Is the LAN effect in morphosyntactic processing an ERP artifact?

Available online 4 February 2019.The left anterior negativity (LAN) is an ERP component that has been often associated with morphosyntactic processing, but recent reports have questioned whether the LAN effect, in fact, exists. The present project examined whether the LAN effect, observed in the grand average response to local agreement violations, is the result of the overlap between two different ERP effects (N400, P600) at the level of subjects (n = 80), items (n = 120), or trials (n = 6160). By-subject, by-item, and by-trial analyses of the ERP effect between 300 and 500 ms showed a LAN for 55% of the participants, 46% of the items, and 49% of the trials. Many examples of the biphasic LAN-P600 response were observed. Mixed-linear models showed that the LAN effect size was not reduced after accounting for subject variability. The present results suggest that there are cases where the grand average LAN effect represents the brain responses of individual participants, items, and trials.This work was supported by the Spanish Ministry [PSI 2014-54500- P; IJCI-2016-27702; PSI2017-82941-P]; the Basque Government [PI_2015_1_25]; and the Severo Ochoa [SEV-2015-0490]

Reading-Related Brain Changes in Audiovisual Processing: Cross-Sectional and Longitudinal MEG Evidence

Published July 7, 2021The ability to establish associations between visual objects and speech sounds is essential for human reading. Understanding the neural adjustments required for acquisition of these arbitrary audiovisual associations can shed light on fundamental reading mechanisms and help reveal how literacy builds on pre-existing brain circuits. To address these questions, the present longitudinal and cross-sectional MEG studies characterize the temporal and spatial neural correlates of audiovisual syllable congruency in children (age range, 4–9 years; 22 males and 20 females) learning to read. Both studies showed that during the first years of reading instruction children gradually set up audiovisual correspondences between letters and speech sounds, which can be detected within the first 400 ms of a bimodal presentation and recruit the superior portions of the left temporal cortex. These findings suggest that children progressively change the way they treat audiovisual syllables as a function of their reading experience. This reading-specific brain plasticity implies (partial) recruitment of pre-existing brain circuits for audiovisual analysis.This project received funding from the European Union’s Horizon 2020 research and innovation program under Marie Sklodowska-Curie Grant Agreement No. 837228 (H2020-MSCA-IF-2018-837228-ENGRAVING). The project was also funded by the Spanish Ministry of Economy, Industry and Competitiveness (Grant PSI2017- 82941-P), the Basque Government through the BERC 2018-2021 Program, and the Agencia Estatal de Investigación through BCBL (Basque Center on Cognition, Brain and Language) Severo Ochoa excellence accreditation SEV-2015-0490

When A Nonnative Accent Lets You Spot All the Errors: Examining the Syntactic Interlanguage Benefit

Published August 01 2022In our continuously globalizing world, cross-cultural and cross-linguistic communications are far from exceptional. A wealth of research has indicated that the processing of nonnative-accented speech can be challenging for native listeners, both at the level of phonology. However, few online studies have examined the underpinnings of accented speech recognition from the perspective of the nonnative listener, even though behavioral studies indicate that accented input may be easier to process for such individuals (i.e., the interlanguage speech intelligibility benefit. The current EEG study first examined the phonological and syntactic analysis of nonnative-accented speech among nonnative listeners. As such, 30 English learners of Spanish listened to syntactically correct and incorrect Spanish sentences produced in native and nonnative-accented Spanish. The violation in the incorrect sentences was caused by errors that are typical (i.e., gender errors; *la color) or atypical (i.e., number errors; *los color) for English learners of Spanish. Results indicated that nonnative listeners elicit a phonological mismatch negativity (PMN) when attending to speech produced by a native Spanish speaker. Furthermore, the nonnative listeners showed a P600 for all grammatical violations, indicating that they repair all errors regardless of their typicality or the accent in which they are produced. Follow-up analyses compared our novel data to the data of native listeners from the methodologically identical precursor study. These analyses showed that native and nonnative listeners exhibit directionally opposite PMN effects; whereas natives exhibited a larger PMN for English-accented Spanish, nonnatives displayed a larger PMN in response to native Spanish utterances (a classic interlanguage speech intelligibility benefit). An additional difference was observed at the syntactic level: Whereas natives repaired only atypical number errors when they were English-accented, nonnative participants exhibited a P600 in response to all English-accented syntactic errors, regardless of their typicality (a syntactic interlanguage speech intelligibility benefit). Altogether, these results suggest that accented speech is not inherently difficult to process; in fact, nonnatives may benefit from the presence of a nonnative accent. Thus, our data provide some of the first electrophysiological evidence supporting the existence of the classic interlanguage speech intelligibility benefit and its novel syntactic counterpartThis international collaboration was made possible by a Globalink Research Abroad Award (https://dx.doi.org/10 .13039/501100004489) conferred to the first author. The research was supported by the Spanish Ministry of Economy and Competitiveness (CEX2020-001010-S to the BCBL; PID2020-113926GB-I00 to C. D. M.), the Basque government (PIBA18_29 to C. D. M.). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (https://dx.doi.org/10.13039 /100010663), grant number: 819093 to C. D. M., the European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska-Curie (https://dx.doi .org/10.13039/100010663), grant number: 837228 (H2020- MSCA-IF-2018-837228) and the Rita Levi Montalcini fellowship to S. C

