Temporal summation in a neuromimetic micropillar laser

Neuromimetic systems are systems mimicking the functionalities orarchitecture of biological neurons and may present an alternativepath for efficient computing and information processing. We demonstratehere experimentally temporal summation in a neuromimetic micropillarlaser with integrated saturable absorber. Temporal summation is theproperty of neurons to integrate delayed input stimuli and to respondby an all-or-none kind of response if the inputs arrive in a sufficientlysmall time window. Our system alone may act as a fast optical coincidence detector and paves the way to fast photonic spike processing networks

Perilaku dan Loyalitas Konsumen Madu di Kota Bengkulu

Indonesia with a current population of nearly 240 million people, is the 4th largest population in the world need quite a lot of honey. The research objective was to analyze customer characteristics honey based group of consumers, identify the attributes of honey products that affect on purchase decisions, analyze consumer behavior and customer loyalty to honey, analyze the marketing mix right is based on the analysis of consumer behavior and consumer perception of the local honey product, and formulate strategies marketing of honey in the city of Bengkulu. Determining the location of the research conducted on honey outlets in the city of Bengkulu, the selection was conducted intentionally (purposive).The location of this study were at 8 stores/outlets of honey and herbs as well as a fairly large supermarket, honey outlets which was set as the study site. Data collection was done during the months of June-August 2015. The number of respondents in this study was 96. The data collected in this research were primary and secondary data that being collected to obtain the study aims to analysis of consumer behavior is processed using Importance Performance Analysis (IPA), and analysis of loyalty consumer using the Customer Satisfaction Index (CSI). The method results Importance Performance Analysisis based on Cartesian diagram shows that there is one attribute that is considered important and is the main priority in determining customer satisfaction. The attribute was the special price for every purchase at a time/day/month special like, Ramadhan, Eid and other interest consumen calculation. Based Satisfaction Index, the level of consumer satisfaction reached 71.30% honey. The calculation results show that in general consumers of honey was categorized satisfied (0.61 <CSI ? 0.80)

Strategi Pengembangan Koperasi Mahasiswa Universitas Negeri Papua

  Purpose of this study is to identify and analyze internal and external factors that influence the development Kopma Unipa and to develop and recommend alternative strategies that can be applied in the development of Kopma Unipa . The study was conducted at the Student Cooperative Unipa. Subjects in this study are the management of the Student Cooperative. While method analysis used to formulate a strategy is a descriptive analysis and SWOT analysis using the SWOT and SWOT Matrix Diagrams. Analysis identifying the internal and external environment Kopma Unipa show that the strength is Kopma Unipa have democratic oversight system, has legal entities, the student has the intellectual capital and high creativity, capital aid from the University, has a diverse unit activity, and the relative price equal to competitors. While Kopma weakness is less strategic location, students have time constraints, lack of understanding of cooperative, low management capabilities, weak participation of members, the promotion is not maximized, the lack of training or training, products sold are still limited choice and number, and space cooperatives are less extensive. Based on the SWOT analysis matrix formulation of strategies to develop Kopma Unipa is to increase the role and participation of students in Kopma, increasing the supply of primary goods into student, develop innovation in all aspects of the utilization of technological progress, expand market share, forming a pattern of good marketing, improving the ability of management, strategic build a separate building, build a corporation and coordination with the Government, Academic and cooperatives that exist in the region, improve service quality, and internal consolidation

Degradation Risk Assessment: Understanding the Impacts of Climate Change on Geoheritage

Several factors and processes, both natural and anthropogenic, can threaten the integrity of any geosite, leading to their degradation. For this reason, geoheritage degradation risks should be considered a fundamental step in any geoconservation strategy, all the more when the aim is to tackle the effects of climate change. The present work proposes a quantitative methodology for the degradation risk assessment of geosites by considering the extrinsic factors that can damage the geoheritage. The methodology has been tested on the Maltese Islands, where considerable previous research has been undertaken in order to highlight the international significance of the Maltese landscapes. Three criteria to assess the degradation risk are proposed: natural vulnerability, anthropogenic vulnerability and public use. For each criterion, several parameters have been identified in order to propose a detailed numerical evaluation. The results show that the degradation risk of geosites is mainly related to negligence and lack of knowledge of its inherent geological heritage, and which leads to public misuse and mismanagement of the geosites. The results give an overview of the condition of the geosites and provide information for the design and management of suitable protection measures, especially in the light of future threats related to climate change

Understanding the Excess 1/f Noise in MOSFETs at Cryogenic Temperatures

Characterization, modeling, and development of cryo-temperature CMOS technologies (cryo-CMOS) have significantly progressed to help overcome the interconnection bottleneck between qubits and the readout interface in quantum computers. Nevertheless, available compact models still fail to predict the deviation of 1/f noise from the expected linear scaling with temperature ( $\textit{T}$ ), referred to as “excess 1/f noise”, observed at cryogenic temperatures. In addition, 1/f noise represents one of the main limiting factors for the decoherence time of qubits. In this article, we extensively characterize low-frequency noise on commercial 28-nm CMOS and on research-grade Ge-channel MOSFETs at temperatures ranging from 370 K down to 4 K. Our investigations exclude electron heating and bulk dielectric defects as possible causes of the excess 1/f noise at low temperatures. We show further evidence for a strong correlation between the excess 1/f noise and the saturation of the subthreshold swing (SS) observed at low temperatures. The most plausible cause of the excess noise is found in band tail states in the channel acting as additional capture/emission centers at cryogenic temperatures

