Elevated Depressive Symptoms In A Community Sample Of African-Americans And Whites

This study examined demographic and psychosocial correlates of elevated depressive symptoms among African-Americans and Whites from comparable socioeconomic and neighborhood backgrounds. 851 African-Americans and 597 Whites from adjacent census tracts were interviewed using previously validated indicators of depressive symptoms, social support, religious practices and various demographic characteristics. More Whites than African-Americans reported elevated depressive symptoms and the groups also differed on several demographic variables and psychosocial variables. Employment, marital status and age were salient demographic covariates for African Americans, while income was for Whites. For both groups, social support and church attendance were inversely associated with depressive symptoms. Prayer was positively associated with depressive symptoms. Future research should explore within racial/ethnic group variations in depressive symptoms. Insights also are needed into possible changes over time in the relationship between religious variables and depressive symptoms, and how social support limits depressive symptoms in diverse populations

Critiquing the response to the Ebola epidemic through a primary health care approach

BACKGROUND: The 2014/2015 West Africa Ebola epidemic has caused the global public health community to engage in difficult self-reflection. First, it must consider the part it played in relation to an important public health question: why did this epidemic take hold and spread in this unprecedented manner? Second, it must use the lessons learnt to answer the subsequent question: what can be done now to prevent further such outbreaks in the future? These questions remain relevant, even as scientists announce that the Guinea Phase III efficacy vaccine trial shows that rVSV-EBOV (Merck, Sharp & Dohme) is highly efficacious in individuals. This is a major breakthrough in the fight against Ebola virus disease (EVD). It does not replace but may be a powerful adjunct to current strategies of EVD management and control. DISCUSSION: We contribute to the current self-reflection by presenting an analysis using a Primary Health Care (PHC) approach. This approach is appropriate as African countries in the region affected by EVD have recommitted themselves to PHC as a framework for organising health systems and the delivery of health services. The approach suggests that, in an epidemic made complex by weak pre-existing health systems, lack of trust in authorities and mobile populations, a broader approach is required to engage affected communities. In the medium-term health system development with attention to primary level services and community-based programmes to address the major disease burden of malaria, diarrhoeal disease, meningitis, tuberculosis and malnutrition is needed. This requires the development of local management and an investment in human resources for health. Crucially this has to be developed ahead of, and not in parallel with, future outbreaks. In the longer-term a commitment is required to address the underlying social determinants which make these countries so vulnerable, and limit their capacity to respond effectively to, epidemics such as EVD. CONCLUSION: The PHC approach offers an insightful critique of the global and regional factors which have compromised the response of health systems in Guinea, Liberia and Sierra Leone as well as suggesting what a strengthened EVD response might involve in the short, medium and long-term.Web of Scienc

How do Organisations Engage in Marketing Strategy Making? A Problemistic Search Perspective

Despite the importance of marketing strategy making (MSM) we understand little of how strategy making actually occurs within organisations. Departing from the common focus - on the tools and techniques of strategy– we apply a strategy as practice (SAP) lens to our exploration of MSM. We adopt a problemistic search perspective and utilise an in-depth case study to explore individual’s interactions in developing strategic marketing initiatives. We uncover a three-stage pattern in solution search within MSM; identification of the problem situation and postponing response, to problem recognition and acceptance, to a collective problem solving stage, which we label pre implementation consultation. The paper’s main contribution is the development of an initial framework placing a pre-implementation phase between formal and emergent strategy, providing a dynamic theory of MSM

Pre-slaughter assessment and selection in commercial beef cattle in relation to final carcase classification

The way we assess readiness for slaughter in beef cattle has not progressed in the past 200 years, with subjective visual and manual assessments of cattle still the primary mechanisms used to determine peak condition, resulting in less than half of all cattle carcases meeting a UK premium classification. Current losses to the UK Beef industry are estimated at approximately £12.5 million per year through the sending of over-fat and poorly conformed cattle to the abattoir. With global population rapidly increasing, there is a fundamental need to provide more food efficiently and effectively from the resources we have. Therefore, successfully reducing wastage and improving carcase quality across the UK beef industry through accurate assessment and selection of beef cattle for slaughter is an important step forwards towards a sustainable future for beef production. The EUROP system of bovine carcase classification dictates which carcases are most desired for the current market, with those failing to meet market specification subject to a penalty. The aim of this research project was therefore to provide farmers with an objective tool using a binary logistic regression model, to combine fat and morphometric measurements taken from live cattle, in order to help predict which cattle are most likely to achieve a desired carcase classification and therefore most suitable for slaughter. Through the use of a series of binary logistic regression models, it was discovered that out of 15 measurements taken from cattle, a combination of pelvis height, pelvis width, 10th and 12th rib fat point readings and the P8 fat point reading were best able to predict the likelihood of cattle meeting a UK premium carcase classification. In a later study, when breed was factored into the model on a larger, more commercial scale, this reduced the number of measurements required to just the pelvis width and 12th rib fat point reading, subsequently increasing the practicality to apply this research on-farm

Effectiveness of Criminal Justice Liaison and Diversion Services for Offenders With Mental Disorders: A Review

