1 research outputs found
Digital subtraction radiographic analysis of the combination of bioabsorbable membrane and bovine morphogenetic protein pool in human periodontal infrabony defects
Objectives: This study assessed the bone density gain and its relationship with the
periodontal clinical parameters in a case series of a regenerative therapy procedure.
Material and Methods: Using a split-mouth study design, 10 pairs of infrabony defects from
15 patients were treated with a pool of bovine bone morphogenetic proteins associated with
collagen membrane (test sites) or collagen membrane only (control sites). The periodontal
healing was clinically and radiographically monitored for six months. Standardized presurgical
and 6-month postoperative radiographs were digitized for digital subtraction
analysis, which showed relative bone density gain in both groups of 0.034 ± 0.423 and
0.105 ± 0.423 in the test and control group, respectively (p>0.05). Results: As regards the
area size of bone density change, the influence of the therapy was detected in 2.5 mm2 in
the test group and 2 mm2 in the control group (p>0.05). Additionally, no correlation was
observed between the favorable clinical results and the bone density gain measured by
digital subtraction radiography (p>0.05). Conclusions: The findings of this study suggest
that the clinical benefit of the regenerative therapy observed did not come with significant
bone density gains. Long-term evaluation may lead to a different conclusions