Prospectus, November 9, 1976

ADAMS AND PARKS: RUNNERS HEAD FOR NEW YORK; Business as usual: Stu-Go discusses \u27disaster bus\u27, pins; Computer data banks on you; Final exam schedules posted; PC news in brief: Big Walter here today, Library open Dec. 18, See Chicago Bulls Nov. 30, Buy a ticket, turkey!, Christmas shopping trip, College Forum; Traditional Vet\u27s Day; What does it mean?: Chapter 11, Nobel winner; Letters; Big Walter Horton plays today; Alexander Prospectus ad manager; Teachers, too: H.S. Students visit this week; Museum trip scheduled for Nov. 20; Senior citizen play preview planned for Nov. 17th; Exploring new worlds living in Outer Space; Asses make basketball players of themselves; Capsule to be buried; Campus Life band hit with audience; Don\u27t worry about it: Midterms are only an indication, not a grade; Classifieds; Football poll deals with playoffs, other concerns; Bears exceed, STP needs boost; Spikers could net national berth this weekend; Fisher ignores tip, wins Fast Freddy; Fast Freddy\u27s Football Forecast; Cobra\u27s Corner: Adams getting antsy for New York meet; PC students can swim free on Tuesdays; I.M. finals approaching; Games of November 13-14https://spark.parkland.edu/prospectus_1976/1004/thumbnail.jp

Prospectus, November 23, 1976

TRUSTEES MEET: 25% TUITION INCREASE VOTED BY BOARD, NEW HOUR TOTAL $17; PC news in brief: Redford stars in \u27Jeremiah Johnson\u27, Spring Schedule changed, Sociological film today, See Chicago Bulls Nov. 30; Till Nov. 30th: Preregister now; \u27Disaster bus\u27 being fixed, should be ready by Jan.; Persecutor\u27s life changed; Illinois low in educ. support; Onarga application approved; 28% late on stud. loans; Before finals: Withdraw by December 15th; GI Bill: New vet allowances announced; Sign up now to save courses for later; Campus competition: Gunki heads stud. recognition; Library stairs sculpture just hanging around for 2 years; Theta Epsilon meets Dec. 1; Senior university: Sangamon State rep visits today; Care and cooking: There\u27s more to wild game than just hunting it; Flipping the bird...a collection of turkey recipes: First, the real one; Then, some recipes by for turkeys...: ...figure five pounds per person, ...I forgot to say to take the turkey out of the bag, ...watch the expressions of delight as they eat it; Timeless marital problems looked at in Coward play; Artist-in-residence: Wayne Forbes: showing need for people to care; Santa Claus arrives Friday; Theta Epsilon Frat. officers announced; Community Cultural Series: Twain Amer. Humor superb; Fifth Column: False Promises of entertainment; Classifieds; Cobra\u27s Corner: 3 candidates for center: Betka is \u27all-business\u27 vying for starting position; Bears still 1st, \u27Excess\u27 within 3 points; Schedule changed: Cagers open tonite at DuPage; Parkland Basketball Roster; Cobra captains ready; Decker wins final Freddy; Lockers must be renewed; Parkland College 1976-1977 Basketball Schedule; Women\u27s Basketball Schedulehttps://spark.parkland.edu/prospectus_1976/1002/thumbnail.jp

Prospectus, September 28, 1976

PINS\u27 COMING SOON; Gonzalez and Steffey ineligible: McCabe, Kirkpatrick elected; 25%-33%: Drop rate high; Stewart speaks to com 111 \u27I love the business\u27; Faculty plans \u2777-\u2778 curriculum; Letters to the editor: Pins still bouncing, Oops, We\u27re waiting; Guest Editorial: Mellowspread does not mind campaign attack on Mr. Big ; Student activities provides \u27Driver exchange board\u27; Vandalizes and burns own car; Jesus Christ is alive and well: Hold everything!; Guest opinion: containers big waste; \u27Antonia\u27 on Thursday; PC news in brief: Game tourney, Joe Matthews, It\u27s debatable, Scott to speak, Peanuts popcorn candy, IOC, Soc. Assoc. wake-up, Kirk elected president, Weight control seminar; United Way needs more than donations: Walker wants community help; Tau Epsilon gleans local corn fields; Head Start Follow-Up tutor program; Nadia will dance Oct. 5; Dear Bonnie; Prairie Festival; Burgoo treat of the day; Concert review: Basie Band swings, Williams sings; \u27Birthday Party\u27 opens tomorrow; Coral Reefers back him up: Buffet a hit at auditorium; Uncle Bob\u27s review: Debate get you down?; Elvis tickets for concert sold out: Classifieds; Cobra\u27s Corner: Abbey named USCSC games committee; First home volleyball game tonight; Mudrock 1st, Cobras 6th; Bob Zettler wins Fast Freddy; Fast Freddy\u27s Football Forecast; Harriers bow to Illini JVs; Games of October 2https://spark.parkland.edu/prospectus_1976/1010/thumbnail.jp

