Categorisation of designs according to preference values for shape rules

Shape grammars have been used to explore design spaces through design generation according to sets of shape rules with a recursive process. Although design space exploration is a persistent issue in computational design research, there have been few studies regarding the provision of more preferable and refined outcomes to designers. This paper presents an approach for the categorisation of design outcomes from shape grammar systems to support individual preferences via two customised viewpoints: (i) absolute preference values of shape rules and (ii) relative preference values of shape rules with shape rule classification levels with illustrative examples

Advanced nickel-cadmium batteries for geosynchronous spacecraft

A nickel cadmium battery was developed that can be operated at 80 percent depth of discharge in excess of 10 years in a geosynchronous orbit application, and has about a 30 percent weight savings per spacecraft over present nickel cadmium batteries when used with a 1000 watts eclipse load. The approach used in the development was to replace nylon separators with inert polymer impregnated zirconia, use electrochemically deposited plates in place of conventional chemically precipitated ones, and use an additive to extend negative plate lifetime. The design has undergone extensive testing using both engineering and protoflight cell configurations

Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer

1.7 million cases of breast cancer are diagnosed every year with 522,000 deaths. Molecular classifications of breast cancer have resulted in improved treatments. However, treatments for triple negative breast cancer (TNBC) are lacking. Analysis of molecular targets for TNBC is a priority. One potential candidate is androgen receptor (AR) phosphorylation. This study assessed the role of AR phosphorylation at ser81/ser515 and their two upstream effectors, cyclin-dependent kinase 1 (pCDK1) and extracellular-regulated kinase 1/2 (pERK1/2) in 332 ductal breast cancer patients by immunohistochemistry. pERK1/2 combined with AR-515 associated with improved cancer-specific survival (CSS, p = 0.038), decreased size (p = 0.001), invasive grade (p < 0.001), necrosis (p = 0.003), b-lymphocytes (p = 0.020), molecular subtype (p < 0.001) and estrogen receptor (ER)/progesterone receptor (PR)-status (p < 0.001). The cohort was therefore stratified into ER+ve and ER-ve patients. In ER+ve tumours, pERK1/2 combined with AR-515 associated with improved CSS (p = 0.038), smaller size (p = 0.004), invasive grade (p = 0.001), decreased b-lymphocytes (p = 0.013) and increased plasma cells (p = 0.048). In contrast, in TNBC patients, phosphorylation of AR-515 associated with poorer CSS (p = 0.007). pERK1/2 combined with AR-515 associated with decreased inflammation (p = 0.003), increased tumour stroma (p = 0.003) and tumour budding (p = 0.011), with trends towards decrease CSS (p = 0.065) and macrophage levels (p = 0.093). In Conclusions, AR-515 may be an important regulator of inflammation in breast cancer potential via ERK1/2 phosphorylation. AR-515 is a potential prognostic marker and therapeutic target for TNBC

Shape exploration in design : formalising and supporting a transformational process

The process of sketching can support the sort of transformational thinking that is seen as essential for the interpretation and reinterpretation of ideas in innovative design. Such transformational thinking, however, is not yet well supported by computer-aided design systems. In this paper, outcomes of experimental investigations into the mechanics of sketching are described, in particular those employed by practising architects and industrial designers as they responded to a series of conceptual design tasks,. Analyses of the experimental data suggest that the interactions of designers with their sketches can be formalised according to a finite number of generalised shape rules. A set of shape rules, formalising the reinterpretation and transformations of shapes, e.g. through deformation or restructuring, are presented. These rules are suggestive of the manipulations that need to be afforded in computational tools intended to support designers in design exploration. Accordingly, the results of the experimental investigations informed the development of a prototype shape synthesis system, and a discussion is presented in which the future requirements of such systems are explored

“Flipping or flapping?” Investigating engineering students’ experience in flipped classrooms

Purpose This study has explored the flipped classroom model in a private university in Malaysia. It aims to present a flipped classroom intervention for engineering education innovation. Design/methodology/approach The research (1) revisited prominent educational theories for a flipping or flapping pedagogy, (2) implemented and explored the flipped classroom experiences in one engineering subject using the action inquiry method with thematic analysis and (3) reflectively evaluated both students’ and educators’ “flipping or flapping experience”. Findings The responses of the research participants are analysed and used to develop the flipping or flapping classroom principles and an ideal flipped classroom model. From passive lectures to active learning with collaborative discourse and reflective communication, flipping the classroom can offer a seamless learning experience. Research limitations/implications The flipped classroom model can provide good reference for other educational researchers who intended to conduct a flipped classroom. However, the small sample size with qualitative method and thematic analysis useds led to considerable theoretical development, but it may not achieve the validity standards to generalise the findings. Further empirical investigation with a systematic controlled group is recommended for future work across disciplines for extrapolation. Originality/value This is a genuine case study with an identified innovative teaching need to investigate how flipped classrooms can be enabled and enhanced in engineering education innovation

Undergraduate Sport Management Students’ Perceptions of Leadership Skills Through Service Learning

Researchers have discovered that service learning affects students’ academic, personal, and social development. However, currently there is a gap in literature analyzing ways in which service learning affects students’ perceived leadership skills. This study examined the effectiveness of service learning on the perceived leadership skills of 74 sport management undergraduate students at a mid-sized, Midwestern, public university using Kouzes’ and Posner’s Student Leadership Practices Inventory instrument, which examines leadership practices in five areas: Model the Way, Inspire a Shared Vision, Challenge the Process, Enable Others to Act, and Encourage the Heart. The results of this study may help faculty members and administrators to better understand the potential of utilizing service learning projects in their classrooms as a vehicle for their students to develop quality leadership practices. Recommendations for further research and practice are also discussed

William Edwards Ladd, M.D. (1880-1967): the description of his bands.

In the early 20th century, an established surgical specialty catering to pediatric surgery did not exist, and pediatric surgical ailments were operated on by general surgeons. With his devotion to childhood diseases and his unique thinking in surgical development, William E. Ladd would become a leading figure in America by pioneering the field of pediatric surgery