Instability of a supersonic shock free elliptic jet

This paper presents a comparison of the measured and the computed spatial stability properties of an aspect ratio 2 supersonic shock free elliptic jet. The shock free nature of the elliptic jet provides an ideal test of validity of modeling the large scale coherent structures in the initial mixing region of noncircular supersonic jets with linear hydrodynamic stability theory. Both aerodynamic and acoustic data were measured. The data are used to compute the mean velocity profiles and to provide a description of the spatial composition of pressure waves in the elliptic jet. A hybrid numerical scheme is applied to solve the Rayleigh problem governing the inviscid linear spatial stability of the jet. The measured mean velocity profiles are used to provide a qualitative model for the cross sectional geometry and the smooth velocity profiles used in the stability analysis. Computational results are presented for several modes of instability at two jet cross sections. The acoustic measurements show that a varicose instability is the jet's perferred mode of motion. The stability analysis predicts that the Strouhal number varies linearly as a function of axial distance in the jet's initial mixing region, which is in good qualitative agreement with previous measurements

Noise reduction evaluation of grids in a supersonic air stream with application to Space Shuttle

Near field acoustic measurements were obtained for a model supersonic air jet perturbed by a screen. Noise reduction potential in the vicinity of the space shuttle vehicle during ground launch when the rocket exhaust flow is perturbed by a grid was determined. Both 10 and 12 mesh screens were utilized for this experiment, and each exhibited a noise reduction only at very low frequencies in the near field forward arc. A power spectrum analysis revealed that a modest reduction of from 3 to 5 decibels exists below a Strouhal number S sub t = 0.11. Above S sub t = 0.11 screen harmonics increased the observed sound pressure level. The favorable noise reductions obtained with screens for S sub t 0.11 may be of substantial interest for the space shuttle at ground launch

Shock-free supersonic elliptic nozzles and method of forming same

A method of forming a shock-free supersonic elliptic nozzle, in which the nozzle to be designed is divided into three sections, a circular-to-elliptic section which begins at a circular nozzle inlet, an elliptic subsonic section downstream from the circular-to-elliptic section, and a supersonic section downstream from the elliptic subsonic section is described. The maximum and minimum radii for each axial point in the circular-to-elliptic section and the elliptic subsonic section are then separately determined, the maximum and minimum radii being the radii for the widest part of an elliptic cross-section and the narrowest part of the elliptic cross-section, respectively. The maximum and minimum radii for each axial point in the supersonic section are determined based on the Method of Characteristics. Then, each of the three sections are based on the maximum and minimum radii for each axial point in the section. The resulting nozzle is acoustically superior

Nonlinear Stability of Supersonic Jets

This paper presents stability calculations made for a shock-free supersonic jet using the model based on parabolized stability equations. In this analysis the large-scale structures, which play a dominant role in the mixing as well as the noise radiated, are modeled as instability waves. This model takes into consideration non-parallel flow effects and also nonlinear interaction of the instability waves. The stability calculations have been performed for different frequencies and mode numbers over a range of jet operating temperatures. Comparisons are made, where appropriate, with the solutions to Rayleigh's equation (linear, inviscid analysis with the assumption of parallel flow). The comparison of the solutions obtained using the two approaches show very good agreement

Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein

Human cells are exposed to the electrophilic [alpha],[beta]-unsaturated aldehyde acrolein from a variety of sources. The reaction of acrolein with functionally critical protein thiol residues can yield important biological consequences. Protein tyrosine phosphatases (PTPs) are an important class of cysteine-dependent enzymes whose reactivity with acrolein previously has not been well-characterized. These enzymes catalyze the dephosphorylation of phosphotyrosine residues on proteins via a phosphocysteine intermediate. PTPs work in tandem with protein tyrosine kinases to regulate a number of critically important mammalian signal transduction pathways. We find that acrolein is a potent time-dependent inactivator of the enzyme PTP1B (kinact = 0.02 [plus or minus] 0.005 s-1 and KI = 2.3 [plus or minus] 0.6 x 10-4 M). The enzyme activity does not return upon gel filtration of the inactivated enzyme, and addition of the competitive phosphatase inhibitor vanadate slows inactivation of PTP1B by acrolein. Together, these observations suggest that acrolein covalently modifies the active site of PTP1B. Mass spectrometric analysis reveals that acrolein modifies the catalytic cysteine residue at the active site of the enzyme. Aliphatic aldehydes such as glyoxal, acetaldehyde, and propanal are relatively weak inactivators of PTP1B under the conditions employed here. Similarly, unsaturated aldehydes such as crotonaldehyde and 3-methyl-2-butenal bearing substitution at the alkene terminus are poor inactivators of the enzyme. Overall, the data suggest that enzyme inactivation occurs via conjugate addition of the catalytic cysteine residue to the carbon-carbon double bond of acrolein. The results indicate that inactivation of PTPs should be considered as a possible contributor to the diverse biological activities of acrolein and structurally related α,β-unsaturated aldehydes