Objective: The authors reviewed studies of the effectiveness of criminal justice liaison and diversion (CJLD) services in which outcomes of participants in these services were compared with those of offenders with mental illness who received no intervention or a standard intervention. The authors synthesized existing evidence with respect to changes in mental health status or criminal recidivism. Methods: A comprehensive search (1980–2012) of more than 30 generic and specialist databases identified 6,571 published and unpublished studies. The studies, which varied considerably in methodological approach and overall quality, were systematically appraised according to Campbell-Cochrane guidelines. Ten studies met inclusion criteria. Key outcomes included a reduction in offending and postintervention changes in mental health. Results: Synthesized findings indicated that CJLD services appeared to be effective in identifying offenders with mental disorders and that participation in CJLD services had a positive impact on criminal justice and mental health outcomes. Conclusions: Although the methodologies of existing studies are only moderately rigorous, the overall findings suggest that CJLD services can be beneficial. Their effectiveness depends on the model of service delivery, the availability of community services, and the engagement of offenders with mental disorders in treatment. The successful implementation of CJLD services requires a clearer recognition of the importance of systems-of-care principles

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes

Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). POS is a PhD student supported by the Scottish Government (RESAS) and the Science Foundation Ireland, through a centre award to the APC Microbiome Institute, Cork, Ireland. Data Summary The high-quality draft genomes generated in this work were deposited at the European Nucleotide Archive under the following accession numbers: 1. Eubacterium rectale T1-815; CVRQ01000001–CVRQ0100 0090: http://www.ebi.ac.uk/ena/data/view/PRJEB9320 2. Roseburia faecis M72/1; CVRR01000001–CVRR010001 01: http://www.ebi.ac.uk/ena/data/view/PRJEB9321 3. Roseburia inulinivorans L1-83; CVRS01000001–CVRS0 100 0151: http://www.ebi.ac.uk/ena/data/view/PRJEB9322Peer reviewedPublisher PD

Managing for change: October 11, 1989

Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the hospital

Functionalisation of bolaamphiphiles with mononuclear bis(2,2'-bipyridyl)ruthenium(II) complexes for application in self assembled monolayers

A novel ruthenium(II) polypyridyl complex connected competently to a bolaamphiphile, containing amide linkages to provide rigidity via hydrogen bonding in the monolayer, has been prepared. The ruthenium(II) complexes of this ligand and of the intermediates in the synthesis were prepared by modification of the coordinated ligands, demonstrating the synthetic versatility and robustness of this family of complexes. All ruthenium complexes were characterised by electrochemical and spectroscopic techniques and were found to have similar properties to the parent complex [Ru(bipy)[3]][2][+], and remain versatile photosensitisers, with well-defined properties, despite extensive substitution of the bipy ligand

The extragalactic radio-source population at 95 GHz

We have used the Australia Telescope Compact Array (ATCA) at 95GHz to carry out continuum observations of 130 extragalactic radio sources selected from the Australia Telescope 20GHz (AT20G) survey. Over 90% of these sources are detected at 95 GHz, and we use a triple-correlation method to measure simultaneous 20 and 95 GHz flux densities. We show that the ATCA can measure 95GHz flux densities to ~10% accuracy in a few minutes for sources above ~50mJy. The median 20-95GHz spectral index does not vary significantly with flux density for extragalactic sources with S20>150 mJy. This allows us to estimate the extragalactic radio source counts at 95GHz by combining our observed 20-95GHz spectral-index distribution with the accurate 20GHz source counts measured in the AT20G survey. The resulting 95GHz source counts down to 80 mJy are significantly lower than those found by several previous studies. The main reason is that most radio sources with flat or rising spectra in the frequency range 5-20GHz show a spectral turnover between 20 and 95 GHz. As a result, there are fewer 95GHz sources (by almost a factor of two at 0.1 Jy) than would be predicted on the basis of extrapolation from the source populations seen in lower-frequency surveys. We also derive the predicted confusion noise in CMB surveys at 95GHz and find a value 20-30% lower than previous estimates. The 95GHz source population at the flux levels probed by this study is dominated by QSOs with a median redshift z~1. We find a correlation between optical magnitude and 95GHz flux density which suggests that many of the brightest 95 GHz sources are relativistically beamed, with both the optical and millimetre continuum significantly brightened by Doppler boosting.Comment: Replaced with final version (MNRAS, in press), 15 pages plus two landscape data table

Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.

BackgroundNeural tube defects (NTDs), which are among the most common congenital malformations, are influenced by environmental and genetic factors. Low maternal folate is the strongest known contributing factor, making variants in genes in the folate metabolic pathway attractive candidates for NTD risk. Multiple studies have identified nominally significant allelic associations with NTDs. We tested whether associations detected in a large Irish cohort could be replicated in an independent population.MethodsReplication tests of 24 nominally significant NTD associations were performed in racially/ethnically matched populations. Family-based tests of fifteen nominally significant single nucleotide polymorphisms (SNPs) were repeated in a cohort of NTD trios (530 cases and their parents) from the United Kingdom, and case-control tests of nine nominally significant SNPs were repeated in a cohort (190 cases, 941 controls) from New York State (NYS). Secondary hypotheses involved evaluating the latter set of nine SNPs for NTD association using alternate case-control models and NTD groupings in white, African American and Hispanic cohorts from NYS.ResultsOf the 24 SNPs tested for replication, ADA rs452159 and MTR rs10925260 were significantly associated with isolated NTDs. Of the secondary tests performed, ARID1A rs11247593 was associated with NTDs in whites, and ALDH1A2 rs7169289 was associated with isolated NTDs in African Americans.ConclusionsWe report a number of associations between SNP genotypes and neural tube defects. These associations were nominally significant before correction for multiple hypothesis testing. These corrections are highly conservative for association studies of untested hypotheses, and may be too conservative for replication studies. We therefore believe the true effect of these four nominally significant SNPs on NTD risk will be more definitively determined by further study in other populations, and eventual meta-analysis