Operational Techniques for Dealing with Long Eclipses During the MMS Extended Mission

Launch window design for the Magnetospheric Multiscale (MMS) mission ensured that no excessive eclipses would be encountered during the prime mission. However, no orbit solutions exist that satisfy the eclipse constraints indefinitely: most extended mission years contain 1-3 eclipses long enough to potentially damage either the spacecraft or its scientific instruments. Two steps were taken to improve the situation. Firstly, raising apogee radius from 25 to 29.34 Earth radii altered the Sun-Earth-MMS phasing, so efficiently achieving reductions in the long eclipse durations. These maneuvers were performed early this year, in preparation for the first pair of long eclipses in August 2019. Secondly, a set of operational steps were taken around the time of the eclipses to help maintain spacecraft and instrument temperatures while preventing power load shedding. These operational steps included raising key onboard temperatures through adjusting the spacecraft attitude to tilt the instrument deck towards the Sun, and engaging select heaters prior to going into eclipses. In addition, all scientific instruments were turned off, as well as high-power, non-critical spacecraft systems, to conserve energy.These steps each came with trade-offs which will be discussed in the paper. Finally, the results that were obtained when the spacecraft experienced the first extremely long eclipses will be discussed, as will lessons learned for future long eclipses

Visualizing sound emission of elephant vocalizations: evidence for two rumble production types

Recent comparative data reveal that formant frequencies are cues to body size in animals, due to a close relationship between formant frequency spacing, vocal tract length and overall body size. Accordingly, intriguing morphological adaptations to elongate the vocal tract in order to lower formants occur in several species, with the size exaggeration hypothesis being proposed to justify most of these observations. While the elephant trunk is strongly implicated to account for the low formants of elephant rumbles, it is unknown whether elephants emit these vocalizations exclusively through the trunk, or whether the mouth is also involved in rumble production. In this study we used a sound visualization method (an acoustic camera) to record rumbles of five captive African elephants during spatial separation and subsequent bonding situations. Our results showed that the female elephants in our analysis produced two distinct types of rumble vocalizations based on vocal path differences: a nasally- and an orally-emitted rumble. Interestingly, nasal rumbles predominated during contact calling, whereas oral rumbles were mainly produced in bonding situations. In addition, nasal and oral rumbles varied considerably in their acoustic structure. In particular, the values of the first two formants reflected the estimated lengths of the vocal paths, corresponding to a vocal tract length of around 2 meters for nasal, and around 0.7 meters for oral rumbles. These results suggest that African elephants may be switching vocal paths to actively vary vocal tract length (with considerable variation in formants) according to context, and call for further research investigating the function of formant modulation in elephant vocalizations. Furthermore, by confirming the use of the elephant trunk in long distance rumble production, our findings provide an explanation for the extremely low formants in these calls, and may also indicate that formant lowering functions to increase call propagation distances in this species'

MUSIC for sub/millimeter astrophysics

MUSIC (the Multiwavelength Submillimeter kinetic Inductance Camera) is an instrument being developed for the Caltech Submillimeter Observatory by Caltech, JPL, the University of Colorado, and UCSB. MUSIC uses microwave kinetic inductance detectors (MKIDs) - superconducting micro-resonators - as photon detectors. The readout is almost entirely at room temperature and is highly multiplexed. MUSIC will have 576 spatial pixels in four bands at 850, 1100, 1300 and 2000 microns. MUSIC is scheduled for deployment at the CSO in the winter of 2010/2011. We present an overview of the camera design and readout and describe the current status of the instrument and some results from the highly successful May/June 2010 observing run at the CSO with the prototype camera, which verified the performance of the complete system (optics, antennas/filters, resonators, and readout) and produced the first simultaneous 3-color observations with any MKID camera

Status of MUSIC, the MUltiwavelength Sub/millimeter Inductance Camera

We present the status of MUSIC, the MUltiwavelength Sub/millimeter Inductance Camera, a new instrument for the Caltech Submillimeter Observatory. MUSIC is designed to have a 14', diffraction-limited field-of-view instrumented with 2304 detectors in 576 spatial pixels and four spectral bands at 0.87, 1.04, 1.33, and 1.98 mm. MUSIC will be used to study dusty star-forming galaxies, galaxy clusters via the Sunyaev-Zeldovich effect, and star formation in our own and nearby galaxies. MUSIC uses broadband superconducting phased-array slot-dipole antennas to form beams, lumpedelement on-chip bandpass filters to define spectral bands, and microwave kinetic inductance detectors to sense incoming light. The focal plane is fabricated in 8 tiles consisting of 72 spatial pixels each. It is coupled to the telescope via an ambient-temperature ellipsoidal mirror and a cold reimaging lens. A cold Lyot stop sits at the image of the primary mirror formed by the ellipsoidal mirror. Dielectric and metal-mesh filters are used to block thermal infrared and out-ofband radiation. The instrument uses a pulse tube cooler and ^(3)He/^(3)He/^(4)He closed-cycle cooler to cool the focal plane to below 250 mK. A multilayer shield attenuates Earth's magnetic field. Each focal plane tile is read out by a single pair of coaxes and a HEMT amplifier. The readout system consists of 16 copies of custom-designed ADC/DAC and IF boards coupled to the CASPER ROACH platform. We focus on recent updates on the instrument design and results from the commissioning of the full camera in 2012

MUSIC for sub/millimeter astrophysics

MUSIC (the Multiwavelength Submillimeter kinetic Inductance Camera) is an instrument being developed for the Caltech Submillimeter Observatory by Caltech, JPL, the University of Colorado, and UCSB. MUSIC uses microwave kinetic inductance detectors (MKIDs) - superconducting micro-resonators - as photon detectors. The readout is almost entirely at room temperature and is highly multiplexed. MUSIC will have 576 spatial pixels in four bands at 850, 1100, 1300 and 2000 microns. MUSIC is scheduled for deployment at the CSO in the winter of 2010/2011. We present an overview of the camera design and readout and describe the current status of the instrument and some results from the highly successful May/June 2010 observing run at the CSO with the prototype camera, which verified the performance of the complete system (optics, antennas/filters, resonators, and readout) and produced the first simultaneous 3-color observations with any MKID camera

An open-source readout for MKIDs

This paper will present the design, implementation, performance analysis of an open source readout system for arrays of microwave kinetic inductance detectors (MKID) for mm/submm astronomy. The readout system will perform frequency domain multiplexed real-time complex microwave transmission measurements in order to monitor the instantaneous resonance frequency and dissipation of superconducting microresonators. Each readout unit will be able to cover up to 550 MHz bandwidth and readout 256 complex frequency channels simultaneously. The digital electronics include the customized DAC, ADC, IF system and the FPGA based signal processing hardware developed by CASPER group. The entire system is open sourced, and can be customized to meet challenging requirement in many applications: e.g. MKID, MSQUID etc

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.Leona M. and Harry B. Helmsley Charitable Trust (3-SRA-2014-285-M-R)United States. National Institutes of Health (EB000244)United States. National Institutes of Health (EB000351)United States. National Institutes of Health (DE013023)United States. National Institutes of Health (CA151884)United States. National Institutes of Health (P41EB015871-27)National Cancer Institute (U.S.) (P30-CA14051

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme