Song, Ritual, and Commemoration in Early Greek Poetry and Tragedy

Charles Segal's most recent books include Interpreting Greek Tragedy (1986), Pindar's Mythmaking (1986), Language and Desire in Seneca's Phaedra (1986), and Orpheus: The Myth of the Poet (1989). He is presently a Senior Fellow of the Center for Advanced Study in Behavioral Sciences for 1989-90, and will take an appointment as Professor of Greek and Latin at Harvard in 1990-91

Improving School Readiness Outcomes: Lessons From Six Communities

Describes efforts in California, Florida, Pennsylvania, South Carolina, and Virginia to develop early learning systems for school readiness, using federal and state resources. Includes common themes that emerged from these six case studies

Strategic Auditing in a Political Hierarchy: An Informational Model of the Supreme Court\u27s Certiorari Decisions

We examine how the Supreme Court uses signals and indices from lower courts to determine which cases to review. In our game theoretic model, a higher court cues from publicly observable case facts, the known preferences of a lower court and its derision. The lower court attempts to enforce its own preferences, exploiting ambiguity in cases\u27 fact patterns. In equilibrium, a conservative higher court declines to review conservative decisions from lower courts regardless of the facts of die case or the relative ideology of the judges. But a conservative higher court probabilistically reviews liberal decisions, with the audit rate tied to observable facts and the ideology of the lower court judge. We derive comparative static results and rest them with a random sample of search-and-seizure cases appealed to the Burger Court between 1972 and 1986. The evidence broadly supports the model

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

Distinct epigenomic profiles of histone marks have been associated with gene expression, but questions regarding the causal relationship remain. Here we investigated the activity of a broad collection of genomically targeted epigenetic regulators that could write epigenetic marks associated with a repressed chromatin state (G9A, SUV39H1, Krüppel-associated box (KRAB), DNMT3A as well as the first targetable versions of Ezh2 and Friend of GATA-1 (FOG1)). dCas9 fusions produced target gene repression over a range of 0- to 10-fold that varied by locus and cell type. dCpf1 fusions were unable to repress gene expression. The most persistent gene repression required the action of several effector domains; however, KRAB-dCas9 did not contribute to persistence in contrast to previous reports. A 'direct tethering' strategy attaching the Ezh2 methyltransferase enzyme to dCas9, as well as a 'recruitment' strategy attaching the N-terminal 45 residues of FOG1 to dCas9 to recruit the endogenous nucleosome remodeling and deacetylase complex, were both successful in targeted deposition of H3K27me3. Surprisingly, however, repression was not correlated with deposition of either H3K9me3 or H3K27me3. Our results suggest that so-called repressive histone modifications are not sufficient for gene repression. The easily programmable dCas9 toolkit allowed precise control of epigenetic information and dissection of the relationship between the epigenome and gene regulation

Hemodialysis Graft with Blind Loop Inflow Segment Treated with Stent Placement

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74924/1/j.1525-139X.2008.00460.x.pd

An Empirical Test of the Rational Actor Theory of Litigation

This article examines the decisions of litigants in criminal cases to appeal decisions from the U.S. Courts of Appeals to the U.S. Supreme Court. Using a random sample of search and seizure cases from 1962 through 1990 and a measure of the likelihood that the appeals court decision will be reversed if cert is granted, we demonstrate that litigants behave as if they rationally consider costs and benefits in their decisions to appeal. Given the extraordinary number of cases decided by lower federal courts vis-g-vis the number of cases the Supreme Court can decide, we argue that such behavior is necessary if the Supreme Court is to retain control over the federal judiciary

Simple, Defensible Sample Sizes Based on Cost Efficiency -- With Discussion and Rejoinder

The conventional approach of choosing sample size to provide 80% or greater power ignores the cost implications of different sample size choices. Costs, however, are often impossible for investigators and funders to ignore in actual practice. Here, we propose and justify a new approach for choosing sample size based on cost efficiency, the ratio of a study’s projected scientific and/or practical value to its total cost. By showing that a study’s projected value exhibits diminishing marginal returns as a function of increasing sample size for a wide variety of definitions of study value, we are able to develop two simple choices that can be defended as more cost efficient than any larger sample size. The first is to choose the sample size that minimizes the average cost per subject. The second is to choose sample size to minimize total cost divided by the square root of sample size. This latter method is theoretically more justifiable for innovative studies, but also performs reasonably well and has some justification in other cases. For example, if projected study value is assumed to be proportional to power at a specific alternative and total cost is a linear function of sample size, then this approach is guaranteed either to produce more than 90% power or to be more cost efficient than any sample size that does. These methods are easy to implement, based on reliable inputs, and well justified, so they should be regarded as acceptable alternatives to current conventional approaches