterative Methods

[EN] In this manuscript, we propose a parametric family of iterative methods of fourth-order convergence, and the stability of the class is studied through the use of tools of complex dynamics. We obtain the fixed and critical points of the rational operator associated with the family. A stability analysis of the fixed points allows us to find sets of values of the parameter for which the behavior of the corresponding method is stable or unstable; therefore, we can select the regions of the parameter in which the methods behave more efficiently when they are applied for solving nonlinear equations or the regions in which the schemes have chaotic behavior.This research was funded by PGC2018-095896-B-C22 and by MCIN/AEI/10.13039/5011000113033 as part of "ERDF: A way to making Europe".Cordero Barbero, A.; Leonardo Sepúlveda, MA.; Torregrosa Sánchez, JR. (2022). Dynamics and Stability on a Family of Optimal Fourth-Order Iterative Methods. Algorithms. 15(10):1-13. https://doi.org/10.3390/a15100387113151