When is irony influenced by communicative constraints? ERP evidence supporting interactive models

First published: 07 July 2019Distinct theoretical proposals have described how communicative constraints (contextual biases, speaker identity) impact verbal irony processing. Modular models assume that social and contextual factors have an effect at a late stage of processing. Interactive models claim that contextual biases are considered early on. The constraint‐ satisfaction model further assumes that speaker's and context's characteristics can compete at early stages of analysis. The present ERP study teased apart these models by testing the impact of context and speaker features (i.e., speaker accent) on irony analysis. Spanish native speakers were presented with Spanish utterances that were ironic or literal. Each sentence was preceded by a negative or a positive context. Each story was uttered in a native or a foreign accent. Results showed that contextual biases and speaker accent interacted as early as 150 ms during irony processing. Greater N400‐like effects were reported for ironic than literal sentences only with positive contexts and native accent, possibly suggesting semantic difficulties when non‐prototypical irony was produced by natives. A P600 effect of irony was also reported indicating inferential processing costs. The results support the constraintsatisfaction model and suggest that multiple sources of information are weighted and can interact from the earliest stages of irony analysis.Spanish State Research Agency (Severo Ochoa excellence accreditation), Grant/ Award Number: SEV‐2015‐0490; the Basque Government, Grant/Award Number: BERC 2018–2021, PI_2015_1_25; Spanish Ministry of Economy and Competitiveness, Grant/Award Number: PSI2014‐54500, PSI2017‐82941‐P, IJCI‐2016‐27702; Grant/Award Number: H2020‐MSCA‐IF‐2018‐837228. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 837228

Anatomy and physiology of word-selective visual cortex: from visual features to lexical processing

Over the past 2 decades, researchers have tried to uncover how the human brain can extract linguistic information from a sequence of visual symbols. The description of how the brain's visual system processes words and enables reading has improved with the progressive refinement of experimental methodologies and neuroimaging techniques. This review provides a brief overview of this research journey. We start by describing classical models of object recognition in non-human primates, which represent the foundation for many of the early models of visual word recognition in humans. We then review functional neuroimaging studies investigating the word-selective regions in visual cortex. This research led to the differentiation of highly specialized areas, which are involved in the analysis of different aspects of written language. We then consider the corresponding anatomical measurements and provide a description of the main white matter pathways carrying neural signals crucial to word recognition. Finally, in an attempt to integrate structural, functional, and electrophysiological findings, we propose a view of visual word recognition, accounting for spatial and temporal facets of word-selective neural processes. This multi-modal perspective on the neural circuitry of literacy highlights the relevance of a posterior-anterior differentiation in ventral occipitotemporal cortex for visual processing of written language and lexical features. It also highlights unanswered questions that can guide us towards future research directions. Bridging measures of brain structure and function will help us reach a more precise understanding of the transformation from vision to language

Anatomy and physiology of word‑selective visual cortex: from visual features to lexical processing

Published: 12 October 2021Over the past 2 decades, researchers have tried to uncover how the human brain can extract linguistic information from a sequence of visual symbols. The description of how the brain’s visual system processes words and enables reading has improved with the progressive refinement of experimental methodologies and neuroimaging techniques. This review provides a brief overview of this research journey. We start by describing classical models of object recognition in non-human primates, which represent the foundation for many of the early models of visual word recognition in humans. We then review functional neuroimaging studies investigating the word-selective regions in visual cortex. This research led to the differentiation of highly specialized areas, which are involved in the analysis of different aspects of written language. We then consider the corresponding anatomical measurements and provide a description of the main white matter pathways carrying neural signals crucial to word recognition. Finally, in an attempt to integrate structural, functional, and electrophysiological findings, we propose a view of visual word recognition, accounting for spatial and temporal facets of word-selective neural processes. This multi-modal perspective on the neural circuitry of literacy highlights the relevance of a posterior–anterior differentiation in ventral occipitotemporal cortex for visual processing of written language and lexical features. It also highlights unanswered questions that can guide us towards future research directions. Bridging measures of brain structure and function will help us reach a more precise understanding of the transformation from vision to language.This work was supported by European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 837228 and Rita Levi Montalcini fellowship to SC, NICHD R01-HD095861 and Jacobs Foundation Research Fellowship to JDY, Stanford Maternal and Child Health Research Institute award to IK, and the Zuckerman-CHE STEM Leadership Program to MY

Development of the visual white matter pathways mediates development of electrophysiological responses in visual cortex