Electroconvulsive therapy added to non-clozapine antipsychotic medication for treatment resistant schizophrenia: Meta-analysis of randomized controlled trials

This meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of the combination of electroconvulsive therapy (ECT) and antipsychotic medication (except for clozapine) versus the same antipsychotic monotherapy for treatment-resistant schizophrenia (TRS). Two independent investigators extracted data for a random effects meta-analysis and pre-specified subgroup and meta-regression analyses. Weighted and standard mean difference (WMD/SMD), risk ratio (RR) ±95% confidence intervals (CIs), number needed to treat (NNT), and number needed to harm (NNH) were calculated. Eleven studies (n = 818, duration = 10.2±5.5 weeks) were identified for meta-analysis. Adjunctive ECT was superior to antipsychotic monotherapy regarding (1) symptomatic improvement at last-observation endpoint with an SMD of -0.67 (

Electroconvulsive Therapy Practice Changes in Older Individuals Due to COVID-19: Expert Consensus Statement

© 2020 American Association for Geriatric Psychiatry The ubiquitous coronavirus 2019 (COVID-19) pandemic has required healthcare providers across all disciplines to rapidly adapt to public health guidelines to reduce risk while maintaining quality of care. Electroconvulsive therapy (ECT), which involves an aerosol-generating procedure from manual ventilation with a bag mask valve while under anesthesia, has undergone drastic practice changes in order to minimize disruption of treatment in the midst of COVID-19. In this paper, we provide a consensus statement on the clinical practice changes in ECT specific to older adults based on expert group discussions of ECT practitioners across the country and a systematic review of the literature. There is a universal consensus that ECT is an essential treatment of severe mental illness. In addition, there is a clear consensus on what modifications are imperative to ensure continued delivery of ECT in a manner that is safe for patients and Northwell Health, while maintaining the viability of ECT services. Approaches to modifications in ECT to address infection control, altered ECT procedures, and adjusting ECT operations are almost uniform across the globe. With modified ECT procedures, it is possible to continue to meet the needs of older patients while mitigating risk of transmission to this vulnerable population

PAB3D: Its History in the Use of Turbulence Models in the Simulation of Jet and Nozzle Flows

This is a review paper for PAB3D s history in the implementation of turbulence models for simulating jet and nozzle flows. We describe different turbulence models used in the simulation of subsonic and supersonic jet and nozzle flows. The time-averaged simulations use modified linear or nonlinear two-equation models to account for supersonic flow as well as high temperature mixing. Two multiscale-type turbulence models are used for unsteady flow simulations. These models require modifications to the Reynolds Averaged Navier-Stokes (RANS) equations. The first scheme is a hybrid RANS/LES model utilizing the two-equation (k-epsilon) model with a RANS/LES transition function, dependent on grid spacing and the computed turbulence length scale. The second scheme is a modified version of the partially averaged Navier-Stokes (PANS) formulation. All of these models are implemented in the three-dimensional Navier-Stokes code PAB3D. This paper discusses computational methods, code implementation, computed results for a wide range of nozzle configurations at various operating conditions, and comparisons with available experimental data. Very good agreement is shown between the numerical solutions and available experimental data over a wide range of operating conditions

Status of Turbulence Modeling for Hypersonic Propulsion Flowpaths

This report provides an assessment of current turbulent flow calculation methods for hypersonic propulsion flowpaths, particularly the scramjet engine. Emphasis is placed on Reynolds-averaged Navier-Stokes (RANS) methods, but some discussion of newer meth- ods such as Large Eddy Simulation (LES) is also provided. The report is organized by considering technical issues throughout the scramjet-powered vehicle flowpath including laminar-to-turbulent boundary layer transition, shock wave / turbulent boundary layer interactions, scalar transport modeling (specifically the significance of turbulent Prandtl and Schmidt numbers) and compressible mixing. Unit problems are primarily used to conduct the assessment. In the combustor, results from calculations of a direct connect supersonic combustion experiment are also used to address the effects of turbulence model selection and in particular settings for the turbulent Prandtl and Schmidt numbers. It is concluded that RANS turbulence modeling shortfalls are still a major limitation to the accuracy of hypersonic propulsion simulations, whether considering individual components or an overall system. Newer methods such as LES-based techniques may be promising, but are not yet at a maturity to be used routinely by the hypersonic propulsion community. The need for fundamental experiments to provide data for turbulence model development and validation is discussed