Milestones chemical technology institute: our past and present

The article is devoted to the 95th anniversary of the Chemical technological Institute (CTI) of the Ural Federal University named after the first President of Russia B. N. Yeltsin (UrFU), which will be held in October 2015. Over the years Chemical technological Institute (CTI) has undergone many structure transformations in accordance with the tasks which were set before it the time and the development of our country. Currently this is a fairly large educational and research Institute, which employs more than 100 lecturers including more than 70 associate professors – candidates (PhD), 30 professors – doctors of Sciences (Hb), 3 academics and 1 corresponding member of RAS, trained more than 850 students

Commodity and Financial Networks in Regional Economics

The article discusses the relationship between commodity-production and financial network structures in the regional economy as dual conjugate systems. Material flows (raw materials, goods and so on) circulate in the commodity network as shown by Leontiev’s input-output balance model. Nonmaterial flows of property rights, money, and so on circulate in the financial network and reflect the movement of material objects in commodity networks. A network structure comprises closed and open circuits, which have fundamentally different characteristics: locally closed circuits meet local demand by supplying locally produced goods, thus ensuring self-reproduction of the local economy; open (or transit) circuits provide export-import flows. The article describes the mechanism of ‘internal’ money generation in closed circuits of commodity-production networks. The results of the theoretical study are illustrated by the calculations of closed and open circuit flows in the municipal economy model. Mutual settlements between the population and manufacturing enterprises are given in matrix form. It was found that the volume of the turnover in closed circuits of the municipal economic network model is about 28.5 % of the total turnover and can be provided by ‘internal’ non-inflationary money. The remaining 71.5 % of the total turnover correspond to the flows in the network’s open circuits providing export and import. The conclusion is made that in the innovation-driven economy, main attention should be given to the projects oriented towards domestic consumption rather than export supplies. The economy is based on internal production cycles in closed circuits. Thus, it is necessary to find the chains in the inter-industrial and inter-production relations which could become the basis of the production cycle. Money investments will complete such commodity chains and ‘launch’ the production cycle.The work has been prepared with the supprot of the Ural Federal University within the UrFU Program for the winners of the competition “Young Scientists of UrFU” No. 2.1.1.1-14/43

Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages

BACKGROUND: Macrophages are important cells of the innate immune system and contribute to a variety of physiological and pathophysiological responses. Monovalent and divalent ion channels have been studied in macrophage function, and while much research is still required, a role for these channels is beginning to emerge in macrophages. In addition to the plasma membrane, ion channels are also found in intracellular membranes including mitochondrial, lysosomal and nuclear membranes. While studying the function of plasma membrane located large conductance voltage- and calcium-activated potassium channels (BK channels) in a macrophage cell line RAW264.7, we became aware of the expression of these ion channels in other cellular locations. METHODS: Immunofluorescence and Western blot analysis were used to identify the expression of BK channels. To demonstrate a functional role for the nuclear located channel, we investigated the effect of the lipid soluble BK channel inhibitor paxilline on CREB phosphorylation. RESULTS: Treatment of resting macrophages with paxilline resulted in increased CREB phosphorylation. To confirm a role for nuclear BK channels, these experiments were repeated in isolated nuclei and similar results were found. Ca2+ and calmodulin-dependent kinases (CaMK) have been demonstrated to regulate CREB phosphorylation. Inhibition of CaMKII and CaMKIV resulted in the reversal of paxilline-induced CREB phosphorylation. CONCLUSIONS: These results suggest that nuclear BK channels regulate CREB phosphorylation in macrophages. Nuclear located ion channels may therefore be part of novel signalling pathways in macrophages and should be taken into account when studying the role of ion channels in these and other cells

The Notion of Subjective and Objective Modality in Language

The purpose of this article consists in giving a general notion of the categories of subjective and objective modality in language. The author notices and summarizes the most important theoretical approaches to the problem of objectivity and subjectivity in russian and foreign linguistic

Innovation-Driven Evolution of the Sharing Economy in a Russian Region: The Case of Sverdlovsk Region

