Separated flow

A brief overview of flow separation phenomena is provided. Langley has many active research programs in flow separation related areas. Three cases are presented which describe specific examples of flow separation research. In each example, a description of the fundamental fluid physics and the complexity of the flow field is presented along with a method of either reducing or controlling the extent of separation. The following examples are discussed: flow over a smooth surface with an adverse pressure gradient; flow over a surface with a geometric discontinuity; and flow with shock-boundary layer interactions. These results will show that improvements are being made in the understanding of flow separation and its control

A regulator of G Protein signaling, RGS3, inhibits gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) secretion

BACKGROUND: Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope responsiveness to hypothalamic gonadotropin releasing hormone and by alterations in gonadotropin releasing hormone secretion. The mechanisms that determine gonadotrope responsiveness are unknown but may involve regulators of G protein signaling (RGSs). These proteins act by antagonizing or abbreviating interaction of Gα proteins with effectors such as phospholipase Cβ. Previously, we reported that gonadotropin releasing hormone-stimulated second messenger inositol trisphosphate production was inhibited when RGS3 and gonadotropin releasing hormone receptor cDNAs were co-transfected into the COS cell line. Here, we present evidence for RGS3 inhibition of gonadotropin releasing hormone-induced luteinizing hormone secretion from cultured rat pituitary cells. RESULTS: A truncated version of RGS3 (RGS3T = RGS3 314–519) inhibited gonadotropin releasing hormone-stimulated inositol trisphosphate production more potently than did RSG3 in gonadotropin releasing hormone receptor-bearing COS cells. An RSG3/glutathione-S-transferase fusion protein bound more (35)S-Gqα than any other member of the G protein family tested. Adenoviral-mediated RGS3 gene transfer in pituitary gonadotropes inhibited gonadotropin releasing hormone-stimulated luteinizing hormone secretion in a dose-related fashion. Adeno-RGS3 also inhibited gonadotropin releasing hormone stimulated (3)H-inositol phosphate accumulation, consistent with a molecular site of action at the Gqα protein. CONCLUSIONS: RGS3 inhibits gonadotropin releasing hormone-stimulated second messenger production (inositol trisphosphate) as well as luteinizing hormone secretion from rat pituitary gonadotropes apparently by binding and suppressing the transduction properties of Gqα protein function. A version of RGS3 that is amino-terminally truncated is even more potent than intact RGS3 at inhibiting gonadotropin releasing hormone-stimulated inositol trisphosphate production

Banking from Leeds, not London: regional strategy and structure at the Yorkshire Bank, 1859–1952

Industrial philanthropist Edward Akroyd created the Yorkshire Penny Savings Bank in 1859. Despite competition from the Post Office Savings Bank after 1861 and a serious reserve problem in 1911, it sustained his overall strategy to become a successful regional bank. Using archival and contemporary sources to build on recent scholarship illustrating how savings banks were integrated into local economies and the complementary roles of philanthropy and paternalism, we analyse an English regional bank's strategy, including an assessment of strategic innovation, ownership changes and management structure. This will demonstrate that the founder's vision continued, even though the 1911 crisis radically altered both strategy and structure

Performance and Carcass Traits of Market Beef Cattle Supplemented Self-Fed Byproducts on Pasture: Final Report

Over a two year period (2007 and 2008), 162 head of beef steers were finished with self-fed byproducts on cool season grass pastures. Yearling steers were continuously grazed at the Neely-Kinyon Farm in southwest Iowa on cool season grasses that were predominantly fescue at a stocking density of 2.25 head/acre. Half of the cattle were implanted (with Synovex®-S) or half were not. Cattle received a diet of either soyhulls-dried distillers grain with solubles (DDGS) or ground corn-dried distillers grains with solubles that was offered through self-feeders. The rations were mixed at a 1:1 ratio with a mineral balancer added which included Rumensin®. Live cattle performance and carcass traits were not affected by diet. Implanted cattle outgained non-implanted over the entire finishing period (3.52 lbs/d vs. 3.17 lbs/d). This led to implanted cattle coming off test heavier (1324 lbs vs. 1277 lbs) and railing with heavier carcasses (826 lbs vs. 800 lbs). Ribeye areas were greater (13.1 in2 vs. 12.7 in2) for implanted cattle; which was probably due to the heavier carcass weights. Non-implanted cattle had superior quality grades (55% vs. 40%) of low choice or better. Fatty acid profiles from the first year were analyzed and showed that raw beef samples from cattle on the soyhulls diet had significantly higher C18:2 In conclusion, pasture rearing cattle, when given access to self-fed by-products, provides for excellent performance on both live performance and carcass traits. Some considerations should be made by the feeder in regards to time of year when marketing cattle and the cattle’s genetics. This system is an alternative to high-grain conventional beef finishing production in feedlots

Performance and Carcass Traits of Market Beef Cattle Supplemented Self-Fed Byproducts on Pasture: A Progress Report

