R^2 Corrections to Asymptotically Lifshitz Spacetimes

We study $R^{2}$ corrections to five-dimensional asymptotically Lifshitz spacetimes by adding Gauss-Bonnet terms in the effective action. For the zero-temperature backgrounds we obtain exact solutions in both pure Gauss-Bonnet gravity and Gauss-Bonnet gravity with non-trivial matter. The dynamical exponent undergoes finite renormalization in the latter case. For the finite-temperature backgrounds we obtain black brane solutions perturbatively and calculate the ratio of shear viscosity to entropy density $\eta/s$. The KSS bound is still violated but unlike the relativistic counterparts, the causality of the boundary field theory cannot be taken as a constraint.Comment: 24 pages, Latex, typos fixed, accepted by JHE

Non-relativistic CFT and Semi-classical Strings

We study different features of 3D non-relativistic CFT using gravity description. As the corresponding gravity solution can be embedded into the type IIB string theory, we study semi-classical closed/open strings in this background. In particular we consider folded rotating and circular pulsating closed strings where we find the anomalous dimension of the dual operators as a function of their quantum numbers. We also consider moving open strings in this background which can be used to compute the drag force. In particular we find that for slowly moving particles, the energy is lost exponentially and the characteristic time is given in terms of the temperature, while for fast moving particles the energy loss goes as inverse of the time and the characteristic time is independent of the temperature.Comment: 20 pages, Latex file; V2: typos corrected, ref. adde

Some No-go Theorems for String Duals of Non-relativistic Lifshitz-like Theories

We study possibilities of string theory embeddings of the gravity duals for non-relativistic Lifshitz-like theories with anisotropic scale invariance. We search classical solutions in type IIA and eleven-dimensional supergravities which are expected to be dual to (2+1)-dimensional Lifshitz-like theories. Under reasonable ansaetze, we prove that such gravity duals in the supergravities are not possible. We also discuss a possible physical reason behind this.Comment: 18 pages, Latex, flux conditions clarified (v2), brief summary of results added (v3

Higgsless Electroweak Symmetry Breaking in Warped Backgrounds: Constraints and Signatures

We examine the phenomenology of a warped 5-dimensional model based on SU(2)$_L \times$ SU(2)$_R \times$ U(1)$_{B-L}$ model which implements electroweak symmetry breaking through boundary conditions, without the presence of a Higgs boson. We use precision electroweak data to constrain the general parameter space of this model. Our analysis includes independent $L$ and $R$ gauge couplings, radiatively induced UV boundary gauge kinetic terms, and all higher order corrections from the curvature of the 5-d space. We show that this setup can be brought into good agreement with the precision electroweak data for typical values of the parameters. However, we find that the entire range of model parameters leads to violation of perturbative unitarity in gauge boson scattering and hence this model is not a reliable perturbative framework. Assuming that unitarity can be restored in a modified version of this scenario, we consider the collider signatures. It is found that new spin-1 states will be observed at the LHC and measurement of their properties would identify this model. However, the spin-2 graviton Kaluza-Klein resonances, which are a hallmark of the Randall-Sundrum model, are too weakly coupled to be detected.Comment: More detailed analysis, added references, 43 pages, 15 figures, LaTe

The Effective Use of Precision Electroweak Measurements

Several reasonably model-independent formulations of the implications of new physics for precision electroweak measurements have been developed over the past years, most notably by Peskin and Takeuchi, and by Altarelli \etal. These formulations work by identifying a small, but useful, set of parameters through which new physics often enters into well-measured physical observables. For the theories to which such an analysis applies, this approach greatly streamlines the confrontation with the data. Since the experimentally-allowed range for these parameters has been determined from global fits to the data, theorists need only compute their predictions for these parameters to constrain their models. These methods are summarized here, together with several recent generalizations which permit applications to wider classes of new physics, and which include the original approaches as special cases.Comment: 29 pages, latex, 3 figures available on reques

Deformations of Holographic Duals to Non-Relativistic CFTs

We construct the non-relativistic counterparts of some well-known supergravity solutions dual to relevant and marginal deformations of N=4 super Yang-Mills. The main tool we use is the null Melvin twist and we apply it to the N=1 and N=2* Pilch-Warner RG flow solutions as well as the Lunin-Maldacena solution dual to beta-deformations of N=4 super Yang-Mills. We also obtain a family of supergravity solutions with Schrodinger symmetry interpolating between the non-relativistic version of the N=1 Pilch-Warner and Klebanov-Witten fixed points. A generic feature of these non-relativistic backgrounds is the presence of non-vanishing internal fluxes. We also find the most general, three-parameter, null Melvin twist of the AdS_5xS^5 black hole. We briefly comment on the field theories dual to these supergravity solutions.Comment: 34 pages, 1 figure, LaTe

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy