PaaSword: A Data Privacy and Context-aware Security Framework for Developing Secure Cloud Applications - Technical and Scientific Contributions

Most industries worldwide have entered a period of reaping the benefits and opportunities cloud offers. At the same time, many efforts are made to address engineering challenges for the secure development of cloud systems and software.With the majority of software engineering projects today relying on the cloud, the task to structure end-to-end secure-by-design cloud systems becomes challenging but at the same time mandatory. The PaaSword project has been commissioned to address security and data privacy in a holistic way by proposing a context-aware security-by-design framework to support software developers in constructing secure applications for the cloud. This chapter presents an overview of the PaaSword project results, including the scientific achievements as well as the description of the technical solution. The benefits offered by the framework are validated through two pilot implementations and conclusions are drawn based on the future research challenges which are discussed in a research agenda

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells

ZBTB7A is frequently mutated in acute myeloid leukemia (AML) with t(8;21) translocation. However, the oncogenic collaboration between mutated ZBTB7A and the RUNX1–RUNX1T1 fusion gene in AML t(8;21) remains unclear. Here, we investigate the role of ZBTB7A and its mutations in the context of normal and malignant hematopoiesis. We demonstrate that clinically relevant ZBTB7A mutations in AML t(8;21) lead to loss of function and result in perturbed myeloid differentiation with block of the granulocytic lineage in favor of monocytic commitment. In addition, loss of ZBTB7A increases glycolysis and hence sensitizes leukemic blasts to metabolic inhibition with 2-deoxy-d-glucose. We observed that ectopic expression of wild-type ZBTB7A prevents RUNX1-RUNX1T1-mediated clonal expansion of human CD34+ cells, whereas the outgrowth of progenitors is enabled by ZBTB7A mutation. Finally, ZBTB7A expression in t(8;21) cells lead to a cell cycle arrest that could be mimicked by inhibition of glycolysis. Our findings suggest that loss of ZBTB7A may facilitate the onset of AML t(8;21), and that RUNX1-RUNX1T1-rearranged leukemia might be treated with glycolytic inhibitors

Commentarii Super Librum Prophetiarum Jeremiae Tomus ...

Opera Sebastiani Schmidt S. Theol. Doctoris, in Universitate Argentoratensi Professoris Senioris ...Vorlageform des Erscheinungsvermerks: Francofurti Ad Moenum Sumptibus Johannis Davidis Zunneri. Typis Johannis Haasii Anno. MDCLXXXV.Ausz. aus kommentiertem Werk in hebr. und lat. SpracheErschienen: 1 (1685) - 2 (1685

Influence of Battery Cell Components and Water on the Thermal and Chemical Stability of LiPF6 Based Lithium Ion Battery Electrolytes

Lithium ion battery electrolytes based on LiPF6 and organic solvents are known to degrade at elevated temperatures. The degradation reactions can be caused either chemically e.g. by simple contact with battery cell components and/or electrochemically during cycling. This study is focused on thermally induced chemical reactions of the electrolyte with different battery cell components. These reactions are monitored by means of quantitative NMR spectroscopy. The results allow for categorizing the influences of the components according to their reactivity against HF. Inert materials (graphite, carbon black, polyvinylidene difluoride, polyolefinic and ceramic separator) do not show any observable influence on the thermal stability of the electrolyte. If the materials react with HF but the reaction does not form water in significant amounts (Li metal and LiNi1/3Co1/3Mn1/3O2), there is also no influence observable. In contrast to that, materials, which can form water in contact with HF at significant rates (glass fiber separator, Si and LiFePO4), can lead to a slightly increased or even severe electrolyte degradation. However, if the material neutralizes the acid HF (carboxymethyl cellulose), it stabilizes LiPF6 against water sources. Furthermore, the results of this study show that LiPF6 is stable at temperatures up to 80°C, if no water sources are present. This stability is most likely also given for even higher temperatures

