Redesigning the Curriculum for Aviation Maintenance Apprenticeships: Integrating Social and Reflective Practices

Competencies have been used for many years to align the values, behaviour, knowledge, and skills of individuals with the goals of the organizations in which they are employed. The organization in which I am employed in the role as a technical instructor, previously did not have a curriculum in place to support a competency-based model for the apprentices who are working in an aviation maintenance capacity. This action research paper outlines the redesigned curriculum, grafting reflective and social learning aspects; the result of is intended to affect positive change in the learning practices of both the individual and organization

Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability.

There is increasing evidence that the lysosome is involved in the pathogenesis of a variety of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to the disruption of neuronal homeostasis offer opportunities to understand the molecular underpinnings of neurodegeneration and potentially identify specific therapeutic targets. Here, using a monogenic neurodegenerative disorder, NPC1 disease, we demonstrate that reduced cholesterol efflux from lysosomes aberrantly modifies neuronal firing patterns. The molecular mechanism linking alterations in lysosomal cholesterol egress to intrinsic tuning of neuronal excitability is a transcriptionally mediated upregulation of the ABCA1 transporter, whose PtdIns(4,5)P2-floppase activity decreases plasma membrane PtdIns(4,5)P2. The consequence of reduced PtdIns(4,5)P2 is a parallel decrease in a key regulator of neuronal excitability, the voltage-gated KCNQ2/3 potassium channel, which leads to hyperexcitability in NPC1 disease neurons. Thus, cholesterol efflux from lysosomes regulates PtdIns(4,5)P2 to shape the electrical and functional identity of the plasma membrane of neurons in health and disease

LOFT-1 Mission: New Concepts For Educational and Commercial Spaceflight

The Launch Operations Flight Test One (LOFT-1) was originally conceived by E\u27Prime Aerospace Corporation (EPAC) of Titusville, Florida, as strictly an administrative pathfinder toward satisfying all governmental requirements for conducting commercial spaceflight activities from the Cape Canaveral Air Force Station (CCAFS). As the program progressed from early June 1987 toward the original launch date set in the Fall, the complexion of the flight changed dramatically to one of a bonafide scientific mission. Four individual educational/commercial organizations agreed to provide experiments. As such, LOFT-1 would mark the first launch of a privately developed and funded suborbital vehicle carrying payloads from the CCAFS. The University of Alabama in Huntsville, by way of participants within the Industrial and Systems Engineering Department, volunteered to serve as a focal point for all LOFT-1 payload design and integration tasks. In addition, UAH went on to design and develop its own experiment. Given only a few short months between conception of the mission and the originally planned flight date of October 1^, 1987, it was necessary to define a close-knit team, literally from across the nation, to make the mission possible within the original time constraint

Application of Neuro-Fuzzy Technique+2:9s to Predict Ground Water Vulnerability in Northwest Arkansas

Contamination of ground water has been a major concern in recent years of local, state and federal agencies involved with the management, quality, and quantity of water and their relationships with human health. The Springfield Plateau aquifer, which lies beneath the study area in northwest Arkansas, has been shown to have higher nitrate-N (NO3-N) concentrations than the national median. The dominant landuse (LULC) of this area is agriculture (primarily pasture/cattle and woodlands) and an encroaching urbanization. The major sources of nitrogen in the study area are poultry/cattle wastes, inorganic fertilizers (Peterson et. al., 1998) and septic filter fields. Many of the soils in the Ozark Region are highly permeable and well drained and the geology is karst. The probability of pollution occurring at a given location is a function not only of its hydrogeologic setting but also of anthropogenic pollution in the area (Evans, 1990)

Recent Trends in Heat-Related Mortality in the United States: An Update Through 2018

Much research has shown a general decrease in the negative health response to extreme heat events in recent decades. With a society that is growing older, and a climate that is warming, whether this trend can continue is an open question. Using eight additional years of mortality data, we extend our previous research to explore trends in heat-related mortality across the United States. For the period 1975–2018, we examined the mortality associated with extreme-heat-event days across the 107 largest metropolitan areas. Mortality response was assessed over a cumulative 10-day lag period following events that were defined using thresholds of the excess heat factor, using a distributed-lag nonlinear model. We analyzed total mortality and subsets of age and sex. Our results show that in the past decade there is heterogeneity in the trends of heat-related human mortality. The decrease in heat vulnerability continues among those 65 and older across most of the country, which may be associated with improved messaging and increased awareness. These decreases are offset in many locations by an increase in mortality among men 45–64 (+1.3 deaths per year), particularly across parts of the southern and southwestern United States. As heat-warning messaging broadly identifies the elderly as the most vulnerable group, the results here suggest that differences in risk perception may play a role. Further, an increase in the number of heat events over the past decade across the United States may have contributed to the end of a decades-long downward trend in the estimated number of heat-related fatalities

