4,361 research outputs found
An estimate of \Omega_m without priors
Using mean relative peculiar velocity measurements for pairs of galaxies, we
estimate the cosmological density parameter and the amplitude of
density fluctuations . Our results suggest that our statistic is a
robust and reproducible measure of the mean pairwise velocity and thereby the
parameter. We get and . These estimates do not depend on prior assumptions on
the adiabaticity of the initial density fluctuations, the ionization history,
or the values of other cosmological parameters.Comment: 12 pages, 4 figures, slight changes to reflect published versio
Synthesis of bioinspired collagen/alginate/fibrin based hydrogels for soft tissue engineering
Hydrogels based on natural polymers offer a range of properties to mimic the native extracellular matrix, and provide microenvironments to preserve cellular function and encourage tissue formation. A tri-component hydrogel using collagen, alginate and fibrin (CAF) was developed and investigated at three collagen concentrations for application as a functional extracellular matrix analogue. Physical-chemical characterization of CAF hydrogels demonstrated a thermo-responsive crosslinking capacity at physiological conditions with stiffness similar to native soft tissues. CAF hydrogels were also assessed for cytocompatibility using L929 murine fibroblasts, pancreatic MIN6 β-cells and human mesenchymal stem cells (hMSCs); and demonstrated good cell viability, proliferation and metabolic activity after 7 days of in vitro culture. CAF hydrogels, especially with 2.5% w/v collagen, increased alkaline phosphatase production in hMSCs indicating potential for the promotion of osteogenic activity. Moreover, CAF hydrogels also increased metabolic activity of MIN6 β-cells and promoted the reconstitution of spherical pseudoislets with sizes ranging between 50 and 150 μm at day 7, demonstrating potential in diabetic therapeutic applications
Teaching tolerance
Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human lysosomal acid α glucosidase (GAA, rhGAA), ERT unfortunately leads to the development of high titers of anti-rhGAA antibody, decreased effectiveness of ERT, and a fatal outcome for a significant number of children who have Pompe disease. The severity of disease, anti-drug antibody (ADA) development, and the consequences thereof are directly related to the degree of the enzyme deficiency. Babies born with a complete deficiency GAA are said to have cross-reactive immunologic material (CRIM)–negative Pompe disease and are highly likely to develop GAA ADA. Less frequently, GAA ADA develop in CRIM-positive individuals. Currently, GAA-ADA sero-positive babies are treated with a combination of immunosuppressive drugs to induce immunological tolerance to ERT, but the long-term effect of these regimens is unknown. Alternative approaches that might redirect the immune response toward antigen-specific tolerance without immunosuppressive agents are needed. Methods leading to the induction of antigen-specific regulatory T cells (Tregs), using peptides such as Tregitopes (T regulatory cell epitopes) are under consideration for the future treatment of CRIM-negative Pompe disease. Tregitopes are natural T cell epitopes derived from immunoglobulin G (IgG) that cause the expansion and activation of regulatory T cells (Treg). Teaching the immune system to tolerate GAA by co-delivering GAA with Tregitope peptides might dramatically improve the lives of CRIM-negative babies and could be applied to other enzyme replacement therapies to which ADA have been induced
Continent-Wide Survey Reveals Massive Decline in African Savannah Elephants
African elephants (Loxodonta africana) are imperiled by poaching and habitat loss. Despite global attention to the plight of elephants, their population sizes and trends are uncertain or unknown over much of Africa. To conserve this iconic species, conservationists need timely, accurate data on elephant populations. Here, we report the results of the Great Elephant Census (GEC), the first continent-wide, standardized survey of African savannah elephants. We also provide the first quantitative model of elephant population trends across Africa. We estimated a population of 352,271 savannah elephants on study sites in 18 countries, representing approximately 93% of all savannah elephants in those countries. Elephant populations in survey areas with historical data decreased by an estimated 144,000 from 2007 to 2014, and populations are currently shrinking by 8% per year continent-wide, primarily due to poaching. Though 84% of elephants occurred in protected areas, many protected areas had carcass ratios that indicated high levels of elephant mortality. Results of the GEC show the necessity of action to end the African elephants’ downward trajectory by preventing poaching and protecting habitat
Very Low Mass Stellar and Substellar Companions to Solar-Like Stars From MARVELS V: A Low Eccentricity Brown Dwarf from the Driest Part of the Desert, MARVELS-6b
We describe the discovery of a likely brown dwarf (BD) companion with a
minimum mass of 31.7 +/- 2.0 M_Jup to GSC 03546-01452 from the MARVELS radial
velocity survey, which we designate as MARVELS-6b. For reasonable priors, our
analysis gives a probability of 72% that MARVELS-6b has a mass below the
hydrogen-burning limit of 0.072 M_Sun, and thus it is a high-confidence BD
companion. It has a moderately long orbital period of 47.8929 +0.0063/-0.0062
days with a low eccentricty of 0.1442 +0.0078/-0.0073, and a semi-amplitude of
1644 +12/-13 m/s. Moderate resolution spectroscopy of the host star has
determined the following parameters: T_eff = 5598 +/- 63, log g = 4.44 +/-
0.17, and [Fe/H] = +0.40 +/- 0.09. Based upon these measurements, GSC
03546-01452 has a probable mass and radius of M_star = 1.11 +/- 0.11 M_Sun and