First published: 06 September 2021The latency of neural responses in the visual cortex changes systematically across the lifespan. Here, we test the hypothesis that development of visual white matter pathways mediates maturational changes in the latency of visual signals. Thirty-eight children participated in a cross-sectional study including diffusion magnetic resonance imaging (MRI) and magnetoencephalography (MEG) sessions. During the MEG acquisition, participants performed a lexical decision and a fixation task on words presented at varying levels of contrast and noise. For all stimuli and tasks, early evoked fields were observed around 100 ms after stimulus onset (M100), with slower and lower amplitude responses for low as compared to high contrast stimuli. The optic radiations and optic tracts were identified in each individual's brain based on diffusion MRI tractography. The diffusion properties of the optic radiations predicted M100 responses, especially for high contrast stimuli. Higher optic radiation fractional anisotropy (FA) values were associated with faster and larger M100 responses. Over this developmental window, the M100 responses to high contrast stimuli became faster with age and the optic radiation FA mediated this effect. These findings suggest that the maturation of the optic radiations over childhood accounts for individual variations observed in the developmental trajectory of visual cortex responses.H2020 Marie Skłodowska-Curie Actions, Grant/Award Number: 837228; Italian Ministry of University and Research (MIUR): Programma Rita Levi Montalcini; Jacobs Foundation Research Fellowship, Grant/Award Number: RF1MH121868-01; National Institute of Child Health and Human Development, Grant/Award Numbers: R01HD09586101, R21HD092771; National Research Foundation of Korea, Grant/Award Number: NRF-2019R1C1C1009383; NSF/ BSF, Grant/Award Number: BCS #155133

Representation and processing of multi-word expressions in the brain

Language comprehension is sensitive to the predictability of the upcoming information. Prediction allows for smooth, expedient and successful communication. While general discourse-based constraints have been investigated in detail, more specific phrase-level prediction has received little attention. We address this gap by exploring the ERPs elicited during the comprehension of English binomials – familiar and predictable multi-word expressions. In Experiment 1a, participants read binomial expressions (knife and fork), infrequent strongly associated phrases (spoon and fork), and semantic violations (theme and fork). In Experiment 1b, participants read the same stimuli without “and”. Experiment 1a revealed that binomials elicited larger P300s and smaller N400s compared to the other conditions, reflecting the activation of a ‘template’ that matches the upcoming information (P300) and pointing to easier semantic integration (N400). In contrast, no differences were observed between binomials and associates in Experiment 1b. We conclude that distinct mechanisms underlie the processing of predicable and novel sequences

Optic radiations representing different eccentricities age differently

The neural pathways that carry information from the foveal, macular, and peripheral visual fields have distinct biological properties. The optic radiations (OR) carry foveal and peripheral information from the thalamus to the primary visual cortex (V1) through adjacent but separate pathways in the white matter. Here, we perform white matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data from subjects with healthy vision in the U.K. Biobank dataset (UKBB; N = 5382; age 45-81). We use pyAFQ to characterize white matter tissue properties in parts of the OR that transmit information about the foveal, macular, and peripheral visual fields, and to characterize the changes in these tissue properties with age. We find that (1) independent of age there is higher fractional anisotropy, lower mean diffusivity, and higher mean kurtosis in the foveal and macular OR than in peripheral OR, consistent with denser, more organized nerve fiber populations in foveal/parafoveal pathways, and (2) age is associated with increased diffusivity and decreased anisotropy and kurtosis, consistent with decreased density and tissue organization with aging. However, anisotropy in foveal OR decreases faster with age than in peripheral OR, while diffusivity increases faster in peripheral OR, suggesting foveal/peri-foveal OR and peripheral OR differ in how they age

Trauma-Related Distress During the COVID-19 Pandemic In 59 Countries

First published online March 11, 2022The COVID-19 pandemic has upended life like few other events in modern history, with differential impacts on varying population groups. This study examined trauma-related distress among 6,882 adults ages 18 to 94 years old in 59 countries during April to May 2020. More than two-thirds of participants reported clinically significant trauma-related distress. Increased distress was associated with unemployment; identifying as transgender, nonbinary, or a cisgender woman; being from a higher income country; current symptoms and positive diagnosis of COVID-19; death of a loved one; restrictive government-imposed isolation; financial difficulties; and food insecurity. Other factors associated with distress included working with potentially infected individuals, care needs at home, a difficult transition to working from home, conflict in the home, separation from loved ones, and event restrictions. Latin American and Caribbean participants reported more trauma-related distress than participants from Europe and Central Asia. Findings inform treatment efforts and highlight the need to address trauma-related distress to avoid long-term mental health consequences.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the European Commission (H2020-MSCA-IF-2018-837228-ENGRAVING). Daniela Ramos-Usuga was supported by a predoctoral fellowship from the Basque Government (PRE_2019_1_0164)