Orman Mühendisliği Meslek Alanında Yayımlanan Orman Mühendisliği ve Yeşil Dünya Dergilerinin İncelenmesi

Bu çalışmanın amacı, Orman Mühendisleri Odası (OMO) tarafından yayımlanan ve orman mühendisliği mesleği ile ilgili olan Orman Mühendisliği ve Yeşil Dünya dergilerinin 1962-2020 yılları arasındaki sayılarının içerik olarak hangi konularda odaklandığını ortaya koymaktır. 2005-2020 yıllarının içerik analizinde ise ayrıca MAXQDA 2020 programından yararlanılmıştır. Çalışma kapsamında ele alınan 467 adet sayıda yayımlanan başlıca konular sistematik bir şekilde incelenerek içeriklerinde hangi konulara değinildiğinin ve konular arasındaki ilişkilerin değerlendirmesinde içerik analizi yöntemi kullanılmıştır. Çalışma bulguları toplamda 5245 adet konudan bahsedildiğini ve bu konuların orman mühendisliğinin alt bilim dallarıyla ilişkili olanlarının sayısının 2008, Odadan haberler-Kongreler ve Genel konularının sayısının ise 3237 olduğunu göstermektedir. Yapılan içerik analizine göre, 2005-2020 yılları arasında en çok kullanılan kelimelerin orman, mühendis, ağaç, ormancılık, toprak, tür, doğa, kanun, yangın ve mühendislik olduğu belirlenmiştir. Çalışma sonucunda Orman Mühendisliği ve Yeşil Dünya dergilerinin içerikleri ve ele alınan konular hakkında değerlendirmeler yapılmıştır. Elde edilen sonuçlara göre, dergilerde en çok OMO’nun faaliyetlerine yer verildiği görülmüştür. Yapılan içerik analizinde ise, orman mühendisi, orman yangını, orman alanı, orman ekosistemi, tohum bahçeleri vb. dikkat çekici kelime kombinasyonlarının olduğu anlaşılmıştır. OMO’nun dergilerde oda faaliyetlerini daha sade ele alarak ormancılık alanında daha fazla bilgi ve sorunlara yer vermesi önerilmektedir

The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans.

Whether extension of lifespan provides an extended time without health deteriorations is an important issue for human aging. However, to which degree lifespan and aspects of healthspan regulation might be linked is not well understood. Chromatin factors could be involved in linking both aging aspects, as epigenetic mechanisms bridge regulation of different biological processes. The epigenetic factor LIN-53 (RBBP4/7) associates with different chromatin-regulating complexes to safeguard cell identities in Caenorhabditis elegans as well as mammals, and has a role in preventing memory loss and premature aging in humans. We show that LIN-53 interacts with the nucleosome remodeling and deacetylase (NuRD) complex in C. elegans muscles to ensure functional muscles during postembryonic development and in adults. While mutants for other NuRD members show a normal lifespan, animals lacking LIN-53 die early because LIN-53 depletion affects also the histone deacetylase complex Sin3, which is required for a normal lifespan. To determine why lin-53 and sin-3 mutants die early, we performed transcriptome and metabolomic analysis revealing that levels of the disaccharide trehalose are significantly decreased in both mutants. As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway. Overall, our findings suggest that LIN-53 is required for maintaining lifespan and muscle integrity through discrete chromatin regulatory mechanisms. Since both LIN-53 and its mammalian homologs safeguard cell identities, it is conceivable that its implication in lifespan regulation is also evolutionarily conserved

