COMPARISON BETWEEN KOTHARI EDUCATION COMMISSION AND NEP-2020

This research article conducts a comprehensive comparative analysis of two significant educational policies in India: the Kothari Education Commission of 1964-66 and the National Education Policy (NEP) 2020. It seeks to discern the objectives, strategies, and outcomes of these pivotal policies, shedding light on their contributions to the evolution of the Indian education landscape. The Kothari Education Commission emerged during the post-independence era, addressing the urgent need to expand educational access while promoting quality and equity. In contrast, NEP-2020, developed against the backdrop of globalization, technological advancements, and shifting work dynamics, aims to equip learners for the challenges of the contemporary world. Through a meticulous examination of curriculum and pedagogical recommendations, strategies to enhance access and equity, approaches to teacher training and professional development, and implementation challenges, this study offers a nuanced understanding of the historical and contextual foundations of these policies. It also delves into their profound impact on education systems, students, and society. By juxtaposing these significant policies, this research article endeavours to uncover enduring lessons, achievements, and limitations. It aims to contribute to ongoing dialogues on education reform and policy development in India, fostering a deeper comprehension of the dynamic evolution of educational aspirations and strategies. It underscores India's steadfast commitment to education as a transformative force that shapes its destiny. The comparative analysis presented herein serves as an invaluable resource for policymakers, educators, researchers, and all stakeholders invested in India's educational future, providing insights from the past and present to guide the way forward

Implementation of Input Oriented Dynamic Voltage and Frequency Scaling for Multiplier on FPGA

This paper presents an Implementation of Dynamic voltage and frequency scaling according to input data. In the conventional method the power supply is fixed and independent on workload, so, voltage and area will be consumed unnecessary .Paper proposes the approach which focuses on making system dynamic for low power digital multiplier on reconfigurable device FPGA (Spartan III). For making system Dynamic input workload should be known and scanning is used to detect range of input so system can adjust voltage and frequency. Control signal generated from scanning which can dynamically change voltage and frequency for low power consumption according to input data

Estimation of Road Roughness Condition and Ghat Complexity Analysis Using Smartphone Sensors

Our system works on producing the result sets which shows the road conditions and ghat complexity during traveling. We all use the map but it does not show potholes and bumps in the road. Our system analyzes the data through the sensors of mobile phone such as sensors like accelerometer, orientation sensor, and magnetometer to analyze the ghat complexity and roads quality we use the GPS system of an android phone

Cystic fibrosis transmembrane conductance regulator (CFTR) gene abnormalities in Indian males with congenital bilateral absence of vas deferens & renal anomalies

Background & objectives: The role of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in congenital bilateral absence of vas deferens and unilateral renal agenesis (CBAVD-URA) has been controversial. Here, we report the cases of five Indian males with CBAVD-URA. The objective was to evaluate the presence or absence of CFTR gene mutations and variants in CBAVD-URA. The female partners of these males were also screened for cystic fibrosis (CF) carrier status. Methods: Direct DNA sequencing of CFTR gene was carried out in five Indian infertile males having CBAVD-URA. Female partners (n=5) and healthy controls (n=32) were also screened. Results: Three potential regulatory CFTR gene variants (c.1540A>G, c.2694T>G and c.4521G>A) were detected along with IVS8-5T mutation in three infertile males with CBAVD-URA. Five novel CFTR gene variants (c.621+91A>G, c.2752+106A>T, c.2751+85_88delTA, c.3120+529InsC and c.4375-69C>T), four potential regulatory CFTR gene variants (M470V, T854T, P1290P, Q1463Q) and seven previously reported CFTR gene variants (c.196+12T>C, c.875+40A>G, c.3041-71G>C, c.3271+42A>T, c.3272-93T>C, c.3500-140A>C and c.3601-65C>A) were detected in infertile men having CBAVD and renal anomalies Interpretation & conclusions: Based on our findings, we speculate that CBAVD-URA may also be attributed to CFTR gene mutations and can be considered as CFTR-related disorder (CFTR-RD). The CFTR gene mutation screening may be offered to CBAVD-URA men and their female partners undergoing ICSI. Further studies need to be done in a large sample to confirm the findings

