Consumer attitudes to vaccination of food-producing animals

Summary The 2001 outbreak of foot and mouth disease in the United Kingdom was unprecedented, with the need to develop a vaccination policy at the height of the epidemic. The extent of consumer concerns about eating products derived from vaccinated animals was unknown as survey results were equivocal. A recent survey on avian influenza reveals that the European public are well informed about the disease and its control, but over 50% of respondents would be reluctant to consume meat from vaccinated birds. There is little specific information available on consumer views about routine vaccination for other diseases. Their concerns appear to increase in an emergency situation when there is heightened awareness through the media. With the development of newer types of vaccines consumers will need more assurance about the safety and use of these products. This article examines these issues and makes practical recommendations for ensuring public confidence when emergency vaccination for disease control is proposed

Medical Doctrines of Heredity.

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Impact of pre-harvest rainfall on the distribution of fusarium mycotoxins in wheat mill fractions

Legislative limits for Fusarium mycotoxins decrease from unprocessed wheat to processed products. A previous observational study identified a seasonal difference in the distribution of deoxynivalenol (DON) but not zearalenone (ZON) within mill fractions. Rainfall is known to influence the production of these mycotoxins in wheat, but the effects of rainfall on their distribution within mill fractions is not known. Laboratory and field experiments were conducted to determine the impact of different watering regimes on the distribution of DON and ZON in wheat mill fractions. Results indicated that repeated wetting and drying could cause movement of DON towards equilibrium across the mill fractions. Whereas, high levels of rainfall could cause a large reduction of DON in the grain, predominantly from the bran fraction, resulting in a proportional increase within white flour. ZON was detectable in fewer samples but results indicated it is less mobile within the grain. It is important for processors to be aware of the variation of mycotoxin distribution within mill fractions and the drivers of this variation to ensure limits set for grain intake result in mill products within mycotoxin legislative limits

Frontal Plane Knee Alignment: A Call for Standardized Measurement

Evaluations of knee alignment are useful in the diagnosis of arthritic conditions affecting the knee joint, serving also as a guide for conservative management and surgical planning. They are also fundamental to various aspects of musculo-skeletal research. Recently, there has been great interest in frontal plane alignment measures related to the pathogenesis of knee osteoarthritis (OA). Several approaches have been proposed over the years to describe and measure alignment, but the differences between them have made it difficult to compare or correlate the results of independent studies. Toward a standard approach to the measurement and reporting of alignment data that may be equally applicable to clinicians and researchers, we discuss a system of measurements based on geometric analysis of the femur, tibia, and knee joint surfaces. We also discuss a standardized methodology for measurement and computation of these parameters

A Comparative Analysis Of Army Body Composition Standards For Women

International Journal of Exercise Science 13(7): 1275-1282, 2020. The aim of this study was to compare body fat percentage (BF%) of women measured using the U.S. Army standard body composition assessment (ABC) and two common laboratory measures of body composition to evaluate the efficacy of ABC within this population. The BF% of 27 women (21.5 ± 1.8 years) was assessed using the 7-site skinfold, air plethysmography, and ABC measurements. The initial physical fitness test (IPFT) was used to determine if participants met the criteria required for admittance into basic combat training. A repeated measures ANOVA identified differences in BF% between the three assessment methods, (F (2, 52) = 22.83, p \u3c .001, η2p = .47). Pairwise comparisons revealed that mean BF% obtained using the ABC (29.3 ± 7.7 %) was significantly higher (p = .042) than BF% measured using air plethysmography (26.9 ± 8.4 %). ABC and air plethysmography measured BF% was significantly higher (both p \u3c .001) than BF% obtained from skinfold assessment (22.2 ± 5.9 %). Of the 27 total participants, 4 (14.8%) passed IPFT but failed to meet the Army body composition standards using the ABC method. The primary findings of this study suggest that the overestimation of BF% by the ABC method could lead to an unnecessary delay in enlistment for women approaching the upper threshold of the Army’s acceptable body composition standards. Alternative methods of assessing body composition in this population should be explored. However, skinfold assessment does not appear to be a suitable alternative to the ABC

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express normal levels of the TRAF6 protein. Remarkably, TRAF6[L74H] mice have none of the phenotypes seen in TRAF6 KO mice. Instead TRAF6[L74H] mice display an entirely different phenotype, exhibiting autoimmunity, and severe inflammation of the skin and modest inflammation of the liver and lungs. Similar to mice with a Treg-specific knockout of TRAF6, or mice devoid of TRAF6 in all T cells, the CD4(+) and CD8(+) T cells in the spleen and lymph nodes displayed an activated effector memory phenotype with CD44(high)/CD62L(low) expression on the cell surface. In contrast, T cells from WT mice exhibited the CD44(low)/CD62L(high) phenotype characteristic of naïve T cells. The onset of autoimmunity and autoinflammation in TRAF6[L74H] mice (two weeks) was much faster than in mice with a Treg-specific knockout of TRAF6 or lacking TRAF6 expression in all T cells (2–3 months) and we discuss whether this may be caused by secondary inflammation of other tissues. The distinct phenotypes of mice lacking TRAF6 expression in all cells appears to be explained by their inability to signal via TNF Receptor Superfamily members, which does not seem to be impaired significantly in TRAF6[L74H] mice