Yeni Ortadoğu: Toplum, Siyaset ve Ekonomi Konferansı

Ortadoğu asırlar boyu uluslararası siyasetin merkezinde yer almış, araştırmacı ve siyaset yapıcıların ilgi odağı olmuştur. Bu ilgiye rağmen, 2010 yılında başlayan ve ‘Arap Baharı’ olarak adlandırılan halk ayaklanmaları ve bu çerçevede yaşanan siyasal, ekonomik ve sosyal dönüşümler siyasetçiler ve sosyal bilimciler tarafından öngörülememiş ve mevcut varsayımları derinden sarsmıştır. Bir yandan demokratikleşme hareketleri ve ekonomik bir dönüşüm yaşayan bölge, diğer yandan iç çatışmaların, darbelerin ve vekalet savaşlarının merkezi haline gelmiş, ve tüm bu gelişmeler yeni yaklaşımları ve analizleri gerekli kılmıştır. Bu çerçevede Işık Üniversitesi Uluslararası İlişkiler Bölümü, Arap Baharı’yla başlayan süreçte bölgede gözlemlenen yeni toplumsal, ekonomik, iç ve dış siyasal dinamikleri akademik alanda tartışmaya açmak amacıyla ‘Yeni Ortadoğu’ başlıklı bir konferans düzenledi. Bu konferans çerçevesinde 24-25 Mart 2016 tarihlerinde Maslak Kampüsü’nde bizzat sunulan ve tam metin olarak bize iletilen bildirilerden bu kitabı oluşturduk.Publisher's Versio

The relationship between osteoporosis and sarcopenia, according to EWGSOP-2 criteria, in outpatient elderly

Introduction Osteoporosis and sarcopenia are significant health problems that mainly affect older adults. This study aimed to investigate the relationship between sarcopenia and osteoporosis. Materials and methods The study included 444 participants who had undergone a dual-energy X-ray absorptiometry scan, handgrip test, 4-m walking speed test, and bioimpedance analysis within the past year. Participants were classified into control, osteopenia, or osteoporosis groups according to the World Health Organization classification. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People-2 criteria. Results The mean age of the participants was 75.88 +/- 7.20 years, and 80.9% were females. There were 144, 230, and 70 participants in the osteoporosis, osteopenia, and control groups, respectively. Probable sarcopenia was identified in 94 subjects, sarcopenia in 61, and severe sarcopenia in 72 participants. After adjusting for age, gender, and body mass index, probable sarcopenia and severe sarcopenia were associated with osteoporosis (p < 0.05). Low muscle strength, and low physical performance were associated with osteoporosis (p < 0.02). When osteoporosis was evaluated only according to the femoral neck T score, low muscle strength and low physical performance were found to be related not only to osteoporosis (p < 0.001), but also to osteopenia (p < 0.05). Additionally, probable sarcopenia was associated with femoral neck osteopenia (p < 0.01). Conclusions In this study, probable sarcopenia and severe sarcopenia were associated with osteoporosis in older adults. Furthermore, we found that low muscle strength, or dynapenia, which is the determining criterion of sarcopenia, was related to femoral neck osteopenia and osteoporosis

Orthostatic hypotension in dementia with Lewy bodies: a meta-analysis of prospective studies.

PurposeOrthostatic hypotension (OH), one of the supportive clinical features in the diagnosis of dementia with Lewy bodies (DLB), is a significant problem in advanced age because of its severe negative consequences. The aim of this meta-analysis was to investigate the prevalence and risk of OH in patients with DLB.MethodsThe indexes and databases cited to identify relevant studies were PubMed, ScienceDirect, Cochrane, and Web of Science. The keywords for the search were "Lewy body dementia" and "autonomic dysfunction" or "dysautonomia" or "postural hypotension" or "orthostatic hypotension." English-language articles published from January 1990 to April 2022 were searched. The Newcastle-Ottawa scale was applied to evaluate the quality of the studies. Odds ratios (OR) and risk ratios (RR) were extracted with 95% confidence intervals (CI) and combined using the random effects model after logarithmic transformation. The prevalence in the patients with DLB was also combined using the random effects model.ResultsEighteen studies (10 case controls and 8 case series) were included to evaluate the prevalence of OH in patients with DLB. Higher rates of OH were found to be associated with DLB (OR 7.71, 95% CI 4.42, 13.44; p < 0.001), and 50.8% of 662 patients had OH.ConclusionDLB increased the risk of OH by 3.62- to 7.71-fold compared to healthy controls. Therefore, it will be useful to evaluate postural blood pressure changes in the follow-up and treatment of patients with DLB