Relevance. The sharing economy, an emerging sector, encounters obstacles such as intricate regulations, insufficient funding, constraints in data collection infrastructure, and uncertainties in evaluation methodologies. For the best results, it is crucial to thoroughly examine risks and find effective ways for the sharing economy to grow in the region.Research objective. This study aims to examine trends in sharing economy development in a major Russian area, using the case of Sverdlovsk region as an example.Data and Methods. The study relies on scientific publications from Scopus, EBSCO, and RSCI databases, alongside proprietary indicators and websites of 19 representative companies. It introduces a methodology utilizing SimilarWeb and Yandex WordStat services to collect consumer behavior metrics from online sharing economy platforms in Russia and Sverdlovsk region.Results. Results reveal escalating interest in sharing economy transportation services, suggesting potential funding reallocations in the public sector. Additionally, the popularity of freelance exchanges in Sverdlovsk region indicates a substantial remote work talent pool. Although the labor market's sharing economy is in its nascent stage, it demonstrates future growth potential. Notably, the rental of goods and equipment holds considerable promise for growth in Russia's industrial regions.Conclusion. The study identifies a research challenge centered on the formulation of methodological principles for evaluating essential parameters within innovative sharing economy economic models at the regional level. Methodological guidelines are outlined, encompassing empirical assessments via SimilarWeb and Yandex WordStat services, with proposed indicators for analysis. Recommendations to support shared economy companies are also provided, serving as a potential blueprint for the government of Sverdlovsk region in their future planning endeavors

Relevance of application of irradiated starter cultures to production of fermented milk products

Nowadays yogurt, fermented milk products, enriched with biologically active substances, acquire increasingly important significance in people's diets. The traditional method for producing fermented milk products and yogurt is to ferment the milk using starter cultures. The purpose of this research was to figure out if it is possible to use suspensions of probiotic microbial cultures irradiated with ionizing radiation to produce yoghurt products. Liquid live suspensions of bifidobacteria and lactobacilli, as well as a mixture of bifidobacteria, lactobacilli, propionibacteria and lactic acid streptococci were taken as a research model. The goal was achieved by receiving the yoghurt products enriched with active secondary metabolites due to using the suspensions of lysed cells of different microorganisms. We studied physico-chemical and organoleptic properties of the received products after 1, 7 and 14 days of storage

The influence of the industrial complex on the atmospheric air in the Sverdlovsk region

The work is dedicated to studying the level dynamics of polluting substances emissions into the atmosphere of Yekaterinburg city and the Sverdlovsk region in the period of 2012-2016. In the process of our work we found out an insignificant reduction of main indicators values such as SI, HR, and IPA to estimate the atmospheric air quality. Nevertheless, the level of the air pollution in Yekaterinburg city remained high in the stated period. We also suggested some methods to reduce enterprises emissions in the article, which will lead to improving the air quality. In the result of our work it was established that the main pollutants are suspended particles, nitrogen dioxides, phenol, and benzene. Moreover, the connection between the atmospheric air pollution degree and the Sverdlovsk region population's health was determined. © 2018 Institute of Physics Publishing. All rights reserved

Documented procedure «Control of nonconforming product» in anticipation of the re-certification of the management system of the organization

Ресертификация система менеджмента организации на соответствие требованиям ГОСТ Р ИСО 9001:2015 обязывает обновлять и актуализировать документацию СМК для результативного и эффективного прохождения как внутреннего, так и внешнего аудитаRecertification of the organization's management system for compliance with GOST R ISO 9001:2015 requires to update or keep current the documentation of the QMS for efficient and ef-fective flow of both internal and external audi

Pseudobinary Fe4Ti3S8 compound with a NiAs-type structure: Effect of Ti for Fe substitution

The transition metal sulfide Fe4Ti3S8 with 7:8 composition has been synthesized and studied by using X-ray diffraction, magnetization and electrical resistivity measurements. This compound exhibits a monoclinic crystal lattice (space group I12/m1). The substitution of Ti for Fe in Fe7S8 is found to result in a lowering of the Curie temperature (TC ≈ 205 K), in a larger value of the coercive field (Hc ∼ 9 kOe at low temperatures) and in a substantial growth of the resultant magnetic moment per formula unit (μFU) in comparison with Fe7S8. An enhanced value of μFU is attributed to the preferential substitution of Ti in alternating cation layers. From the paramagnetic susceptibility measured within temperature interval (250-350) K, a reduced value of the effective moment per iron (μFe ∼ 2.4μB) was determined. The electrical resistivity of Fe4Ti3S8 shows a non-metallic behavior and is affected by magnetic ordering. © 2013 Elsevier Masson SAS. All rights reserved