12,292 research outputs found
Making a financial time machine:a multitouch application to enable interactive 3-D visualization of distant savings goals
Financial planning and decision making for the general public continues to vex and perplex in equal measure. Whilst the tools presented by a typical desktop computer should make the task easier, the recent financial crisis confirms the increasing difficulty that people have in calculating the benefits of deferring consumption for future gains (i.e. Saving). We present an interactive concept demonstration for Microsoft SurfaceTM that tackles two of the key barriers to saving decision making. Firstly we show an interface that avoid the laborious writing down or inputting of data and instead embodies the cognitive decision of allocation of resources in a physical gesture based interface, where the scale of the investment or expenditure correlates with the scale of the gesture. Second we show how a fast-forward based animation can demonstrate the impact of small increments in savings to a long term savings goal in a strategy game-based, interactive format. The platform uses custom software (XNATM format) as opposed to the more usual WPFTM format found on Surface applications. This enables dynamic 3-D graphical icons to be used to maximize the interactive appeal of the interface. Demonstration and test trial feedback indicates that this platform can be adapted to suit the narrative of individual purchasing decisions to inform educate diverse user groups about the long term consequences of small financial decisions
Statistical mechanics of multipartite entanglement
We characterize the multipartite entanglement of a system of n qubits in
terms of the distribution function of the bipartite purity over all balanced
bipartitions. We search for those (maximally multipartite entangled) states
whose purity is minimum for all bipartitions and recast this optimization
problem into a problem of statistical mechanics.Comment: final versio
Limitations for change detection in multiple Gabor targets
We investigate the limitations on the ability to detect when a target has changed, using Gabor targets as simple quantifiable stimuli. Using a partial report technique to equalise response variables, we show that the log of the Weber fraction for detecting a spatial frequency change is proportional to the log of the number of targets, with a set-size effect that is greater than that reported for visual search. This is not a simple perceptual limitation, because pre-cueing a single target out of four restores performance to the level found when only one target is present. It is argued that the primary limitation on performance is the division of attention across multiple targets, rather than decay within visual memory. However in a simplified change detection experiment without cueing, where only one target of the set changed, not only was the set size effect still larger, but it was greater at 2000 msec ISI than at 250 msec ISI, indicating a possible memory component. The steepness of the set size effects obtained suggests that even moderate complexity of a stimulus in terms of number of component objects can overload attentional processes, suggesting a possible low-level mechanism for change blindness
Canonical and Microcanonical Distributions for Fermi Systems
Recursion relations are presented that allow exact calculation of canonical
and microcanonical partition functions of degenerate Fermi systems, assuming no
explicit two-body interactions. Calculations of the level density, sorted by
angular momentum, are presented for Ni-56 are presented. The issue of treating
unbound states is also addressed.Comment: 5 pages, 5 figure
Classical Statistical Mechanics Approach to Multipartite Entanglement
We characterize the multipartite entanglement of a system of n qubits in
terms of the distribution function of the bipartite purity over balanced
bipartitions. We search for maximally multipartite entangled states, whose
average purity is minimal, and recast this optimization problem into a problem
of statistical mechanics, by introducing a cost function, a fictitious
temperature and a partition function. By investigating the high-temperature
expansion, we obtain the first three moments of the distribution. We find that
the problem exhibits frustration.Comment: 38 pages, 10 figures, published versio
Multi-dye theranostic nanoparticle platform for bioimaging and cancer therapy
