46,068 research outputs found
Recommended from our members
How Does Wind Project Performance Change with Age in the United States?
Wind-plant performance declines with age, and the rate of decline varies between regions. The rate of performance decline is important when determining wind-plant financial viability and expected lifetime generation. We determine the rate of age-related performance decline in the United States wind fleet by evaluating generation records from 917 plants. We find the rate of performance decline to be 0.53%/year for older vintages of plants and 0.17%/year for newer vintages of plants on an energy basis for the first 10 years of operation, which is on the lower end of prior estimates in Europe. Unique to the United States, we find a significant drop in performance by 3.6% after 10 years, as plants lose eligibility for the production tax credit. Certain plant characteristics, such as the ratio of blade length to nameplate capacity, influence the rate of performance decline. These results indicate that the performance decline rate can be partially managed and influenced by policy
Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes
Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster. RDL undergoes alternative splicing and RNA editing, which influence the potency of GABA. Most work has focussed on minority isoforms. Here, we report the first characterisation of the predominant native splice variant and RNA edit, combining functional characterisation with molecular modelling of the agonist-binding region. The relative order of agonist potency is GABA> muscimol> TACA> β-alanine. The I/V edit does not alter the potency of GABA compared to RDLbd. Docking calculations suggest that these agonists bind and activate RDLbdI/V through a similar binding mode. TACA and β-alanine are predicted to bind with lower affinity than GABA, potentially explaining their lower potency, whereas the lower potency of muscimol and isoguvacine cannot be explained structurally from the docking calculations. The A301S (resistance to dieldrin) mutation reduced the potency of antagonists picrotoxin, fipronil and pyrafluprole but the I/V edit had no measurable effect. Ivermectin suppressed responses to GABA of RDLbdI/V, RDLbd and RDLbdI/VA301S. The dieldrin resistant variant also showed reduced sensitivity to Ivermectin. This study of a highly abundant insect GABA receptor isoform will help the design of new insecticides
Degradation of a quantum directional reference frame as a random walk
We investigate if the degradation of a quantum directional reference frame
through repeated use can be modeled as a classical direction undergoing a
random walk on a sphere. We demonstrate that the behaviour of the fidelity for
a degrading quantum directional reference frame, defined as the average
probability of correctly determining the orientation of a test system, can be
fit precisely using such a model. Physically, the mechanism for the random walk
is the uncontrollable back-action on the reference frame due to its use in a
measurement of the direction of another system. However, we find that the
magnitude of the step size of this random walk is not given by our classical
model and must be determined from the full quantum description.Comment: 5 pages, no figures. Comments are welcome. v2: several changes to
clarify the key results. v3: journal reference added, acknowledgements and
references update
Comments on black holes I: The possibility of complementarity
We comment on a recent paper of Almheiri, Marolf, Polchinski and Sully who
argue against black hole complementarity based on the claim that an infalling
observer 'burns' as he approaches the horizon. We show that in fact
measurements made by an infalling observer outside the horizon are
statistically identical for the cases of vacuum at the horizon and radiation
emerging from a stretched horizon. This forces us to follow the dynamics all
the way to the horizon, where we need to know the details of Planck scale
physics. We note that in string theory the fuzzball structure of microstates
does not give any place to 'continue through' this Planck regime. AMPS argue
that interactions near the horizon preclude traditional complementarity. But
the conjecture of 'fuzzball complementarity' works in the opposite way: the
infalling quantum is absorbed by the fuzzball surface, and it is the resulting
dynamics that is conjectured to admit a complementary description.Comment: 34 pages, 6 figures, v3: clarifications & references adde
Timescale analysis of a mathematical model of acetaminophen metabolism andtoxicity
Acetaminophen is a widespread and commonly used painkiller all over the world. However, it can cause liver damage when taken in large doses or at repeated chronic doses. Current models of acetaminophen metabolism are complex, and limited to numerical investigation though provide results that represent clinical investigation well. We derive a mathematical model based on mass action laws aimed at capturing the main dynamics of acetaminophen metabolism, in particular the contrast between normal and overdose cases, whilst remaining simple enough for detailed mathematical analysis that can identify key parameters and quantify their role in liver toxicity. We use singular perturbation analysis to separate the di fferent timescales describing the sequence of events in acetaminophen metabolism, systematically identifying which parameters dominate during each of the successive stages. Using this approach we determined, in terms of the model parameters, the critical dose between safe and overdose cases, timescales for exhaustion and regeneration of important cofactors for acetaminophen metabolism and total toxin accumulation as a fraction of initial dose
Preserving Liveness Guarantees from Synchronous Communication to Asynchronous Unstructured Low-Level Languages
In the implementation of abstract synchronous communication in asynchronous unstructured low-level languages, e.g. using shared variables, the preservation of safety and especially liveness properties is a hitherto open problem due to inherently different abstraction levels. Our approach to overcome this problem is threefold: First, we present our notion of handshake refinement with which we formally prove the correctness of the implementation relation of a handshake protocol. Second, we verify the soundness of our handshake refinement, i.e., all safety and liveness properties are preserved to the lower level. Third, we apply our handshake refinement to show the correctness of all implementations that realize the abstract synchronous communication with the handshake protocol. To this end, we employ an exemplary language with asynchronous shared variable communication. Our approach is scalable and closes the verification gap between different abstraction levels of communication
Jet Trimming
Initial state radiation, multiple interactions, and event pileup can
contaminate jets and degrade event reconstruction. Here we introduce a
procedure, jet trimming, designed to mitigate these sources of contamination in
jets initiated by light partons. This procedure is complimentary to existing
methods developed for boosted heavy particles. We find that jet trimming can
achieve significant improvements in event reconstruction, especially at high
energy/luminosity hadron colliders like the LHC.Comment: 20 pages, 11 figures, 3 tables - Minor changes to text/figure
Six-Month Mortality among HIV-Infected Adults Presenting for Antiretroviral Therapy with Unexplained Weight Loss, Chronic Fever or Chronic Diarrhea in Malawi.
In sub-Saharan Africa, early mortality is high following initiation of antiretroviral therapy (ART). We investigated 6-month outcomes and factors associated with mortality in HIV-infected adults being assessed for ART initiation and presenting with weight loss, chronic fever or diarrhea, and with negative TB sputum microscopy
- …