Validation of the Turkish version of the Lewy body composite risk score

The Lewy Body Composite Risk Score (LBCRS) has been developed to increase the sensitivity and specificity of the diagnosis attributable to Lewy body pathology outside of specialty centers. We aimed to assess the validity and reliability of the Turkish version of the LBCRS in patients with dementia with Lewy Bodies (DLB) and investigate the discriminative power of the test in Turkish patients with Alzheimer’s disease (AD) and DLB, and control group. The sample population (n = 512) comprised DLB (n = 113), DLB-Mild Cognitive Impairment (MCI)(n = 12), AD (n = 42), AD-MCI (n = 21), and control group (n = 324). A significant group difference was observed in the Turkish version of the LBCRS scores of the five groups (p 1. In patients with DLB, the cutoff score of ≥3 showed sensitivity (92%) and specificity (81%) (area under the curve [AUC] = 0.883, 95% CI: 0.815–0.951), p <.001) compared with the AD. Compared to the control group, the cutoff score of ≥3 showed a sensitivity of 98% and specificity of 97% (AUC = 0.994, 95% CI: 0.989–0.999, p <.001). The Turkish version of LBCRS permits accurate diagnosis of DLB with high sensitivity and specificity. Also, it can be useful to inform the caregivers regarding the course of the disease during the follow-up

Hyperuricemia may be associated with muscle wellness in older adults

Purpose: Sarcopenia, associated with morbidity and mortality, is a common geriatric syndrome in older adults. In this study, we investigated the relationship between uric acid, which is a powerful antioxidant and has intracellular proinflammatory activity, and sarcopenia in older adults. Methods: This is a cross-sectional retrospective study involving a total of 936 patients. The diagnosis of sarcopenia was evaluated based on the EGWSOP 2 criteria. The patients were divided into two groups according to hyperuricemia (for females > 6 mg/dl, for males > 7 mg/dl); hyperuricemia and control. Results: The frequency of hyperuricemia was 65.40%. Patients with hyperuricemia were older than the control group and female gender frequency was higher (p = 0.001, p < 0.001, respectively). Sarcopenia was negatively associated with hyperuricemia as a result of the adjustment analysis made according to demographic characteristics, comorbidities, laboratory results, malnutrition, and malnutrition risk. (p = 0.034). Besides, muscle mass and muscle strength were associated with hyperuricemia (p = 0.026 and p = 0.009, respectively). Conclusions: Considering the positive effect of hyperuricemia on sarcopenia, avoiding aggressive uric acid-lowering therapy may be a good option in older adults with asymptomatic hyperuricemia

Orthostatic hypotension in patients with Alzheimer's disease: a meta-analysis of prospective studies.

Background Orthostatic hypotension (OH) is a clinical sign associated with severe adverse health outcomes in older adults. It has been reported to be common in patients with Alzheimer's disease (AD). The present meta-analysis aimed to investigate the prevalence and risk of OH in AD patients. Methods English-language articles published from January 1990 to August 2020 were searched in PubMed, ScienceDirect, Cochrane, and Web of Science with the keywords "Alzheimer" and "autonomic dysfunction" or "dysautonomia" or "postural hypotension" or "orthostatic hypotension." All prospective clinical studies (case-control, cohort, and cross-sectional studies, and randomized controlled trials) that were regarded as pertinent were included in this study. For quality assessment, the Newcastle-Ottawa Scale was used. Odds ratios (OR) and risk ratios (RR) were extracted with 95% confidence intervals (CI) and combined using the random effects model after logarithmic transformation. The prevalence in the AD patients was also combined using the random effects model. Results The meta-analysis involved 11 studies (7 case-control and 4 case series) to assess the risk of OH in AD. It was found that AD increased the risk of OH with an RR of 1.98 (95% CI: 0.97-4.04) and an OR of 2.53 (95% CI:1.10-5.86) compared to healthy controls, and OH was present in 28% (95% CI: 0.17-0.40) of 500 AD patients. Conclusion There is an elevated risk of OH in AD by nearly 2.5-fold. Therefore, the evaluation of postural blood pressure changes should definitely be among the follow-up and treatment goals of AD