R_star = 1.06 +/- 0.23 R_Sun with an age consistent with less than ~6 Gyr at a
distance of 219 +/- 21 pc from the Sun. Although MARVELS-6b is not observed to
transit, we cannot definitively rule out a transiting configuration based on
our observations. There is a visual companion detected with Lucky Imaging at
7.7 arcsec from the host star, but our analysis shows that it is not bound to
this system. The minimum mass of MARVELS-6b exists at the minimum of the mass
functions for both stars and planets, making this a rare object even compared
to other BDs.Comment: 15 pages, 15 figures, 5 tables. Accepted for publication in The
Astronomical Journa
Searching for Long Strings in CMB Maps
Using analytical methods and Monte Carlo simulations, we analyze new
statistics designed to detect isolated step-like discontinuities which are
coherent over large areas of Cosmic Microwave Background (CMB) pixel maps. Such
coherent temperature discontinuities are predicted by the Kaiser-Stebbins
effect to form due to long cosmic strings present in our present horizon. The
background of the coherent step-like seed is assumed to be a scale invariant
Gaussian random field which could have been produced by a superposition of
seeds on smaller scales and/or by inflationary quantum fluctuations. We find
that the proposed statistics can detect the presense of a coherent
discontinuity at a sensitivity level almost an order of magnitude better
compared to more conventional statistics like the skewness or the kurtosis.Comment: 10 pages, 3 Figures, Use RevTe
AMI observations of unmatched Planck ERCSC LFI sources at 15.75 GHz
The Planck Early Release Compact Source Catalogue includes 26 sources with no
obvious matches in other radio catalogues (of primarily extragalactic sources).
Here we present observations made with the Arcminute Microkelvin Imager Small
Array (AMI SA) at 15.75 GHz of the eight of the unmatched sources at
declination > +10 degrees. Of the eight, four are detected and are associated
with known objects. The other four are not detected with the AMI SA, and are
thought to be spurious.Comment: 6 pages, 5 figures, 4 table
A Cautionary Tale: MARVELS Brown Dwarf Candidate Reveals Itself To Be A Very Long Period, Highly Eccentric Spectroscopic Stellar Binary
We report the discovery of a highly eccentric, double-lined spectroscopic
binary star system (TYC 3010-1494-1), comprising two solar-type stars that we
had initially identified as a single star with a brown dwarf companion. At the
moderate resolving power of the MARVELS spectrograph and the spectrographs used
for subsequent radial-velocity (RV) measurements (R ~ <30,000), this particular
stellar binary mimics a single-lined binary with an RV signal that would be
induced by a brown dwarf companion (Msin(i)~50 M_Jup) to a solar-type primary.
At least three properties of this system allow it to masquerade as a single
star with a very low-mass companion: its large eccentricity (e~0.8), its
relatively long period (P~238 days), and the approximately perpendicular
orientation of the semi-major axis with respect to the line of sight (omega~189
degrees). As a result of these properties, for ~95% of the orbit the two sets
of stellar spectral lines are completely blended, and the RV measurements based
on centroiding on the apparently single-lined spectrum is very well fit by an
orbit solution indicative of a brown dwarf companion on a more circular orbit
(e~0.3). Only during the ~5% of the orbit near periastron passage does the
true, double-lined nature and large RV amplitude of ~15 km/s reveal itself. The
discovery of this binary system is an important lesson for RV surveys searching
for substellar companions; at a given resolution and observing cadence, a
survey will be susceptible to these kinds of astrophysical false positives for
a range of orbital parameters. Finally, for surveys like MARVELS that lack the
resolution for a useful line bisector analysis, it is imperative to monitor the
peak of the cross-correlation function for suspicious changes in width or
shape, so that such false positives can be flagged during the candidate vetting
process.Comment: 16 pages, 11 figures, 6 table
Non-Vacuum Initial States for Cosmological Perturbations of Quantum-Mechanical Origin
In the context of inflation, non-vacuum initial states for cosmological
perturbations that possess a built in scale are studied. It is demonstrated
that this assumption leads to a falsifiable class of models. The question of
whether they lead to conflicts with the available observations is addressed.
For this purpose, the power spectrum of the Bardeen potential operator is
calculated and compared with the CMBR anisotropies measurements and the
redshift surveys of galaxies and clusters of galaxies. Generic predictions of
the model are: a high first acoustic peak, the presence of a bump in the matter
power spectrum and non-Gaussian statistics. The details are controlled by the
number of quanta in the non-vacuum initial state. Comparisons with observations
show that there exists a window for the free parameters such that good
agreement between the data and the theoretical predictions is possible.
However, in the case where the initial state is a state with a fixed number of
quanta, it is shown that this number cannot be greater than a few. On the other
hand, if the initial state is a quantum superposition, then a larger class of
initial states could account for the observations, even though the state cannot
be too different from the vacuum. Planned missions such as the MAP and Planck
satellites and the Sloan Survey, will demonstrate whether the new class of
models proposed here represents a viable alternative to the standard theory.Comment: revtex, 15 pages, 10 figures. Submitted to Phys.Rev.
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