The motherhood penalties : insights from women in UK academia

We use an original survey of academic women in the UK to investigate different dimensions of the motherhood penalty. Being a mother has no effect on salaries, but still slows down career progression even in such a high-skilled sector. Motherhood has an ambivalent impact on women’s perception of their working environment: improving satisfaction, but reducing perception of salary fairness relative to men. Our paper also explores how different policies can mitigate the motherhood penalties. We find that more generous maternity provisions are associated with higher salary, potentially because generosity reduces the crowding out of research activity. Better availability of childcare and an even distribution of responsibilities within the household correlate positively with earnings. Our findings also highlight the importance of a supportive work environment for mothers’ career and well-being at the workplace. Taken together, these findings suggest the necessity of a multi-faceted policy response to the motherhood penalties

Motherhood in academia : a novel dataset with an application to maternity leave uptake

Legislation over the past two decades enhanced the availability and quantity of statutory maternity leave in the United Kingdom. In high-skilled sectors, many employers top up this maternity leave in an effort to retain and develop the careers of women. As leave provision became more generous, debates emerged as to the role, if any, these enhanced benefits have in retaining women in high status occupation and facilitating their career growth. Further, individual situations and employment status may prevent women from taking advantage of enhanced benefits. This paper presents findings from a comprehensive survey of thousands of women in the UK Higher Education sector and documents how the lives of academic mothers changed over the past quarter century. Contract status and the partner’s participation in parenting has significant effects on the types of maternity leave taken. We reflect on these findings and discuss future research in the area of labour market equity and productivity the availability of this comprehensive quantitative survey of academic women can facilitate

Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis

Objectives: To evaluate the prevalence of vitamin D deficiency and its impact on infections in HCV-related liver cirrhosis. Methods: We enrolled 291 patients affected by HCV-related liver cirrhosis. Serum vitamin D levels were dosed at enrolment. The presence of infection was assessed at baseline and during follow-up based on physical examination and laboratory analyses. Results: Vitamin D deficiency (15 (p = 0.003), Child-Pugh class B/C vs A (p < 0.001), and active hepatocellular carcinoma (HCC) (p < 0.001). At multivariate analysis, vitamin D deficiency (p < 0.01), HCC (p < 0.05), hospitalization (p < 0.001) and exposure to immunosuppressant agents (p < 0.05) were independent risk factors for infection at baseline. Conclusions: Vitamin D may play a role in the development of infections in patients affected by liver cirrhosis, and preventive strategies with vitamin D supplementation are to be evaluated in randomized controlled trials

A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis

We report a case of a 63-year-old Caucasian female referred to the cornea service of Clinica Oculistica with a neurotrophic corneal ulcer, decreased corneal sensitivity, absent corneal reflex, and decreased lacrimation. The medical record review was relevant for mastectomy and adjuvant therapy for breast cancer complicated by pontocerebellar angle metastasis. Eye patching and application of antibiotic and vitamin ointments were prescribed at first, without a significant improvement. Thus, treatment with autologous serum was started. In about two weeks, the cornea recovered and visual acuity improved with a residual corneal scarring. Finally, we should mention that, in our case, the main cause of the neurotrophic corneal ulcer could be identified in the previous trigeminal damage at the pontocerebellar angle and trigeminal ganglion. Sensory nerves play an important regulatory role via neuro-mediators on corneal wound healing, as denervation may interfere with cellular metabolism and inhibit mitosis, leading to an epithelial defect even with no direct damage

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

To describe a new objective technique of digital image analysis for the quantification and the morphological characterization of corneal staining in the setting of dry eye disease (DED), and to apply it to distinguish Sj\uf6gren syndrome (SS) from ocular graft versus-host disease (oGVHD)

Directional enhancement of refractive index and tunable wettability of polymeric coatings due to preferential dispersion of colloidal TiO2 nanorods towards their surface

Abstract We demonstrate the fabrication of nanocomposite coatings, of organic-capped colloidal TiO 2 nanorods dispersed into a poly(methyl methacrylate) matrix, with rising value of refractive index from the bottom to the top layers, and UV-induced surface wettability alteration, in a reversible manner. This behaviour is attributable to preferential dispersion of the TiO 2 nanoparticles towards the superficial layers of the coatings. Above a critical TiO 2 loading, the nanorods at the surface form aggregates deteriorating the optical and the surface properties of the nanocomposites. The optimal conditions for nanocomposite films preparation in terms of optimized nanorods dispersion, optical clarity, and surface smoothness are determined