Efeitos do carprofeno no ganho de força tênsil muscular e cutânea em ratas (Rattus norvegicus) submetidas à Laparorrafia mediana

O artigo não apresenta resumo

Emprego de n-butil-cianoacrilato associado ou não à sutura na síntese de gastrotomias em ratos (Rattus norvegicus)

O artigo não apresenta resumo

POS0361 DNA METHYLATION SIGNATURES CHARACTERIZE PSORIASIS AND PSORIATIC ARTHRITIS IN MONOZYGOTIC TWINS DISCORDANT FOR THE DISEASE

Background:Psoriatic disease is a chronic inflammatory disorder spanning from skin disease (psoriasis) to psoriatic arthritis (PsA). The genetic background is insufficient to explain disease onset as illustrated by not very informative Genome Wide Association Studies and monozygotic (MZ) twin studies recently performed. It is strongly assumed that epigenetics may contribute to disease susceptibility modulating gene expression. DNA methylation has been found involved in several autoimmune inflammatory rheumatic diseases. Here we have analysed the DNA methylation profile of a selected cohort of MZ twins discordant for psoriasis/PsA.Objectives:To identify the methylome associated with psoriasis and PsA in the peripheral blood of MZ twins discordant for these conditions.Methods:Peripheral blood from 7 couples of MZ twins discordant for psoriatic disease was collected and DNA extracted for a genome-wide evaluation of the DNA methylation profile, with the Infinium MethylationEPIC BeadChip. Minfi and the packages of the Bioconductor were used to analyse the data obtained. Quality control and exclusion criteria were applied to the raw data having a final number of 762.451 probes, which accounts for 88% of the total.Results:The approach first identified 2564 differentially methylated positions (DMPs; *p<0.005) with 19 genes potentially affected (with at least two DMPs within 1 kb of distance), including SMAD3 and SMARCA4/BRG1 involved in the Interferon and TGFβ pathways. Gene Ontology (GO) analysis of DMP-associated genes showed a significative enrichment (*p<0.005) in transcription factor binding, transcription corepressor and transcription coactivator activity, SMAD binding and histone -lysine-N-methyltransferase activity. To further validate the results, 5'-methylcytosine immunoprecipitation (MedIP) followed by Real Time PCR was performed to assess the methylation level of SMAD3 and SMARCA4/BRG1 promoters in the same cohort of MZ twins. We found significantly DNA methylation enrichment in SMARCA4/BRG1 promoter in psoriatic disease twins (p<0.05). SMAD3 and SMARCA4/BRG1 mRNA expression was also assessed to evaluate any inverse correlation with promoter methylation level, on the MZ cohort used for the EPIC array (n=4) and on a cohort of PsA/Ps patients (n=8) and appropriate healthy controls (n=3). Reduced mRNA expression (p<0.05) was demonstrated for SMARCA4/BRG1 (n=4). Conversely, no changes were found for SMAD3.Conclusion:We report the first DNA methylation approach in MZ twins discordant for psoriatic disease. We believe that the observed changes in SMAD3 and SMARCA/BRG1 genes may suggest an epigenetic imbalance of chromatin remodelling factors involved in inflammation pathways with a potential role in PsA/psoriasis immunopathogenesis.Disclosure of Interests:None declare

Education is associated with lower levels of abdominal obesity in women with a non-agricultural occupation: an interaction study using China's four provinces survey

Background: The prevalence of obesity is increasing rapidly in low- and middle-income countries (LMICs) as their populations become exposed to obesogenic environments. The transition from an agrarian to an industrial and service-based economy results in important lifestyle changes. Yet different socioeconomic groups may experience and respond to these changes differently. Investigating the socioeconomic distribution of obesity in LMICs is key to understanding the causes of obesity but the field is limited by the scarcity of data and a uni-dimensional approach to socioeconomic status (SES). This study splits socioeconomic status into two dimensions to investigate how educated women may have lower levels of obesity in a context where labour market opportunities have shifted away from agriculture to other forms of employment. Methods: The Four Provinces Study in China 2008/09 is a household-based community survey of 4,314 people aged ≥60 years (2,465 women). It was used to investigate an interaction between education (none/any) and occupation (agricultural/non-agricultural) on high-risk central obesity defined as a waist circumference ≥80 cm. An interaction term between education and occupation was incorporated in a multivariate logistic regression model, and the estimates adjusted for age, parity, urban/rural residence and health behaviours (smoking, alcohol, meat and fruit & vegetable consumption). Complete case analyses were undertaken and results confirmed using multiple imputation to impute missing data. Results: An interaction between occupation and education was present (P = 0.02). In the group with no education, the odds of central obesity in the sedentary occupation group were more than double those of the agricultural occupation group even after taking age group and parity into account (OR; 95%CI: 2.21; 1.52, 3.21), while in the group with any education there was no evidence of such a relationship (OR; 95%CI: 1.25; 0.92, 1.70). Health behaviours appeared to account for some of the association. Conclusion: These findings suggest that education may have a protective role in women against the higher odds of obesity associated with occupational shifts in middle-income countries, and that investment in women’s education may present an important long term investment in obesity prevention. Further research could elucidate the mechanisms behind this association