Over a two year period (2007 and 2008), 162 head of beef steers were finished with self-fed byproducts on cool season grass pastures. Yearling steers were continuously grazed at the Neely-Kinyon Farm in southwest Iowa on cool season grasses that were predominantly fescue at a stocking density of 2.25 head/acre. Half of the cattle were implanted (with Synovex®-S) or and half were not. Cattle received a diet of either soyhulls-dried distillers grain with solubles or corn-dried distillers grains with solubles (DDGS) that was offered as a meal through self-feeders. The rations were mixed in at 1:1 with a mineral balancer that included Rumensin®. Live cattle performance and carcass traits were not affected by diet. Implanted cattle outgained non-implanted over the entire finishing period (3.52 lbs/d vs. 3.17 lbs/d). This led to implanted cattle coming off test heavier (1324 lbs vs. 1277 lbs) and railing with heavier carcasses (826 lbs vs. 800 lbs). Ribeye areas were greater (13.1 in 2 vs. 12.7 in 2 ) for implanted cattle; which was probably due to the heavier carcass weights. Non-implanted cattle had superior quality grades (55% vs. 40%) of low choice or better. Year differences in quality grade (1023 vs. 985 in 2007 and 2008, respectively) were observed. This difference was attributed to factors that include genetic makeup of cattle, initial weights of cattle, time of year when cattle were harvested and grading technology. In conclusion, pasture rearing cattle, when given access to self-fed by-products, provides for excellent performance on both live performance and carcass traits. Some considerations should be made by the feeder in regards to time of year when marketing cattle and the cattle’s genetics. This system is an alternative to high-grain conventional beef finishing production in feedlots

Mutation-aware fault prediction

We introduce mutation-aware fault prediction, which leverages additional guidance from metrics constructed in terms of mutants and the test cases that cover and detect them. We report the results of 12 sets of experiments, applying 4 di↵erent predictive modelling techniques to 3 large real world systems (both open and closed source). The results show that our proposal can significantly (p 0.05) improve fault prediction performance. Moreover, mutation based metrics lie in the top 5% most frequently relied upon fault predictors in 10 of the 12 sets of experiments, and provide the majority of the top ten fault predictors in 9 of the 12 sets of experiments.http://www0.cs.ucl.ac.uk/staff/F.Sarro/resource/papers/ISSTA2016-Bowesetal.pd

Multibody dynamics analysis (MDA) as a numerical modelling tool to reconstruct the function and palaeobiology of extinct organisms

Recent advances in computer technology have substantially changed the field of palaeontology in the last two decades. Palaeontologists now have a whole new arsenal of powerful digital techniques available to study fossil organisms in unprecedented detail and to test hypotheses regarding function and behaviour. Multibody dynamics analysis (MDA) is one of these techniques and although it originated as a tool used in the engineering and automotive industry, it holds great potential to address palaeontological questions as well. MDA allows the simulation of dynamic movements in complex objects consisting of multiple linked components. As such, this technique is ideally suited to model biological structures and to obtain quantifiable results that can be used to test the function of musculoskeletal systems rigorously. However, despite these advantages, MDA has seen a slow uptake by the palaeontological community. The most likely reason for this lies in the steep learning curve and complexity of the method. This paper provides an overview of the underlying principles of MDA and outlines the main steps involved in conducting analyses. A number of recent studies using MDA to reconstruct the palaeobiology of fossil organisms are presented and the potential for future studies is discussed. Similar to other computational techniques, including finite element analysis and computational fluid dynamics, the non‐invasive and exploratory power of MDA makes it ideally suited to study the form and function in vertebrates for which no modern analogues exist

Future directions for the management of pain in osteoarthritis.

Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA in the long term. Current treatments are largely based on the modulation of pain, including NSAIDs, opiates and, more recently, centrally acting pharmacotherapies to avert pain. This review will focus on the rationale for new avenues in pain modulation, including inhibition with anti-NGF antibodies and centrally acting analgesics. The authors also consider the potential for structure modification in cartilage/bone using growth factors and stem cell therapies. The possible mismatch between structural change and pain perception will also be discussed, introducing recent techniques that may assist in improved patient phenotyping of pain subsets in OA. Such developments could help further stratify subgroups and treatments for people with OA in future

Radiation tolerance of GaAs1-xSbx solar cells

High radiation tolerance of GaAs1-xSbx based solar cells is demonstrated for the low-intensity-low-temperature (LILT) conditions of the target planets Saturn, Jupiter, and Mars. The GaAs1-xSbx-based cells are irradiated with high energy electrons to assess the effect of harsh radiation environment on the solar cell and the response of the cell is then investigated in terms of its photovoltaic operation. This system shows significant radiation resistance to the high energy electron environment for the conditions of the planets of interest. An unusual increase of the short circuit current after irradiation is observed at low temperature, which is supported by a simultaneous increase in the external quantum efficiency of the cell under the same conditions. The open circuit voltage and fill factor of the cell are especially tolerant to irradiation, which is also reflected in unchanged dark current-voltage characteristics of the solar cell upon irradiation particularly at LILT

Radiation tolerance of GaAs1-xSbx solar cells: A candidate III-V system for space applications

The high radiation tolerance of GaAs0.86Sb0.14 based solar cells with a band gap suitable for PV is demonstrated at the low intensity low temperature (LILT) conditions. This system shows remarkable radiation hardness at AM0, and more prominently, at the conditions of several outer planetary targets. This is attributed to an irradiation induced change in the absorber band gap due to local heating and strain relaxation, and the generation of less prohibitive shallow Sb-based defects in the GaAs 1-x Sb x absorber