555 research outputs found
Issues in the study of utero-placental blood flow in severe gestosis
The complications of pregnancy, gestosis particularly, are still important aspects on the modern stage of development of obstetrics, as it influences on development of maternal and perinatal morbidity and mortality. One hundred and twenty-five patients with severe gestosis were studied. The conditions of myometrium, endometrium, placenta, umbilical chord as well as erythrocytes of maternal blood were explored with help of atomic power microscopy, light microscopy as well as electron microscop
ΠΠ΅Π½Π΄Π΅ΡΠ½Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ Π²ΡΠΊΡΠΈΠΌΠ½ΠΎΡΡΡ ΠΏΡΠ΄Π»ΡΡΠΊΡΠ²
Shevchenko, L.A. and Selivanova, O.I. (2015), βGender features of teenagersβ victimityβ [βHenderni
osoblyvosti viktymnosti pidlitkivβ], Pravo i Bezpeka, No. 3, pp. 166β169.Π¨Π΅Π²ΡΠ΅Π½ΠΊΠΎ, Π. Π. ΠΠ΅Π½Π΄Π΅ΡΠ½Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ Π²ΡΠΊΡΠΈΠΌΠ½ΠΎΡΡΡ ΠΏΡΠ΄Π»ΡΡΠΊΡΠ² / Π. Π. Π¨Π΅Π²ΡΠ΅Π½ΠΊΠΎ, Π. Π. Π‘Π΅Π»ΡΠ²Π°Π½ΠΎΠ²Π° // ΠΡΠ°Π²ΠΎ Ρ Π±Π΅Π·ΠΏΠ΅ΠΊΠ°. - 2015. - β 3 (58). - Π‘. 166β169.ΠΡΠΎΠ°Π½Π°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΎ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ ΡΠΈΠ½Π½ΠΈΠΊΠΈ ΠΉ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ Π²ΡΠΊΡΠΈΠΌΠ½ΠΎΡ ΠΏΠΎΠ²Π΅Π΄ΡΠ½ΠΊΠΈ Π² ΠΏΡΠ΄Π»ΡΡΠΊΠΎΠ²ΠΎΠΌΡ Π²ΡΡΡ.
Π ΠΎΠ·Π³Π»ΡΠ½ΡΡΠΎ Π²Π½ΡΡΡΡΡΠ½Ρ Π΄Π΅ΡΠ΅ΡΠΌΡΠ½Π°Π½ΡΠΈ Π²ΡΠΊΡΠΈΠΌΠ½ΠΎΡΡΡ. ΠΡΠΎΠ±Π»ΠΈΠ²Ρ ΡΠ²Π°Π³Ρ ΠΏΡΠΈΠ΄ΡΠ»Π΅Π½ΠΎ Π³Π΅Π½Π΄Π΅ΡΠ½ΡΠΉ ΡΠΏΠ΅ΡΠΈΡΡΡΡ ΠΏΡΠΎΡΠ²Ρ Π²ΡΠΊΡΠΈΠΌΠ½ΠΎΡ ΠΏΠΎΠ²Π΅Π΄ΡΠ½ΠΊΠΈ Π² ΠΏΡΠ΄Π»ΡΡΠΊΠΎΠ²ΠΎΠΌΡ Π²ΡΡΡ. ΠΠΈΡΠ²ΡΡΠ»Π΅Π½ΠΎ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΡΠΎΠ΄ΠΎ ΠΏΡΠΎΡΡΠ»Π°ΠΊΡΠΈΡΠ½ΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ Π· ΠΏΠΎΠΏΠ΅ΡΠ΅Π΄ΠΆΠ΅Π½Π½Ρ Π²ΡΠΊΡΠΈΠΌΠ½ΠΎΡΡΡ.The features of teenagersβ victimity considering gender component are analyzed. It is indicated that
victimity has internal determinants such as psychodynamic basic characteristics of personality, reflecting an individual level of its functioning and programmable properties that form the content and
semantic programs of behavior and activities of a human being, as well as external, which are a set of
social conditions that have victimological potential.
