Mortality and quality of life in the five years after severe sepsis

Peer reviewedPublisher PD

Early mobilisation in mechanically ventilated patients:A systematic integrative review of definitions and activities

From PubMed via Jisc Publications RouterHistory: received 2018-10-23, accepted 2018-12-11Publication status: epublishMechanically ventilated patients often develop muscle weakness post-intensive care admission. Current evidence suggests that early mobilisation of these patients can be an effective intervention in improving their outcomes. However, what constitutes early mobilisation in mechanically ventilated patients (EM-MV) remains unclear. We aimed to systematically explore the definitions and activity types of EM-MV in the literature. Whittemore and Knafl's framework guided this review. CINAHL, MEDLINE, EMBASE, PsycINFO, ASSIA, and Cochrane Library were searched to capture studies from 2000 to 2018, combined with hand search of grey literature and reference lists of included studies. The Critical Appraisal Skills Programme tools were used to assess the methodological quality of included studies. Data extraction and quality assessment of studies were performed independently by each reviewer before coming together in sub-groups for discussion and agreement. An inductive and data-driven thematic analysis was undertaken on verbatim extracts of EM-MV definitions and activities in included studies. Seventy-six studies were included from which four major themes were inferred: (1) , (2) , (3) and (4) . The first theme indicates that EM-MV is either not fully defined in studies or when a definition is provided this is not standardised across studies. The remaining themes reflect the diversity of EM-MV activities which depends on patients' characteristics and ICU settings; the negotiated decision-making process between patients and staff; and their interdependent relationship during the implementation. This review highlights the absence of an agreed definition and on what constitutes early mobilisation in mechanically ventilated patients. To advance research and practice an agreed and shared definition is a pre-requisite

COVID-19 infection and maternal morbidity in critical care units in Scotland: a national cohort study

No abstract available

Detecting and resolving inconsistencies between domain experts’ different perspectives on (classification) tasks

Objectives: The work reported here focuses on developing novel techniques which enable an expert to detect inconsistencies in 2 (or more) perspectives that the expert might have on the same (classification) task. The high level task which the experts (physicians) had set themselves was to classify, on a 5-point severity scale (A–E), the hourly reports produced by an intensive care unit's patient management system. <p/>Method: The INSIGHT system has been developed to support domain experts exploring, and removing inconsistencies in their conceptualization of a task. We report here a study of intensive care physicians reconciling 2 perspectives on their patients. The 2 perspectives provided to INSIGHT were an annotated set of patient records where the expert had selected the appropriate category to describe that snapshot of the patient, and a set of rules which are able to classify the various time points on the same 5-point scale. Inconsistencies between these 2 perspectives are displayed as a confusion matrix; moreover INSIGHT then allows the expert to revise both the annotated datasets (correcting data errors, or changing the assigned categories) and the actual rule-set. <p/>Results: Each of the 3 experts achieved a very high degree of consensus (∼97%) between his refined knowledge sources (i.e., annotated hourly patient records and the rule-set). We then had the experts produce a common rule-set and then refine their several sets of annotations against it; this again resulted in inter-expert agreements of ∼97%. The resulting rule-set can then be used in applications with considerable confidence. <p/>Conclusion: This study has shown that under some circumstances, it is possible for domain experts to achieve a high degree of correlation between 2 perspectives of the same task. The experts agreed that the immediate feedback provided by INSIGHT was a significant contribution to this successful outcome