Project Team

for their guidance and vision on this project. The Center team would like to extend our appreciation to the many individuals who devoted their time and resources to make this handbook possible. Several individuals supplied site plans for consideration, took time to visit sites, reviewed codes and ordinances, and provided more detailed information on the case studies

Guidance for engendering ecosystem services for urban transformation

Growing urbanisation and climate change present a number of important challenges to ensuring more sustainable development in the future. All human activities impact on the natural environment, especially cities. How urban development is undertaken and managed has implications for present and future wellbeing. This guidance focusses on how natural capital and its associated ecosystem services (ES) can be understood within the context of the urban environment. It focuses on how different ES can be incorporated into sustainable urban development and planning, as a natural asset that can reduce peoples risk and vulnerability, and improve their wellbeing.This summary guidance aims to highlight how natural capital based ES can be seen as an ‘asset’ which can improve the well-being of communities, and the women and men, girls and boys that live within them.It draws on existing findings about how environmental assets such as parks, street trees, water features and private gardens can contribute to human well-being, applied to the Brazilian context through an exploratory study centred in Nova Contagem, a peripheral suburb of Belo Horizonte.It uses experience of undertaking the study to provide practical guidance in how to:-Undertake an assessment of the environmental assets present in a community-Evaluate the potential for urban environmental assets to yield ecosystem services - services such as Regulating (cooling shade), Provisioning (food and fuel), and Cultural (space for gathering / taking exercise) - and the nature of the goods, benefits, and at times dis-benefits, natural capital assets deliverThe findings of the study provide guidance around:-How people understand what the environment is, and how they value, or not, different types of urban environmental assets-The ecosystem services and dis-services they derive from the natural environment-How environmental assets interact with other assets to improve well beingThe premise of the study is that access to urban environmental assets and the ecosystem services they provide, is not equal for all within a community or a household, and in particular women and men will have different access to these and other assets. The study then also provides insights into:-Differences in women and men’s understandings of the environment and its potential for improving well being-Differences in women and men’s access to environmental assets and the ecosystem services they may provide-Actions that could be taken to improve gender equality of access to ecosystem servicesUltimately the guide seeks to provide recommendations on what local authorities and community organisations can do to ensure that the existing environmental assets are valued and protected and the beneficial services are maximised and made accessible to all, while the dis-services are minimised

Prospectus, September 23, 1981

CANDIDATES VOICE THEIR VIEWS; News In Brief; Parkland P adds to landscape; Editors voice opinions; Homeowners can save; WPCD to broadcast football; Football plan goes into effect; New club formed at Parkland; U of I to study special lottery; Scholarships offered to women; Free seminar offered; Vietnam vets made more; Students may still sign up for insurance; Neil Simon\u27s hit musical showing soon; PC offers 3-hour telecourse; Create your own decorations; Classifieds; Beware of Matt\u27s addiction ; McNichol, Hamill star in Georgia ; Two top bands to perform at ISU; C-U Symphony kicks off season Saturday; Assembly Hall offers ticket deals; LRC helps students and faculty; Area\u27s next cash crop?: Some farmers try sunflowers; Mark predicts election results; Drug from sea may hold new hope for cancer and herpes; Newhart to visit C-U area; Speech team needs help; Record shops may become obsolete; VB team loses opener; ...but wins 2nd game; Parkland College Basketball Schedule -- Women 1981-82; Golf team wins against Danville; Sports Notes; Cross Country team off to running start; Airsho offers good timehttps://spark.parkland.edu/prospectus_1981/1012/thumbnail.jp

MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors

Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (iBD) and colitis-associated cancer (CAC). Myeloid translocation gene 16 (MTG16, also known as CBFA2T3) is a transcriptional corepressor expressed in the colonic epithelium. MTG16 deficiency in mice exacerbates colitis and increases tumor burden in CAC, though the underlying mechanisms remain unclear. Here, we identified MTG16 as a central mediator of epithelial differentiation, promoting goblet and restraining enteroendocrine cell development in homeostasis and enabling regeneration following dextran sulfate sodium-induced (DSS-induced) colitis. Transcriptomic analyses implicated increased Ephrussi box-binding transcription factor (E protein) activity in MTG16-deficient colon crypts. Using a mouse model with a point mutation that attenuates MTG16:E protein interactions (Mtg16(P20ST)), we showed that MTG16 exerts control over colonic epithelial differentiation and regeneration by repressing E protein-mediated transcription. Mimicking murine colitis, MTG16 expression was increased in biopsies from patients with active IBD compared with unaffected controls. Finally, uncoupling MTG16:E protein interactions partially phenocopied the enhanced tumorigenicity of Mtg16(-/)(-) colon in the azoxymethane/DSS-induced model of CAC, indicating that MTG16 protects from tumorigenesis through additional mechanisms. Collectively, our results demonstrate that MTG16, via its repression of E protein targets. is a key regulator of cell fate decisions during colon homeostasis, colitis, and cancer.Peer reviewe

Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array

Purpose The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 mL of formulation using a hollow microneedle delivery device designed for self-application. Methods 3M’s hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate delivery of a variety of formulations including small molecule salts and proteins. Blood samples were collected after delivery and analyzed via HPLC or ELISA to provide a PK profile for the delivered drug. Site evaluations were conducted post delivery to determine skin tolerability. Results Up to 1.5 mL of formulation was infused into swine at a max rate of approximately 0.25 mL/min. A red blotch, the size of the hMTS array, was observed immediately after patch removal, but had faded so as to be almost indistinguishable 10 min post-patch removal. One-mL deliveries of commercial formulations of naloxone hydrochloride and human growth hormone and a formulation of equine anti-tetanus toxin were completed in swine. With few notable differences, the resulting PK profiles were similar to those achieved following subcutaneous injection of these formulations. Conclusions 3M’s hMTS can provide rapid, intradermal delivery of 300–1,500 µL of liquid formulations of small molecules salts and proteins, compounds not typically compatible with passive transdermal delivery. KEY WORDS transdermal drug delivery. microneedles. intradermal. hollow microstructures. MT

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray

The Quiescent Intracluster Medium in the Core of the Perseus Cluster

Clusters of galaxies are the most massive gravitationally-bound objects in the Universe and are still forming. They are thus important probes of cosmological parameters and a host of astrophysical processes. Knowledge of the dynamics of the pervasive hot gas, which dominates in mass over stars in a cluster, is a crucial missing ingredient. It can enable new insights into mechanical energy injection by the central supermassive black hole and the use of hydrostatic equilibrium for the determination of cluster masses. X-rays from the core of the Perseus cluster are emitted by the 50 million K diffuse hot plasma filling its gravitational potential well. The Active Galactic Nucleus of the central galaxy NGC1275 is pumping jetted energy into the surrounding intracluster medium, creating buoyant bubbles filled with relativistic plasma. These likely induce motions in the intracluster medium and heat the inner gas preventing runaway radiative cooling; a process known as Active Galactic Nucleus Feedback. Here we report on Hitomi X-ray observations of the Perseus cluster core, which reveal a remarkably quiescent atmosphere where the gas has a line-of-sight velocity dispersion of 164+/-10 km/s in a region 30-60 kpc from the central nucleus. A gradient in the line-of-sight velocity of 150+/-70 km/s is found across the 60 kpc image of the cluster core. Turbulent pressure support in the gas is 4% or less of the thermodynamic pressure, with large scale shear at most doubling that estimate. We infer that total cluster masses determined from hydrostatic equilibrium in the central regions need little correction for turbulent pressure.Comment: 31 pages, 11 Figs, published in Nature July