Studies on the Accumulation of Chromium in Fenugreek

Studying Cr uptake by Fenugreek, we note that the maximum concentration of Cr takes place in the shells of the pods followed by leaves, stems and seeds in that order. Interestingly, applied higher doses of Cr does not increase accumulation of Cr in the stems, rather Cr content in the stems levels off. However, the maximum dispersal/distribution of Cr taken up is in the leaves

Axigluons cannot explain the observed top quark forward-backward asymmetry

We study an SU(3)^2 axigluon model introduced by Frampton, Shu, and Wang to explain the recent Fermilab Tevatron observation of a significant positive enhancement in the top quark forward-backward asymmetry relative to standard model predictions. First, we demonstrate that data on neutral B_d-meson mixing excludes the region of model parameter space where the top asymmetry is predicted to be the largest. Keeping the gauge couplings below the critical value that would lead to fermion condensation imposes further limits at large axigluon mass, while precision electroweak constraints on the model are relatively mild. Furthermore, by considering an extension to an SU(3)^3 color group, we demonstrate that embedding the model in an extra-dimensional framework can only dilute the axigluon effect on the forward-backward asymmetry. We conclude that axigluon models are unlikely to be the source of the observed top quark asymmetry.Comment: 12 pages, 7 eps figures included. Minor changes to conform with published versio

Chromium uptake by Fenugreek

Fenugreek (Trigonella foenum- graecum) is both herb (leaves) and a spice (seed) belonging to the family Fabaceae. Fenugreek leaves and seeds are used in the cuisine of India. Fenugreek also has medicinal value. Fenugreek seeds are known to reduce serum glucose and improve glucose tolerance and hence are prescribed to diabetic patients. In the recent past supplemental Chromium is being prescribed to diabetic patients to activate (increased- insulin binding, insulin receptor number, insulin receptor phosphorylation) insulin. Plants can uptake substantial quantities of toxic metals from contaminated soils if these soils are well ameliorated. 

It is then probable that the medicinal efficacy of Fenugreek in the case of diabetes could be enhanced if it takes up chromium from the soil. Preliminary studies are being conducted to note the chromium uptake by Fenugreek from soils which are applied with potassium dichromate

Quantum phase transition in a Dp-Dq system

Using the top-down approach, we study intersecting Dp-Dq brane configuration in string theory and find examples, where there can be a quantum phase transition at zero temperature induced by the violation of the Breitenlohner-Freedman (BF) bound at IR, which is done essentially by a combination of charge density and magnetic fields. In particular, there exists a Berezinskii-Kosterlitz-Thouless (BKT) type of transition for D3-D5 and D5-D5 systems. The study of the BKT type of transition is initiated by Jensen et al. [Phys. Rev. Lett. {\bf 105}, 041601 (2010) ] for a D3-D5 system with nonzero charge density and a magnetic field. Here, we show that one can have the BKT transition for a D3-D5 system even in the absence of charge density but requires multiple magnetic fields. In this case the field theory lives in 2+1 dimensions, whereas for the D5-D5 type, the transition requires the presence of both the charge density and magnetic fields and the dual field theory lives on a 3+1 dimensional spacetime. We also study the D3-D7 system but it does not show the BKT type of transition.Comment: 1+37 pages; v2 Chern-Simon term for D3-D5 case presented, typos fixed and a reference added; v3 Minor corrections, Chern-Simon term for D2-D4, D4-D6, and D5-D7 added, also an appendix and few references added; v4 Journal versio

Comparative study of scoring systems in ICU and emergency department in predicting mortality of critically ill

Background: Scoring systems can be used to define critically ill patients, estimate their prognosis, help in clinical decision making, and guide the allocation of resources and to estimate the quality of care.  It remains unclear whether the additional data needed to compute ICU scores improves mortality prediction for critically ill patients compared to the simpler ED scores.Methods: We have done a prospective observational study of consecutively admitted 400 critically ill patients to ICU directly from Emergency Department in Dr PSIMS and RF over a period of 2 years. Clinical and laboratory data conforming to the modified early warning score (MEWS), rapid emergency medicine score (REMS), acute physiology and chronic health evaluation (APACHE II), and simplified acute physiology score (SAPS II) were recorded for all patients. A comparison was made between ED scoring systems MEWS, REMS and ICU scoring systems APACHE II, SAPSII. The outcome was recorded in two categories: survived and non-survived with a primary end point of 30-day mortality. Discrimination was evaluated using receiver operating characteristic (ROC) curves.Results: The ICU scores outperformed the ED scores with more area under curve values. The predicted mortality percentage of ICU based scoring systems is high compared to emergency scores (predicted mortality % of SAPS II-63%, APACHE II-33.3%, MEWS-18.5%, REMS-14.8%).Conclusions: ICU scores showed more predictive accuracy than ED scores in prognosticating the outcomes in critically ill patients. This difference is seemed more due to complexity of ICU scores

Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines

A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines. [Refer to PDF for graphical abstract

A Hybrid Particle Swarm Optimization Approach for Solving Optimal Power Flow With Thyristor Controlled Series Capacitor

ABSTRACT: This paper presents an application of Hybrid Particle Swarm Optimization (HPSO) to obtain the optimal settings of control variables. The HPSO technique is used to find the Optimal Power Flow (OPF) problem solution for minimization of fuel cost as objective function. The suitability of this approach is examined on the standard IEEE 14 bus test system with TCSC. Simulation results shows that the HPSO algorithm with TCSC gives better solution to enhance the system performance

Role of soluble, cell wall bound phenolics, tannin and flavonoid contents in maize resistance to pink stem borer Sesamia inferens Walker

The pink stem borer Sesamia inferens Walker is an important pest of winter maize which causes significant yieldlosses. In an attempt to identify the biochemical basis of resistance against S. inferens, total soluble phenolics, boundphenolics, cell wall-bound hydroxycinnamic acids-p-coumaric acid (p-CA), ferulic acid (FA), total tannin contentand total flavonoid contents, were measured in leaf at 10, 20 days after germination (DAG); stem at 20, 40 DAG;pith and rind tissues at 60 DAG (stem differentiated). From the present study, it was found that bound phenolics,p-CA, ferulic acid and total tannin contents contribute to the maize defense mechanism against S. inferens. Totalbound phenolic content showed negative correlation with Leaf Injury Rating (LIR). Highly significant strong positivecorrelation (+0.9750) was observed between LIR and total soluble phenolics in leaf tissue at 20 DAG. Similarlyhighly significant strong positive correlation between LIR and total tannins (+0.9354**) and flavonoids (+0.9582**)in pith at 60 DAG was observed. Further, a strong significant positive correlation was also observed between LIRand p-CA (+0.9199*) in pith at 60 DAG and total ferulic acid (+0.9051*) in rind at 60 DAG. The significant strong negativecorrelation between LIR and p-CA (-0.8441*) in stem at 40 DAG was observed. The total bound phenolicsin rind at 60 DAG (0.756), in leaf at 20 DAG (0.681), and total soluble phenolics in the stem at 20 DAG (0.685) showedhigher loadings with PC1, PC2, and PC3, respectively. Genotype-by-biochemical factor biplot showed that thedata of biochemical parameters measured in different tissues and stages could be able to group the genotypesaccording to their reaction to S. inferens