Clinical performance of non-precious metal double crowns with friction pins in severely reduced dentitions

Objectives!#!Several in vitro studies have investigated the retention of double crowns with friction pins (DCP); however, clinical data on their long-term success have not been reported. We sought to evaluate the 5-year survival rate of DCPs in patients with severely reduced dentition (SRD) and not severely reduced dentition (NSRD).!##!Materials and methods!#!A total of 158 patients were treated with 182 dentures on 520 abutment teeth between 2006 and 2016. The SRD group included 144 dentures that had been inserted on 314 abutment teeth. We evaluated the influence of age, sex, jaw, number, tooth vitality, and abutment teeth localization (according to Steffel's classification) on the 60-month survival rates of dentures and abutment teeth using the Kaplan-Meier estimator, logrank test, and Cox regression.!##!Results!#!The cumulative 60-month survival rate was 84.3% (CI 77.1-91.5%) for all dentures; however, the survival rate in the SRD group (80.3%; CI 71.5-89.1%) was significantly lower than in the NSRD group (100%; p = 0.04). Dentures classified in Steffel's class A had the lowest survival rate (51.5%; CI 30.9-72.1%). Number, location, and vitality of the abutment teeth had a significant impact on survival rate.!##!Conclusions!#!DCP dentures showed comparable clinical long-term success to double crown systems that have been previously reported in the literature. The number, localization, and vitality of abutment teeth had the greatest influence on the survival rates of denture and abutment teeth.!##!Clinical relevance!#!DCP dentures have an acceptable 5-year survival rate. Clinical treatment planning must take into account key factors associated with the prognosis of the abutment teeth

Asymmetry effect of novel per(fluoroalkylsulfonyl)imide anions in pyrrolidinium ionic liquids

Ionic liquids based on the N-butyl-N-methylpyrrolidinium, (PYR14)(+), cation and different per(fluoroalkylsulfonyl) imide anions, having symmetric, (IM11)(-), moderately asymmetric, (IM24)(-), highly asymmetric, (IM14)(-) and (IMT4)(-), and cyclic, (IM3)(-) structures, were properly synthesized. A few of the presented per(fluoroalkylsulfonyl) imide ions have never been reported in the literature as ionic liquid anions. The thermal and transport properties of the ionic liquid materials, having a common cation, were investigated and correlated with the structure of the per(fluoroalkylsulfonyl) imide anion. The results have indicated that the symmetry as well as the steric hindrance of the anion affect the melting point and the crystallization kinetics as well as the ion conduction and the self-diffusion coefficient of the ionic liquids. The conductivity data are in good agreement with the thermal measurements

Evaluation of the Efficiency of Silica Removal in Effluents with (Zea Mays Var. Saccharata) in the Santa Rosa 94-1 Mining Concession in C.C. Llocllapampa, Jauja, Peru

In recent years in Peru, there are few non-metallic mining companies, one of the main ones being the Santa Rosa 94-1 mining concession, which is located in the community of Llocllapampa Jauja - Peru, where the main resource is silica sand that is used in this place, although it also generates a negative impact on the siliceous sand washing operation process since it modifies the conditions of the surface water since they do not have a treatment system. The objective of the research is to determine the efficiency and the amount of organic coagulant (Zea mays var. saccharata) for the removal of silica from the effluent in the mining concession. The characterization of the silica was carried out through petrographic analysis to know its composition, the effluent of the Total Suspended Solids (TSS) parameter was characterized, then it was designed factorially for 8 treatments with variation of the organic amendment, volume and time, which was applied to removal processes. After the analysis, they gave as a result that the non-metallic mining effluent generates a negative environmental impact on the ecosystem, comprising 15010 mg/L of TSS which exceeds the Maximum Permissible Limits, the combinations of organic amendment, effluent and time were developed, where in treatment 8 an average removal of 5,999 g/ml was obtained, which represents 88%, being the most efficient for silica removal