60 research outputs found

    A Comparison of Ignition Characteristics of Diesel Fuels as Determined in Engines and in a Constant-volume Bomb

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    Ignition-lag data have been obtained for seven fuels injected into heated, compressed air under conditions simulating those in a compression-ignition engine. The results of the bomb tests have been compared with similar engine data, and the differences between the two sets of results are explained in terms of the response of each fuel to variations in air density and temperature

    Auto-Ignition and Combustion of Diesel Fuel in a Constant-Volume Bomb

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    Report presents the results of a study of variations in ignition lag and combustion associated with changes in air temperature and density for a diesel fuel in a constant-volume bomb. The test results have been discussed in terms of engine performance wherever comparisons could be drawn. The most important conclusions drawn from this investigation are: the ignition lag was essentially independent of the injected fuel quantity. Extrapolation of the curves for the fuel used shows that the lag could not be greatly decreased by exceeding the compression-ignition engines. In order to obtain the best combustion and thermal efficiency, it was desirable to use the longest ignition lag consistent with a permissible rate of pressure rise

    Heat Transfer to Fuel Sprays Injected into Heated Gases

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    This report presents the results of a study made of the influence of several variables on the pressure decrease accompanying injection of a relatively cool liquid into a heated compressed gas. Indirectly, this pressure decrease and the time rate of change of it are indicative of the total heat transferred as well as the rate of heat transfer between the gas and the injected liquid. Air, nitrogen, and carbon dioxide were used as ambient gases; diesel fuel and benzene were the injected liquids. The gas densities and gas-fuel ratios covered approximately the range used in compression-ignition engines. The gas temperatures ranged from 150 degrees c. to 350 degrees c

    Identification of common cystic fibrosis mutations in African-Americans with cystic fibrosis increases the detection rate to 75%.

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    Cystic fibrosis (CF)--an autosomal recessive disorder caused by mutations in CF transmembrane conductance regulator (CFTR) and characterized by abnormal chloride conduction across epithelial membranes, leading to chronic lung and exocrine pancreatic disease--is less common in African-Americans than in Caucasians. No large-scale studies of mutation identification and screening in African-American CF patients have been reported, to date. In this study, the entire coding and flanking intronic sequence of the CFTR gene was analyzed by denaturing gradient-gel electrophoresis and sequencing in an index group of 82 African-American CF chromosomes to identify mutations. One novel mutation, 3120+1G-->A, occurred with a frequency of 12.3% and was also detected in a native African patient. To establish frequencies, an additional group of 66 African-American CF chromosomes were screened for mutations identified in two or more African-American patients. Screening for 16 "common Caucasian" mutations identified 52% of CF alleles in African-Americans, while screening for 8 "common African" mutations accounted for an additional 23%. The combined detection rate of 75% was comparable to the sensitivity of mutation analysis in Caucasian CF patients. These results indicate that African-Americans have their own set of "common" CF mutations that originate from the native African population. Inclusion of these "common" mutations substantially improves CF mutation detection rates in African-Americans
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