Amit K Singh,1,2 Megan A Hahn,2 Luke G Gutwein,3 Michael C Rule,4 Jacquelyn A Knapik,5 Brij M Moudgil,1,2 Stephen R Grobmyer,3 Scott C Brown,2,61Department of Materials Science and Engineering, College of Engineering, 2Particle Engineering Research Center, College of Engineering, 3Division of Surgical Oncology, Department of Surgery, College of Medicine, 4Cell and Tissue Analysis Core, McKnight Brain Institute, 5Department of Pathology, College of Medicine, University of Florida, Gainesville, FL, USA; 6DuPont Central Research and Development, Corporate Center for Analytical Science, Wilmington, DE, USABackground: Theranostic nanomaterials composed of fluorescent and photothermal agents can both image and provide a method of disease treatment in clinical oncology. For in vivo use, the near-infrared (NIR) window has been the focus of the majority of studies, because of greater light penetration due to lower absorption and scatter of biological components. Therefore, having both fluorescent and photothermal agents with optical properties in the NIR provides the best chance of improved theranostic capabilities utilizing nanotechnology.Methods: We developed nonplasmonic multi-dye theranostic silica nanoparticles (MDT-NPs), combining NIR fluorescence visualization and photothermal therapy within a single nanoconstruct comprised of molecular components. A modified NIR fluorescent heptamethine cyanine dye was covalently incorporated into a mesoporous silica matrix and a hydrophobic metallo-naphthalocyanine dye with large molar absorptivity was loaded into the pores of these fluorescent particles. The imaging and therapeutic capabilities of these nanoparticles were demonstrated in vivo using a direct tumor injection model.Results: The fluorescent nanoparticles are bright probes (300-fold enhancement in quantum yield versus free dye) that have a large Stokes shift (>110 nm). Incorporation of the naphthalocyanine dye and exposure to NIR laser excitation results in a temperature increase of the surrounding environment of the MDT-NPs. Tumors injected with these NPs are easily visible with NIR imaging and produce significantly elevated levels of tumor necrosis (95%) upon photothermal ablation compared with controls, as evaluated by bioluminescence and histological analysis.Conclusion: MDT-NPs are novel, multifunctional nanomaterials that have optical properties dependent upon the unique incorporation of NIR fluorescent and NIR photothermal dyes within a mesoporous silica platform.Keywords: bioluminescence, in vivo imaging, mesoporous silica nanoparticles, NIR fluorescence, photothermal ablation, theranosti
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âWeâre not all dangerous and crazyâ. Negotiating the voice hearing identity: A critical discursive approach
A critical discursive approach examined how the voice hearing identity is negotiated. Conflicting constructions identified voice hearing not only as distressing but also as a normal experience. The discursive strategies reveal that when individuals who hear voices construct their identity, they must either disavow their own distress to avoid stigma or accept the stigmatising accounts of their identity imposed on them if they are to have their distress recognised. The study points to the value and importance of discursive approaches in uncovering unspoken distress in individuals and society, and towards the need to address identity issues in clinical and social interventions
AMI-LA Observations of the SuperCLASS Super-cluster
We present a deep survey of the SuperCLASS super-cluster - a region of sky
known to contain five Abell clusters at redshift - performed using
the Arcminute Microkelvin Imager (AMI) Large Array (LA) at 15.5GHz. Our
survey covers an area of approximately 0.9 square degrees. We achieve a nominal
sensitivity of Jy beam toward the field centre, finding 80
sources above a threshold. We derive the radio colour-colour
distribution for sources common to three surveys that cover the field and
identify three sources with strongly curved spectra - a high-frequency-peaked
source and two GHz-peaked-spectrum sources. The differential source count (i)
agrees well with previous deep radio source count, (ii) exhibits no evidence of
an emerging population of star-forming galaxies, down to a limit of 0.24mJy,
and (iii) disagrees with some models of the 15GHz source population.
However, our source count is in agreement with recent work that provides an
analytical correction to the source count from the SKADS Simulated Sky,
supporting the suggestion that this discrepancy is caused by an abundance of
flat-spectrum galaxy cores as-yet not included in source population models.Comment: 17 pages, 14 figures, 3 tables. Accepted for publication in MNRA
The anatomy of melancholia: Focal abnormalities of cerebral blood flow in major depression
The Compound Action Potential in Subjects Receiving a Cochlear Implant
The compound action potential (CAP) is a purely neural component of the cochleaâs response to sound, and may provide information about the existing neural substrate in cochlear implant (CI) subjects that can help account for variance in speech perception outcomes
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