Teenagerβs victimity occurs in the process of victimization. It is revealed that realized boysβ victimity
is higher than girlsβ one. Boys more often than girls suffer physical violence from parents, older boys
and their peers, addicted to actively victim behavior and aggressive victim behavior, often deliberately create or provoke conflicts. They at a conscious level deny the existence of victimological qualities
that really is not true. The model of passive victim behavior is inherent for girls in comparison with
their boys-peers, who suffered psychological violence more often from both parents and peers. Despite the more critical attitude to themselves the most characteristic features of their behavior are addiction, fear of responsibility, setting for the helplessness, reconciliation with the role of a victim.
Preventive measures concerning victim behavior of teenagers must have comprehensive nature,
however, for girls and boys may need different preventive measures that promote the prevention of
their victim behavior. The main tasks of prevention of teenagersβ victimity are to identify and consolidate the positive personality qualities, formation of the ability to make their own choices, sense of
responsibility, timely resolution of conflicts.ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°ΠΊΡΠΎΡΡ ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π²ΠΈΠΊΡΠΈΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π² ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ²ΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ΅. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΠ΅ Π΄Π΅ΡΠ΅ΡΠΌΠΈΠ½Π°Π½ΡΡ Π²ΠΈΠΊΡΠΈΠΌΠ½ΠΎΡΡΠΈ. ΠΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅
ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π³Π΅Π½Π΄Π΅ΡΠ½ΠΎΠΉ ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π²ΠΈΠΊΡΠΈΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π² ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ²ΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ΅.
ΠΡΠ²Π΅ΡΠ΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ°ΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΏΠΎ ΠΏΡΠ΅Π΄ΡΠΏΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ Π²ΠΈΠΊΡΠΈΠΌΠ½ΠΎΡΡΠΈ
Limit cycles of orthogonal projection onto the set of the most remote
The problem of finding the limit polygonal cycles of orthogonal projection onto the most remote set in the plane is discussed. As a simplest case we have considered projections onto the remote side of the triangle. A criterion of existence and analytical formulas for limit triangular cycles is described. We construct the set of initial points of the sequence converging to the triangular cycle. The examples of limit polygonal cycles are presented. Numerical calculations are performed.Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Π° Π·Π°Π΄Π°ΡΠ° Π½Π°Ρ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΡΠ΅Π΄Π΅Π»ΡΠ½ΡΡ
ΠΌΠ½ΠΎΠ³ΠΎΡΠ³ΠΎΠ»ΡΠ½ΡΡ
ΡΠΈΠΊΠ»ΠΎΠ² ΠΏΡΠΈ ΠΎΡΡΠΎΠ³ΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π½Π° Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠ΅ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ ΠΈΠ· ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΠ³ΠΎ Π½Π°Π±ΠΎΡΠ° Π²ΡΠΏΡΠΊΠ»ΡΡ
ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠ½ΡΡ
ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ² Π½Π° ΠΏΠ»ΠΎΡΠΊΠΎΡΡΠΈ. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΡΠΎΡΡΠ΅ΠΉΡΠ΅Π³ΠΎ ΡΠ»ΡΡΠ°Ρ ΠΏΠΎΡΡΡΠΎΠ΅Π½Ρ ΠΏΡΠ΅Π΄Π΅Π»ΡΠ½ΡΠ΅ ΡΠΈΠΊΠ»Ρ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ΄Π°Π»Π΅Π½Π½ΡΡ ΡΡΠΎΡΠΎΠ½Ρ ΡΡΠ΅ΡΠ³ΠΎΠ»ΡΠ½ΠΈΠΊΠ°. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΊΡΠΈΡΠ΅ΡΠΈΠΉ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΈ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΡΠΌΡΠ»Ρ Π΄Π»Ρ ΠΏΡΠ΅Π΄Π΅Π»ΡΠ½ΡΡ
ΡΡΠ΅ΡΠ³ΠΎΠ»ΡΠ½ΡΡ
ΡΠΈΠΊΠ»ΠΎΠ². ΠΠΏΠΈΡΠ°Π½ΠΎ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ Π½Π°ΡΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΠ΅ΠΊ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΡΡ
ΠΎΠ΄ΡΡΠ΅ΠΉΡΡ ΠΊ ΡΡΠ΅ΡΠ³ΠΎΠ»ΡΠ½ΠΎΠΌΡ ΡΠΈΠΊΠ»Ρ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΏΡΠΈΠΌΠ΅ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ³ΠΎΠ»ΡΠ½ΡΡ
ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠ½ΡΡΡΠΎΠ². ΠΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΡΠ°ΡΡΠ΅ΡΡ Π΄Π»Ρ ΡΡΠ΅ΡΠ³ΠΎΠ»ΡΠ½ΠΈΠΊΠΎΠ²
A Comprehensive Diagnosis of Components of Pedagogical Studentsβ Research Competency
Introduction. Nowadays, the aspects of development of research competencies in future experts belong to the most relevant topics, which are widely being discussed both in Russian and in foreign scientific community. One of burning issues in this thematic block is diagnosis of such competencies without which their successful development is impossible. Today, we are witnessing the disparity between a large number of the methods presented in scientific sources and technologies of the formation of studentsβ research competency and limitation of its criteria and indicators. Moreover, there is lack of adequate methodological tools to estimate objectively the level and quality of scientific literacy and degree of studentsβ research activity.The aim of the research was to define the content of a comprehensive diagnosis of the components of pedagogical studentsβ research competency and to justify the criteria, indicators and methods of its evaluation. Methodology and research methods. The methods of analysis, synthesis, generalisation and modelling were employed. The systematic approach was applied, taking into account the provisions of plurality, integrity and structurisation. Results and scientific novelty. The authors presented and described the model of formation of pedagogical studentsβ practice-focused research competency. The knowledge-based, value-oriented and practical components of the model are correlated to the methods of psycho-pedagogical monitoring, which are relevant to the content of these components. The complex of particular techniques for comprehensive, precise and complete assessment of future teachersβ research competency is designed. The complexity of measurement tools is provided with homogeneity between a theoretical construct (research competency) and operationalised constructs (psychological phenomena estimated in diagnostic techniques). Cumulative application of the selected diagnostic procedures and techniques allows: objective and subjective indicators of formation of research abilities and skills to be compared; motivation and readiness of students for implementation of independent research activity to be defined, taking into account social and professional contexts of its realisation. Practical significance. The authors of the present publication propose to introduce into practice of the higher school the approaches to contents, structure and organisation of the psychological diagnostics of level of studentsβ research competency, which will give the chance not only to carry out the internal regular and continuous monitoring of formation of one of key characteristics of the identity of the modern expert in educational institutions, but also to optimise the process of multilevel high school preparation, having adjusted work on early identification of its problems and crisis stages to take timely effective correctional measures.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. Π Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ, ΠΊΠ°ΡΠ°ΡΡΠΈΠΌΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΡΠ΅ΠΉ ΡΠΊΠΎΠ»Ρ ΡΠ΅ΠΌΠ°ΠΌ, ΡΠΈΡΠΎΠΊΠΎ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΠΈΠΌΡΡ ΠΊΠ°ΠΊ Π² ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΌ, ΡΠ°ΠΊ ΠΈ Π² Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΠΎΠΌ Π½Π°ΡΡΠ½ΠΎΠΌ ΡΠΎΠΎΠ±ΡΠ΅ΡΡΠ²Π΅, ΠΎΡΠ½ΠΎΡΡΡΡΡ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΡ Π±ΡΠ΄ΡΡΠΈΠΌΠΈ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠ°ΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ. ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΎΡΡΡΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ Π² Π΄Π°Π½Π½ΠΎΠΌ ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ Π±Π»ΠΎΠΊΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΡΠ°ΠΊΠΎΠ³ΠΎ ΡΠΎΠ΄Π° ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ, Π±Π΅Π· ΠΊΠΎΡΠΎΡΠΎΠΉ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΈΡ
ΡΡΠΏΠ΅ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π½Π΅ΡΠΎΡΠ°Π·ΠΌΠ΅ΡΠ½ΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ³ΡΠΎΠΌΠ½ΡΠΌ ΡΠΈΡΠ»ΠΎΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π² Π½Π°ΡΡΠ½ΡΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ°Ρ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΠΎΡΡΡΡ Π΅Π΅ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°ΡΠΈΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ Π½Π°ΡΡΠ½ΠΎΠΉ Π³ΡΠ°ΠΌΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ. Π¦Π΅Π»Ρ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠΉ Π² ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ°Π±ΠΎΡΡ β ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΈ Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°ΡΡ Π²ΡΠ±ΠΎΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ Π΅Π΅ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ. ΠΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π² Ρ
ΠΎΠ΄Π΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΠΌΠ΅ΡΠΎΠ΄Ρ Π°Π½Π°Π»ΠΈΠ·Π°, ΡΠΈΠ½ΡΠ΅Π·Π°, ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ΠΈΡ ΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Ρ ΠΎΠΏΠΎΡΠΎΠΉ Π½Π° ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄, Π±Π°Π·ΠΈΡΡΡΡΠΈΠΉΡΡ Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡΡ
ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ, ΡΠ΅Π»ΠΎΡΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΡΡΡΠΊΡΡΡΠΈΠ·Π°ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ Π½Π°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π°. ΠΠΏΠΈΡΠ°Π½Π° Π°Π²ΡΠΎΡΡΠΊΠ°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΎ-ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΈ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΡΡΠ΅ΠΉ. Π‘ΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»Ρ Π·Π½Π°Π½ΠΈΠ΅Π²ΡΠΉ, ΡΠ΅Π½Π½ΠΎΡΡΠ½ΡΠΉ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ ΡΠΎΠΎΡΠ½Π΅ΡΠ΅Π½Ρ Ρ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΎ-ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π°, ΡΠ΅Π»Π΅Π²Π°Π½ΡΠ½ΡΠΌΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΡΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ². Π‘ΠΊΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ Π΄Π»Ρ Π²ΡΠ΅ΡΡΠΎΡΠΎΠ½Π½Π΅ΠΉ, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ ΡΠΎΡΠ½ΠΎΠΉ ΠΈ ΠΏΠΎΠ»Π½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΈ Π±ΡΠ΄ΡΡΠΈΡ
ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΎΠ². ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΡΡΡ ΠΈΠ·ΠΌΠ΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°ΡΠΈΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ Π³ΠΎΠΌΠΎΠ³Π΅Π½Π½ΠΎΡΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΎΠΌ (ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠ΅ΠΉ) ΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠ°ΠΌΠΈ (ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅Π½ΠΎΠΌΠ΅Π½Π°ΠΌΠΈ, ΠΎΡΠ΅Π½ΠΈΠ²Π°Π΅ΠΌΡΠΌΠΈ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ°Ρ
). Π‘ΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΎΡΠΎΠ±ΡΠ°Π½Π½ΡΡ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅Π΄ΡΡ ΠΈ ΡΠ΅Ρ
Π½ΠΈΠΊ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠΎΠΏΠΎΡΡΠ°Π²Π»ΡΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈ ΡΡΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
ΡΠΌΠ΅Π½ΠΈΠΉ, Π½Π°Π²ΡΠΊΠΎΠ² ΠΈ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠ΅ΠΉ; ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΡ ΠΈ Π³ΠΎΡΠΎΠ²Π½ΠΎΡΡΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΊ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Ρ ΡΡΠ΅ΡΠΎΠΌ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠΎΠ² Π΅Π΅ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ. ΠΠ½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΡ Π²ΡΡΡΠ΅ΠΉ ΡΠΊΠΎΠ»Ρ ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌΡΡ
