Syntheses and Characterizations of Some New N-alkyl, Isoxazole and Dioxazole Derivatives of 5-Chloroisatin

N-alkyl and cycloadducts derivatives of 5-Chloroisatin were synthesized in good to excellent yields. The method evidences a selective N-alkylation when using 1,2-bis (2-chloroethoxy) ethane as efficient spacer at room temperature on the 5-Chloroisatin moiety. A general method for the 1,3-dipolar cycloaddition of 4-Chlorobenzaldoxime to alkynes provides a useful alternative route to get newisoxazole et dioxazole derivatives

Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1,3-Dipolar Cycloaddition Reactions

A facile and simple protocol for the ‘Click\u27 cycloaddition of organic azides with N-propargylchloroisatine catalyzed by CuI, produces in good yields novel of 1,4-disubstituted 1,2,3-triazoles were obtained. Compared to the uncatalyzed cycloaddition, the yields are significantly improved in the presence of CuI as catalyst, without alteration of the selectivity. The regio- and stereochemistry of the cycloadducts has been corroborated by 1H, 13C NMR spectroscopy

Study of the inhibition of corrosion of mild steel in a 1M HCl solution by a new quaternary ammonium surfactant

The anticorrosive effect of surfactant, 12-(2,3-dioxoindolin-1-yl)-N,N,N-trimethyldodecanammonium bromide 3 on the corrosion of mild steel in 1M hydrochloric acid was assessed by gravimetric and electrochemical techniques (potentiodynamic polarization and electrochemical impedance spectroscopy). The results have shown that our synthesized surfactant is an excellent corrosion inhibitor for mild steel in 1 M HCl. Inhibitory efficacy of up to 95.9% was exhibited by surfactant 3 at a concentration of 1 mM after 6 h immersion at 298K. Based on the polarization curves, it is clear that the surfactant 3 can be considered as a mixed inhibitor with a predominantly anodic character. The inhibitory effectiveness increases with increasing concentration but decreases with increasing temperature. It was found that the adsorption of the inhibitor on the surface of the mild steel in 1M HCl followed the Langmuir adsorption isotherm. In this context, the main kinetic and thermodynamic parameters were determined and discussed

Optimization of growth and extracellular glucoamylase production by Candida famata isolate

Candida famata was isolated from traditional Moroccan sourdough. It exhibited high glucoamylase and biomass production. Starch induces high glucoamylase production C. famata with maximum glucoamylase activity at 5 g/L. Glucose stimulates good production in biomass but strongly inhibitsglucoamylase production. Among the sources of nitrogen tested, yeast extract and the (NH4)2HPO4 gave maximum glucoamylase and biomass after 72 h of incubation in liquid medium at 30°C, pH 5 and 105 rpm

Synthesis Characterization And Photopolymerization Of Novel Phosphonated Materials

New phosphonated cross-linked materials were synthesized from telomers obtained by reaction between 10-undecenol and dialkyl hydrogenphosphonates. Telomers were then converted to materials resins by methacrylation reactions. Finally, photopolymerization of the different materials synthesized was achieved and influence of the nature of the phosphonate group (diester, monoacid and diacid) was also evaluated.New phosphonated cross-linked materials were synthesized from telomers obtained by reaction between 10-undecenol and dialkyl hydrogenphosphonates. Telomers were then converted to materials resins by methacrylation reactions. Finally, photopolymerization of the different materials synthesized was achieved and influence of the nature of the phosphonate group (diester, monoacid and diacid) was also evaluated

Inhibitive effect of some phosphonate derivatives on the corrosion of carbon steel in 2 M H3PO4

Corrosion inhibition performance of some phosphonate derivatives, namely, dodecylphosphonic acid (YM1),  sodium methyl dodecylphosphonate (YM2) and methyl hydrogen dodecylphosphonate (YM3)  on carbon steel in 2 M H3PO4 solution was investigated by means of weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. These compounds inhibit the corrosion rate even at very low concentrations and the order of increasing inhibition efficiency was correlated with the modification of the molecular structure of the inhibitors. Polarization curves indicated that these compounds acted primarily as mixed-type inhibitors. The adsorption of these compounds on carbon steel surface has been found to obey Langmuir’s adsorption isotherm. E% values obtained from weight-loss and electrochemical methods were in good agreement. size:12.0pt;line-height:200%;font-family:"Times New Roman","serif"; color:black'>.

Reliability of the Arabic Smartphone Addiction Scale and Smartphone Addiction Scale-Short Version in Two Different Moroccan Samples

The extensive accessibility to smartphones in the last decade raises the concerns of addictive behavior patterns toward these technologies worldwide and in developing countries, and Arabic ones in particular. In an area of stigmatized behavior such as Internet and smartphone addiction, the hypothesis extends to whether there is a reliable instrument that can assess smartphone addiction. To our knowledge, no scale in Arabic language is available to assess maladaptive behavior associated with smartphone use. This study aims to assess the factorial validity and internal reliability of the Arabic Smartphone Addiction Scale (SAS) and Smartphone Addiction Scale-Short Version (SAS-SV) in a Moroccan surveyed population. Participants (N = 440 and N = 310) completed an online survey, including SAS, SAS-SV, and questions about sociodemographic status. Factor analysis results showed six factors with factor loading ranging from 0.25 to 0.99 for SAS. Reliability, based on Cronbach's alpha, was excellent (α = 0.94) for this instrument. The SAS-SV showed one factor (unidimensional construct), and internal reliability was in the good range with an alpha coefficient of (α = 0.87). The prevalence of excessive users was 55.8 percent with highest symptom prevalence reported for tolerance and preoccupation. This study proved factor validity of the Arabic SAS and SAS-SV instruments and confirmed their internal reliability. © 2018, Mary Ann Liebert, Inc

Linear IgA bullous dermatosis in a child successfully responding to oral antibiotics

Linear IgA bullous dermatosis (LABD) is a rare, chronic, autoimmune bullous dermatosis affecting young children and adults. The exact pathogenesis of this disease is still unknown, although both humoral and cellular immune response are involved. Clinically, it may show heterogeneous skin manifestations. However, it is characterized histologically by linear immunoglobulin A (IgA) deposits over the basal membrane, causing subepidermal blisters. Studies on LABD are relatively sparse and most of the publications are small series or single case reports. Several treatments are reported in literature, however, they should be used with care due to the risk of side effects. We report a case of linear IgA dermatosis with generalized lesions in a 7 year old child, with good outcome under dermocorticoids and antibiotics