3 research outputs found
Formation of Well-Defined, Functional Nanotubes via Osmotically Induced Shape Transformation of Biodegradable Polymersomes
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Formation of well-defined, functional nanotubes via osmotically induced shape transformation of biodegradable polymersomes
Polymersomes are robust, versatile nanostructures that can be tailored by varying the chemical structure of copolymeric building blocks, giving control over their size, shape, surface chemistry, and membrane permeability. In particular, the generation of nonspherical nanostructures has attracted much attention recently, as it has been demonstrated that shape affects function in a biomedical context. Until now, nonspherical polymersomes have only been constructed from nondegradable building blocks, hampering a detailed investigation of shape effects in nanomedicine for this category of nanostructures. Herein, we demonstrate the spontaneous elongation of spherical polymersomes comprising the biodegradable copolymer poly(ethylene glycol)-b-poly(d,l-lactide) into well-defined nanotubes. The size of these tubes is osmotically controlled using dialysis, which makes them very easy to prepare. To confirm their utility for biomedical applications, we have demonstrated that, alongside drug loading, functional proteins can be tethered to the surface utilizing bio-orthogonal “click” chemistry. In this way the present findings establish a novel platform for the creation of biocompatible, high-aspect ratio nanoparticles for biomedical research
Formation of Well-Defined, Functional Nanotubes via Osmotically Induced Shape Transformation of Biodegradable Polymersomes
Polymersomes are
robust, versatile nanostructures that can be tailored
by varying the chemical structure of copolymeric building blocks,
giving control over their size, shape, surface chemistry, and membrane
permeability. In particular, the generation of nonspherical nanostructures
has attracted much attention recently, as it has been demonstrated
that shape affects function in a biomedical context. Until now, nonspherical
polymersomes have only been constructed from nondegradable building
blocks, hampering a detailed investigation of shape effects in nanomedicine
for this category of nanostructures. Herein, we demonstrate the spontaneous
elongation of spherical polymersomes comprising the biodegradable
copolymer poly(ethylene glycol)-<i>b</i>-poly(d,l-lactide) into well-defined nanotubes. The size of these
tubes is osmotically controlled using dialysis, which makes them very
easy to prepare. To confirm their utility for biomedical applications,
we have demonstrated that, alongside drug loading, functional proteins
can be tethered to the surface utilizing bio-orthogonal “click”
chemistry. In this way the present findings establish a novel platform
for the creation of biocompatible, high-aspect ratio nanoparticles
for biomedical research