Soils of Mississippi County, Arkansas

Along with air and water, soil contributes essential processes to the natural order of global cycles. With the exception of edibles from the sea, virtually everything we, and most other land-based animals, eat is derived from soil. Soil is a storage medium of essential minerals and nutrients for fulfilling our agricultural and nutritional needs. Humans work the soil to provide the basics of food, clothing, and shelter. We also use the soil as a medium to store and discard our waste. Virtually everything we do is in some way connected to soi

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3\u27UTR AU-rich elements (AREs). Here, we examine the therapeutic potential of targeting HuR using MS-444, a small molecule HuR inhibitor. Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. Mechanistically, MS-444 disrupted HuR cytoplasmic trafficking and released ARE-mRNAs for localization to P-bodies, but did not affect total HuR expression levels. This resulted in MS-444-mediated inhibition of COX-2 and other ARE-mRNA expression levels. Importantly, MS-444 was well tolerated and inhibited xenograft CRC tumor growth through enhanced apoptosis and decreased angiogenesis upon intraperitoneal administration. In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors. These findings provide evidence that therapeutic strategies to target HuR in CRC warrant further investigation in an effort to move this approach to the clinic

A global analysis of genetic interactions in Caenorhabditis elegans

Abstract Background Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the nematode Caenorhabditis elegans. Results We investigated interactions between 11 'query' mutants in conserved signal transduction pathways and hundreds of 'target' genes compromised by RNA interference (RNAi). Mutant-RNAi combinations that grew more slowly than controls were identified, and genetic interactions inferred through an unbiased global analysis of the interaction matrix. A network of 1,246 interactions was uncovered, establishing the largest metazoan genetic-interaction network to date. We refer to this approach as systematic genetic interaction analysis (SGI). To investigate how genetic interactions connect genes on a global scale, we superimposed the SGI network on existing networks of physical, genetic, phenotypic and coexpression interactions. We identified 56 putative functional modules within the superimposed network, one of which regulates fat accumulation and is coordinated by interactions with bar-1(ga80), which encodes a homolog of β-catenin. We also discovered that SGI interactions link distinct subnetworks on a global scale. Finally, we showed that the properties of genetic networks are conserved between C. elegans and Saccharomyces cerevisiae, but that the connectivity of interactions within the current networks is not. Conclusions Synthetic genetic interactions may reveal redundancy among functional modules on a global scale, which is a previously unappreciated level of organization within metazoan systems. Although the buffering between functional modules may differ between species, studying these differences may provide insight into the evolution of divergent form and function

On the kinks and dynamical phase transitions of alpha-helix protein chains

Heuristic insights into a physical picture of Davydov's solitonic model of the one-dimensional protein chain are presented supporting the idea of a non-equilibrium competition between the Davydov phase and a complementary, dynamical- `ferroelectric' phase along the chainComment: small latex file with possible glue problems, just go on !, no figures, small corrections with respect to the published text, follow-up work to cond-mat/9304034 [PRE 47 (June 1993) R3818

Multi-Regge kinematics and the moduli space of Riemann spheres with marked points

We show that scattering amplitudes in planar N = 4 Super Yang-Mills in multi-Regge kinematics can naturally be expressed in terms of single-valued iterated integrals on the moduli space of Riemann spheres with marked points. As a consequence, scattering amplitudes in this limit can be expressed as convolutions that can easily be computed using Stokes' theorem. We apply this framework to MHV amplitudes to leading-logarithmic accuracy (LLA), and we prove that at L loops all MHV amplitudes are determined by amplitudes with up to L + 4 external legs. We also investigate non-MHV amplitudes, and we show that they can be obtained by convoluting the MHV results with a certain helicity flip kernel. We classify all leading singularities that appear at LLA in the Regge limit for arbitrary helicity configurations and any number of external legs. Finally, we use our new framework to obtain explicit analytic results at LLA for all MHV amplitudes up to five loops and all non-MHV amplitudes with up to eight external legs and four loops.Comment: 104 pages, six awesome figures and ancillary files containing the results in Mathematica forma