Enhancing Surface Fault Detection Using Machine Learning for 3D Printed Products

In the era of Industry 4.0, the idea of 3D printed products has gained momentum and is also proving to be beneficial in terms of financial and time efforts. These products are physically built layer-by-layer based on the digital Computer Aided Design (CAD) inputs. Nonetheless, 3D printed products are still subjected to defects due to variation in properties and structure, which leads to deterioration in the quality of printed products. Detection of these errors at each layer level of the product is of prime importance. This paper provides the methodology for layer-wise anomaly detection using an ensemble of machine learning algorithms and pre-trained models. The proposed combination is trained offline and implemented online for fault detection. The current work provides an experimental comparative study of different pre-trained models with machine learning algorithms for monitoring and fault detection in Fused Deposition Modelling (FDM). The results showed that the combination of the Alexnet and SVM algorithm has given the maximum accuracy. The proposed fault detection approach has low experimental and computing costs, which can easily be implemented for real-time fault detection

Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure

Background: Premature Ovarian Failure (POF) is a disorder characterized by lack of ovulation and elevated serum gonadotrophin levels before the age of 40 years. The cause of POF in most cases is unknown. As mice lacking the Androgen Receptor (AR) gene reportedly have a POF-like phenotype, we hypothesize that, variations in the AR gene maybe one of the causative factors for POF in humans. Thus the objective of the study is to evaluate the number of CAG repeats in exon 1 of the AR gene in non-familial, non-syndromic cases of POF. Methods: A clinic-based case–control study. Seventy-eight patients with non-familial, non-syndromic POF and 90 controls were recruited to investigate the CAG repeat numbers in exon 1 of the AR gene by PCR and Gene Scan analysis. Results: The mean CAG repeat length in exon 1 of the AR gene of women with POF was 23.6 ± 3.8, which was significantly higher than controls (20.08 ± 3.45) (P < 0.001). The biallelic mean CAG repeat ranged from 11 to 32 in the control women, compared to 16 to 30 in the POF patients. The 22 CAG repeat allele followed by the 24 CAG repeat allele was found to be at highest frequency (15.38 and 12.8 %) in POF cases, although the 19 CAG repeat allele was observed at highest frequency (12.2%) in controls. Conclusions: The observation suggests that the CAG repeat length is increased in women with POF as compared with controls, and may be pathogenic for POF, at least in a subset of Indian women

Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure

Premature ovarian failure (POF) is a disorder of multicausal etiology leading to infertility in women. Development of ovarian auto-antibodies is a causative factor in most POF cases, but no consensus on the ovarian antigenic determinants has been reached till date. In the present study, sera from 15 POF cases, seven normally cycling women and eight menopausal women were studied by immunohistochemistry (IHC) for the presence of anti-ovarian antibodies. 10 of the 15 POF sera (66.6%) presented with anti-ovarian antibodies (Ao). Of these, two demonstrated antibodies to the zona pellucida (ZP) as well as strong immunoreactivity to granulosa cells (Azg), while the remaining eight exhibited anti-ZP antibodies with negligible staining in granulosa cells (Az). The antibodies showed cross-reactivity with ZP from various species such as human, sheep, marmoset, pig and mouse. Among various murine tissues, the antibodies cross-reacted only with thyroid and not with uterus, spleen, kidney, liver, adrenal, pancreas and pituitary. Five of the eight Az individuals presented with significant titres of anti-thyroid antibodies (Azt). In the control group, one menopausal control presented with reactivity to both ZP and GC, the autoimmunity possibly being a consequence of surgical trauma; while one normally cycling woman tested positive for anti-thyroid antibodies. The IHC results were confirmed by ELISA using heat-solubilized isolated ZP (SIZP) as the antigen. Out of seven Ao samples assessed by ELISA, five reacted with SIZP. Preincubation of these five samples with varying concentrations of SIZP demonstrated a dose-dependent decrease in reactivity in ELISA and abolished staining in IHC, confirming the specificity of auto-antibodies to ZP in the POF group. Our results thus suggest that ZP is an important ovarian antigen in autoimmune POF

Kaposi sarcoma (KS) with primary effusion lymphoma in HIV infected MSM (men having sex with men) co-infected with pulmonary tuberculosis and syphilis: a case report from India

Abstract We describe a case of a 30-year-old MSM recently diagnosed with HIV, immunocompromised with a purplish or brown rash all over the body for 3 to 4 months. The histopathology of the cutaneous lesions and pleural effusion aspirate confirmed the diagnosis of Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL). While KS is one of the AIDS-defining illnesses seen in immunocompromised patients having low CD4 count, PEL is a rare and distinct subset of AIDS-related lymphoma. Despite the widespread availability of HIV testing, HIV diagnosis gets delayed due to stigma among MSM. This case report emphasizes the importance of early suspicion for symptoms of HIV-associated opportunistic infections in high-risk populations like MSM. The report reiterates the need for an ambient stigma-free environment for improving HIV screening in this high-risk population