Does compulsory vaccination limit personal freedom? Ethical issues

BackgroundDespite vaccinations are scientifically proven to be safe and effective public controversies limit their application in many countries.AimsAim of this review is to provide an overview of biological effects of vaccination and a picture of the ethical dilemmas about compulsory vaccination.Methods We conducted a review on the literature about the subject. Recent news were also included.Results Vaccines are the best weapon against many infectious diseases. The spread of false beliefs among people have led the government authorities to increase compulsory vaccination in order to embank new outbreaks of preventable infectious diseases.ConclusionEven if compulsory is quite drastic approach it could be the on only way to reach an adequate coverage and protect immunoexpressed subjects

Cytoreductive Surgery for Heavily Pre-Treated, Platinum-Resistant Epithelial Ovarian Carcinoma: A Two-Center Retrospective Experience

Few retrospective studies have shown a benefit in selected patients affected by heavily pre-treated, platinum-resistant ovarian carcinomas (PROCs) who have undergone cytoreduction at relapse. However, the role of tertiary and quaternary cytoreductive surgery is not fully defined. Our aim was to evaluate survival and surgical morbidity and mortality after maximal cytoreduction in this setting. We evaluated all consecutive patients undergoing cytoreduction for platinum-resistance over an 8-year period (2010&ndash;2018) in two different centers. Fifty patients (median age 52.5 years, range 34&ndash;75) were included; the median number of previous chemotherapy lines was three (range 1&ndash;7) and the median number of previous surgeries was one (range 1&ndash;4). Completeness of cytoreduction (CC = 0) was achieved in 22 patients (44%). Rates of major operative morbidity and 30-day mortality were 38% and 8%, respectively. Median follow-up was 35 months. The absence of tumor residual (CC = 0) was associated with a significantly better overall survival (OS) compared to the CC &gt; 0 subgroup (median OS 32.9 months (95% CI 21.6&ndash;44.2) vs. 4.8 months (95% CI n.a.&ndash;9.8), hazard ratio (HR) 4.21 (95% CI 2.07&ndash;8.60), p &lt; 0.001). Optimal cytoreduction is feasible and associated with promising OS in selected, heavily pre-treated PROCs. Further prospective studies are required to better define the role of surgery in platinum-resistant disease

Management of hepatitis B virus prophylaxis in patients treated with disease-modifying therapies for multiple sclerosis: a multicentric Italian retrospective study

Background: Patients with multiple sclerosis (MS) often receive disease-modifying therapies (DMTs) that can expose them to reactivation of potential occult hepatitis B virus (HBV) infection (pOBI). We aimed to evaluate the MS Centers behavior regarding HBV screening and prophylaxis in a large cohort of MS patients receiving anti-CD20 or cladribine. Methods: Retrospective, multicentric study recruiting Italian MS patients treated with rituximab, ocrelizumab and cladribine. Results: We included 931 MS patients from 15 centers. All but 38 patients performed a complete HBV screening. Patients' age &gt; 50&nbsp;years was significantly associated with no history of vaccination and HBsAb titres &lt; 100 mIU at baseline (p &lt; 0.001). No significant correlation was found between post-vaccination HBsAb titres and type of treatment (p = 0.5), pre-or post-therapy vaccination (p = 0.2) and number of previous DMTs (p = 0.2). Among pOBI patients (n = 53), 21 received antiviral prophylaxis, while only 13 had HBV DNA monitoring and 19 patients neither monitored HBV DNA nor received prophylaxis. Conclusions: Baseline HBV screening in patients receiving anti-CD20 and cladribine is a consolidated practice. Nonetheless, HBV vaccination coverage is still lacking in such population and age is a significant factor associated with low HBV protection. Rituximab, ocrelizumab and cladribine did not impair HBV vaccine response. Almost 35% of pOBI patients fail to receive HBVr prevention. Management of HBV prophylaxis could be improved in MS patients and further prospective studies are needed to assess the effectiveness of prophylactic strategies in such patients

Risk factors for respiratory function deterioration in patients hospitalised for COVID-19: The ASCL (Age, Sex, CRP, LDH) score

The pandemic of coronavirus disease 2019 has caused an unprecedent global social and economic impact, and high numbers of deaths. A good understanding of the possible risk factors is helpful for clinicians in identifying patients who are at high risk and require prioritised treatment to prevent disease progression and adverse outcome. In this retrospective multicenter study including patients hospitalised for COVID-19, the prognostic role of CRP and LDH at admission in predicting deterioration of respiratory function was evaluated. The results showed that both CRP and LDH at admission are associated with respiratory function deterioration during hospitalisation. Moreover a score composed of Age, Sex, CRP and LDH was also associated with significant respiratory deterioration. These parameters should be taken into account to choose patients to be prioritised for careful respiratory function monitoring and early treatment with specific drugs, in order to prevent a progression of the disease