903 research outputs found
Mobilisasi Massa melalui Tajen dalam Pemilihan Umum Legislatif Tahun 2014 di Kabupaten Tabanan
Tajen is a form of gambling in Bali, and is a social pathology that can destructive people's live. However, the tajen remains a popular and become a political commodity. The current era of decentralization, created political elites in regions with social capital owned, compete and mobilize all of social capital in society for power and resources in the region through legislative elections. Mobilization through the existing tajen groups in Tabanan carried out by local political elites to win on the legislative elections in 2014. The purpose of this research was to determine, how the tajen as a social pathology was used to mobilize the masses in the 2014 Legislative Election at Tabanan Regency. The research used qualitative method with descriptive research type of analysis. Primary data was collected through interview technique purposive sampling and snowball sampling, and secondary data obtained from news, articles on internet and related books of the research. This research uses Putnam's social capital theory. The results of this research indicate ; First, mass mobilization by the legislative candidate through sekaa tajen in the electoral area of Tabanan 2, conducted by directed families of sekaa tajen, and directed the people of the village that becomes the arena of tajen, to choose candidate that carried by the sekaa tajen. This is due to social capital and high socio-economic status of legislative candidate, legislative candidate promises the protection to the sekaa tajen, in order that tajen to safe. second, There is a public dilemma of tajen, where in one side the tajen is considered as a culture that has been passed down from generation to generation, and on the other hand according to law KUHP article 303 Tajen is a criminal offense.
Keywords: Tajen, Mass Mobilization, Local Political Elite, Social Capital, Decentralizatio
Coarse graining of master equations with fast and slow states
We propose a general method for simplifying master equations by eliminating
from the description rapidly evolving states. The physical recipe we impose is
the suppression of these states and a renormalization of the rates of all the
surviving states. In some cases, this decimation procedure can be analytically
carried out and is consistent with other analytical approaches, like in the
problem of the random walk in a double-well potential. We discuss the
application of our method to nontrivial examples: diffusion in a lattice with
defects and a model of an enzymatic reaction outside the steady state regime.Comment: 9 pages, 9 figures, final version (new subsection and many minor
improvements
Rigorous elimination of fast stochastic variables from the linear noise approximation using projection operators
The linear noise approximation (LNA) offers a simple means by which one can
study intrinsic noise in monostable biochemical networks. Using simple physical
arguments, we have recently introduced the slow-scale LNA (ssLNA) which is a
reduced version of the LNA under conditions of timescale separation. In this
paper, we present the first rigorous derivation of the ssLNA using the
projection operator technique and show that the ssLNA follows uniquely from the
standard LNA under the same conditions of timescale separation as those
required for the deterministic quasi-steady state approximation. We also show
that the large molecule number limit of several common stochastic model
reduction techniques under timescale separation conditions constitutes a
special case of the ssLNA.Comment: 10 pages, 1 figure, submitted to Physical Review E; see also BMC
Systems Biology 6, 39 (2012
Generalized Haldane Equation and Fluctuation Theorem in the Steady State Cycle Kinetics of Single Enzymes
Enyzme kinetics are cyclic. We study a Markov renewal process model of
single-enzyme turnover in nonequilibrium steady-state (NESS) with sustained
concentrations for substrates and products. We show that the forward and
backward cycle times have idential non-exponential distributions:
\QQ_+(t)=\QQ_-(t). This equation generalizes the Haldane relation in
reversible enzyme kinetics. In terms of the probabilities for the forward
() and backward () cycles, is shown to be the
chemical driving force of the NESS, . More interestingly, the moment
generating function of the stochastic number of substrate cycle ,
follows the fluctuation theorem in the form of
Kurchan-Lebowitz-Spohn-type symmetry. When $\lambda$ = $\Delta\mu/k_BT$, we
obtain the Jarzynski-Hatano-Sasa-type equality:
1 for all , where is the fluctuating chemical work
done for sustaining the NESS. This theory suggests possible methods to
experimentally determine the nonequilibrium driving force {\it in situ} from
turnover data via single-molecule enzymology.Comment: 4 pages, 3 figure
Shear induced grain boundary motion for lamellar phases in the weakly nonlinear regime
We study the effect of an externally imposed oscillatory shear on the motion
of a grain boundary that separates differently oriented domains of the lamellar
phase of a diblock copolymer. A direct numerical solution of the
Swift-Hohenberg equation in shear flow is used for the case of a
transverse/parallel grain boundary in the limits of weak nonlinearity and low
shear frequency. We focus on the region of parameters in which both transverse
and parallel lamellae are linearly stable. Shearing leads to excess free energy
in the transverse region relative to the parallel region, which is in turn
dissipated by net motion of the boundary toward the transverse region. The
observed boundary motion is a combination of rigid advection by the flow and
order parameter diffusion. The latter includes break up and reconnection of
lamellae, as well as a weak Eckhaus instability in the boundary region for
sufficiently large strain amplitude that leads to slow wavenumber readjustment.