Π°Π²ΡΠΎΡΠ°ΠΌΠΈ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ, ΡΡΡΡΠΊΡΡΡΠ΅ ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΡΠΎΠ²Π½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π² ΡΡΠ΅Π±Π½ΡΡ
Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΡΡ
Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠ½ΡΠΉ ΠΏΠΎΠ»Π½ΠΎΡΠ΅Π½Π½ΡΠΉ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΊΠ»ΡΡΠ΅Π²ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ Π»ΠΈΡΠ½ΠΎΡΡΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠ°, Π½ΠΎ ΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΡΠ΅ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΡΠΎΠ²Π½Π΅Π²ΠΎΠΉ Π²ΡΠ·ΠΎΠ²ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ, Π½Π°Π»Π°Π΄ΠΈΠ² ΡΠ°Π±ΠΎΡΡ ΠΏΠΎ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΌΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π΅Π³ΠΎ ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΠΈ ΠΊΡΠΈΠ·ΠΈΡΠ½ΡΡ
ΡΡΠ°ΠΏΠΎΠ² Π΄Π»Ρ ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΠ½ΡΡΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΌΠ΅Ρ.the Russian Foundation for Basic Research, project β18β013β00268 A βFormation of Studentsβ Research Competencies of the System of Multilevel Psycho-Pedagogical Education and Vocational Development of Pedagogical Personnel in Higher Educational InstitutionβΠ Π€Π€Π Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ΅ΠΊΡΠ° β18β013β00268 Π Β«Π€ΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΌΠ½ΠΎΠ³ΠΎΡΡΠΎΠ²Π½Π΅Π²ΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΎ-ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ°Π΄ΡΠΎΠ²
Leonardo da Vinciβs ceativity and attention deficit hyperactivity disorder
The article discusses a correlation between the character and life of Leonardo da Vinci and possible manifestations of his attention deficit disorder
The Maupertuis principle and canonical transformations of the extended phase space
We discuss some special classes of canonical transformations of the extended
phase space, which relate integrable systems with a common Lagrangian
submanifold. Various parametric forms of trajectories are associated with
different integrals of motion, Lax equations, separated variables and
action-angles variables. In this review we will discuss namely these induced
transformations instead of the various parametric form of the geometric
objects
Canonical transformations of the extended phase space, Toda lattices and Stackel family of integrable systems
We consider compositions of the transformations of the time variable and
canonical transformations of the other coordinates, which map completely
integrable system into other completely integrable system. Change of the time
gives rise to transformations of the integrals of motion and the Lax pairs,
transformations of the corresponding spectral curves and R-matrices. As an
example, we consider canonical transformations of the extended phase space for
the Toda lattices and the Stackel systems.Comment: LaTeX2e + Amssymb, 22p
ΠΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠ΅Π½ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠΎΡΠΌΡ Π² Π ΠΎΡΡΠΈΠΈ
Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΠΊΡΡΡΠ° ΡΡΡΡ ΠΏΠ΅Π½ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠΎΡΠΌΡ Π² Π Π€. ΠΠΎΠΊΠ°Π·Π°Π½Ρ Π΅Π΅ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ Π½ΠΎΠ²ΠΎΠ²Π²Π΅Π΄Π΅Π½ΠΈΠΉ
ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π΄ΠΈΠ³ΠΈΠ΄ΡΠΎΠΊΠ²Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΈ Π΅Π³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² Ρ ΡΠΈΠΊΠ»ΠΎΠΎΠΊΡΠΈΠ³Π΅Π½Π°Π·ΠΎΠΉ-2
Background. Dihydroquercetin (DHQ) is a natural flavonoid. It has a wide range of pharmacological effects, which includes anti-inflammatory activity. There is a gap in our knowledge about the biochemical mechanisms of the therapeutic potency implementation of this compound. This fact slows down the process of the drug development using DHQ. Molecular modeling is designed to further translate the research from the fundamental experimentation to the real clinical practice. Purpose. The study objective was to estimate DHQ as a cyclooxygenase-2 (COX-2) inhibitor by using in silico analysis.Materials and methods. The information about the COX-2 structure was obtained from the Protein Data Bank (code 5KIR). The 3D-models of DHQ were generated by using the ChemBioDraw Ultra software. Docking was carried out in the GOLD program after the corresponding validation of molecular modeling algorithms based on experimental data of X-ray diffraction analysis.Results. The design of this study is based on the rational selecting of the virtual ligand structures. It gives an opportunity to optimize the quantum-mechanical calculation. By using in silico analysis, it was shown that DHQ and some of its metabolites demonstrate ability of binding to SER353, SER530, and ARG513 of COX-2 at the catalytic site.Conclusion. Important Ξ±-amino acids for intermolecular interaction of DHQ and its metabolites with COX-2 were determined during this study. Our data can be used for the development of new antiinflammatory drugs on the base of DHQ.Β ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠΈΠ³ΠΈΠ΄ΡΠΎΠΊΠ²Π΅ΡΡΠ΅ΡΠΈΠ½ (ΠΠΠ) β ΠΏΡΠΈΡΠΎΠ΄Π½ΡΠΉ ΡΠ»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ Ρ ΡΠΈΡΠΎΠΊΠΈΠΌ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
. ΠΡΡΡΡΡΡΠ²ΠΈΠ΅ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΡΡΡ
ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π·Π°ΠΌΠ΅Π΄Π»ΡΠ΅Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½Π° Π΅Π³ΠΎ ΠΎΡΠ½ΠΎΠ²Π΅. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈΠ·Π²Π°Π½ΠΎ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΡΠ°Π½ΡΠ»ΡΡΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈΠ· ΠΎΠ±Π»Π°ΡΡΠΈ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π°ΡΠΊΠΈ Π² ΠΎΠ±Π»Π°ΡΡΡ ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΎΡΠ΅Π½ΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΠΠ ΠΊΠ°ΠΊ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ° ΡΠΈΠΊΠ»ΠΎΠΎΠΊΡΠΈΠ³Π΅Π½Π°Π·Ρ-2 (Π¦ΠΠ-2) ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ in siliΡo.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΡΡΡΡΠΊΡΡΡΠ΅ Π¦ΠΠ-2 ΠΏΠΎΠ»ΡΡΠ΅Π½Π° ΠΈΠ· Π±Π°Π·Ρ Π΄Π°Π½Π½ΡΡ
Protein Data Bank (ΠΊΠΎΠ΄ ΡΡΡΡΠΊΡΡΡΡ: 5KIR). 3D-ΠΌΠΎΠ΄Π΅Π»ΠΈ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ² ΡΠ³Π΅Π½Π΅ΡΠΈΡΠΎΠ²Π°Π½Ρ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ ChemBioDraw Ultra. ΠΠΎΠΊΠΈΠ½Π³ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ GOLD ΠΏΠΎΡΠ»Π΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΉ Π²Π°Π»ΠΈΠ΄Π°ΡΠΈΠΈ Π°Π»Π³ΠΎΡΠΈΡΠΌΠΎΠ² ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Γ½ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΈΠ·Π°ΠΉΠ½ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±Π°Π·ΠΈΡΠΎΠ²Π°Π»ΡΡ Π½Π° ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π΅ ΠΊ Π²ΡΠ±ΠΎΡΡ Π²ΠΈΡΡΡΠ°Π»ΡΠ½ΡΡ
ΡΡΡΡΠΊΡΡΡ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ², ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠΎΠΊΡΠ°ΡΠΈΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π° ΠΊΠ²Π°Π½ΡΠΎΠ²ΠΎ-ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ°ΡΡΠ΅Ρ. ΠΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π°Π½Π°Π»ΠΈΠ·Π° in silico ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΠΠ ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
Π΅Π³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΡΡ Ρ Π¦ΠΠ-2 Π² ΡΠΈΠΊΠ»ΠΎΠΎΠΊΡΠΈΠ³Π΅Π½Π°Π·Π½ΠΎΠΌ ΡΠ°ΠΉΡΠ΅, ΠΎΠ±ΡΠ°Π·ΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π½ΡΠ΅ ΡΠ²ΡΠ·ΠΈ Ρ SER353, SER530 ΠΈ ARG513. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Ρ
ΠΎΠ΄Π΅ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ Ξ±-Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΈΠ³ΡΠ°ΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΎΠ»Ρ ΠΏΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΠΠ ΠΈ Π΅Π³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² Ρ Π¦ΠΠ-2. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΠΠ.
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