The net average velocity is seen to increase with frequency and strain
amplitude, and can be obtained by a multiple scale expansion of the governing
equations
Michaelis-Menten Relations for Complex Enzymatic Networks
All biological processes are controlled by complex systems of enzymatic
chemical reactions. Although the majority of enzymatic networks have very
elaborate structures, there are many experimental observations indicating that
some turnover rates still follow a simple Michaelis-Menten relation with a
hyperbolic dependence on a substrate concentration. The original
Michaelis-Menten mechanism has been derived as a steady-state approximation for
a single-pathway enzymatic chain. The validity of this mechanism for many
complex enzymatic systems is surprising. To determine general conditions when
this relation might be observed in experiments, enzymatic networks consisting
of coupled parallel pathways are investigated theoretically. It is found that
the Michaelis-Menten equation is satisfied for specific relations between
chemical rates, and it also corresponds to the situation with no fluxes between
parallel pathways. Our results are illustrated for simple models. The
importance of the Michaelis-Menten relationship and derived criteria for
single-molecule experimental studies of enzymatic processes are discussed.Comment: 10 pages, 4 figure
Dynamic balance of proâ and antiâinflammatory signals controls disease and limits pathology
Immune responses to pathogens are complex and not well understood in many diseases, and this is especially true for infections by persistent pathogens. One mechanism that allows for longâterm control of infection while also preventing an overâzealous inflammatory response from causing extensive tissue damage is for the immune system to balance proâ and antiâinflammatory cells and signals. This balance is dynamic and the immune system responds to cues from both host and pathogen, maintaining a steady state across multiple scales through continuous feedback. Identifying the signals, cells, cytokines, and other immune response factors that mediate this balance over time has been difficult using traditional research strategies. Computational modeling studies based on data from traditional systems can identify how this balance contributes to immunity. Here we provide evidence from both experimental and mathematical/computational studies to support the concept of a dynamic balance operating during persistent and other infection scenarios. We focus mainly on tuberculosis, currently the leading cause of death due to infectious disease in the world, and also provide evidence for other infections. A better understanding of the dynamically balanced immune response can help shape treatment strategies that utilize both drugs and hostâdirected therapies.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146448/1/imr12671.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146448/2/imr12671_am.pd
Blood coagulation dynamics: mathematical modeling and stability results
The hemostatic system is a highly complex multicomponent biosystem that under normal physiologic conditions maintains the fluidity of blood. Coagulation is initiated in response to endothelial surface vascular injury or certain biochemical stimuli, by the exposure of plasma to Tissue Factor (TF), that activates platelets and the coagulation cascade, inducing clot formation, growth and lysis. In recent years considerable advances have contributed to understand this highly complex process and some mathematical and numerical models have been developed. However, mathematical models that are both rigorous and comprehensive in terms of meaningful experimental data, are not available yet. In this paper a mathematical model of coagulation and fibrinolysis in flowing blood that integrates biochemical, physiologic and rheological factors, is revisited. Three-dimensional numerical simulations are performed in an idealized stenosed blood vessel where clot formation and growth are initialized through appropriate boundary conditions on a prescribed region of the vessel wall. Stability results are obtained for a simplified version of the clot model in quiescent plasma, involving some of the most relevant enzymatic reactions that follow Michaelis-Menten kinetics, and having a continuum of equilibria.CEMAT/IST through FCT [PTDC/MAT/68166/2006]; Czech Science Foundation [201/09/0917]; Grant Agency of the Academy of Sciences of the CR [IAA100190804]; Ministry of Education of Czech Republic [6840770010]info:eu-repo/semantics/publishedVersio
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Overview of mathematical approaches used to model bacterial chemotaxis II: bacterial populations
We review the application of mathematical modeling to understanding the behavior of populations of chemotactic bacteria. The application of continuum mathematical models, in particular generalized KellerâSegel models, is discussed along with attempts to incorporate the microscale (individual) behavior on the macroscale, modeling the interaction between different species of bacteria, the interaction of bacteria with their environment, and methods used to obtain experimentally verified parameter values. We allude briefly to the role of modeling pattern formation in understanding collective behavior within bacterial populations. Various aspects of each model are discussed and areas for possible future research are postulated
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