6,139 research outputs found
CARMA CO(J = 2 - 1) Observations of the Circumstellar Envelope of Betelgeuse
We report radio interferometric observations of the 12C16O 1.3 mm J = 2-1
emission line in the circumstellar envelope of the M supergiant Alpha Ori and
have detected and separated both the S1 and S2 flow components for the first
time. Observations were made with the Combined Array for Research in
Millimeter-wave Astronomy (CARMA) interferometer in the C, D, and E antenna
configurations. We obtain good u-v coverage (5-280 klambda) by combining data
from all three configurations allowing us to trace spatial scales as small as
0.9\arcsec over a 32\arcsec field of view. The high spectral and spatial
resolution C configuration line profile shows that the inner S1 flow has
slightly asymmetric outflow velocities ranging from -9.0 km s-1 to +10.6 km s-1
with respect to the stellar rest frame. We find little evidence for the outer
S2 flow in this configuration because the majority of this emission has been
spatially-filtered (resolved out) by the array. We also report a SOFIA-GREAT
CO(J= 12-11) emission line profile which we associate with this inner higher
excitation S1 flow. The outer S2 flow appears in the D and E configuration maps
and its outflow velocity is found to be in good agreement with high resolution
optical spectroscopy of K I obtained at the McDonald Observatory. We image both
S1 and S2 in the multi-configuration maps and see a gradual change in the
angular size of the emission in the high absolute velocity maps. We assign an
outer radius of 4\arcsec to S1 and propose that S2 extends beyond CARMA's field
of view (32\arcsec at 1.3 mm) out to a radius of 17\arcsec which is larger than
recent single-dish observations have indicated. When azimuthally averaged, the
intensity fall-off for both flows is found to be proportional to R^{-1}, where
R is the projected radius, indicating optically thin winds with \rho \propto
R^{-2}.Comment: 11 pages, 8 figures To be published in the Astronomical Journal
(Received 2012 February 10; accepted 2012 May 25
Ariel - Volume 7 Number 2
Editors
Mark Dembert
Frank Chervanek
John Lammie
Jim Burke
Curt Cumming
Ground-simulation investigations of VTOL airworthiness criteria for terminal-area operations
Several ground-based simulation experiments undertaken to investigate concerns related to tilt-rotor aircraft airworthiness were conducted. The experiments were conducted on the National Aeronautics and Space Administration (NASA) Ames Research Center's Vertical Motion Simulator, which permits simulation of a wide variety of aircraft with a high degree of fidelity of motion cueing. Variations in conversion/deceleration profile, type of augmentation or automation, level of display assistance, and meteorological conditions were considered in the course of the experiments. Certification pilots from the Federal Aviation Administration (FAA) and the Civil Aviation Authority (CAA) participated, in addition to NASA research pilots. The setup of these experiments on the simulator is summarized, and some of the results highlighted
Influencers and preference predictors of HPV vaccine uptake among US male and female young adult college students
Objective: The purpose of the study was to assess the knowledge, attitudes and beliefs of male and female college students in Kentucky about HPV associated diseases and vaccines, and to determine which parameters predicted self-reported uptake of HPV vaccination. Materials and methods: A self-selected cross-sectional sample of college students completed an evidence-based online survey. Results: Of approximately 1200 potential respondents, 585 completed the survey. The average age was 20.6 (SD 3.15) and 78% were female; 84% of the population had had one or more sexual partners. Concern for HPV vaccine safety and potential need for boosters did not significantly deter vaccine uptake. Likewise, knowledge about HPV associated cancers was not predictive of vaccine uptake. On the other hand, parental influence for vaccination was a strong predictor for vaccine uptake (aOR = 5.32, 2.71–13.03), and free vaccine nearly doubled the likelihood of being vaccinated (aOR 1.90, 1.05–3.41). In addition, the strong preference for the respondent\u27s partner to be HPV vaccinated predicted vaccine uptake (aOR = 4.04, 95% CI: 2.31–7.05), but the lack of preference for partner vaccination predicted an unvaccinated self (aOR = 0.50, 0.27–0.93). Conclusions: HPV vaccination has been successful in young adult college students in Kentucky. Young adults prefer their partners to be HPV vaccinated regardless of whether they themselves are vaccinated. Parental influence and free vaccine were positive predictors for vaccine uptake in this population
Highly efficient visible and near-IR photon pair generation with thin-film lithium niobate
Efficient on-chip entangled photon pair generation at telecom wavelengths is
an integral aspect of emerging quantum optical technologies, particularly for
quantum communication and computing. However, moving to shorter wavelengths
enables the use of more accessible silicon detector technology and opens up
applications in imaging and spectroscopy. Here, we present high brightness
( pairs/mW/nm) visible-near-IR photon pair
generation in a periodically poled lithium niobate nanophotonic waveguide. The
degenerate spectrum of the photon pairs is centered at 811 nm with a bandwidth
of 117 nm. The measured on-chip source efficiency of pairs/mW is on par with source efficiencies at telecom wavelengths and
is also orders of magnitude higher than the efficiencies of other visible
sources implemented in bulk crystal or diffused waveguide-based technologies.
These results represent the shortest wavelength of photon pairs generated in a
nanophotonic waveguide reported to date by nearly an octave.Comment: Main text: 10 pages, 6 figures; Supplementary material: 5 pages, 3
figures. Author initials update
Detection of human papillomavirus in laryngeal squamous cell carcinoma: systematic review and meta-analysis
Background: Recent studies have reported a human papillomavirus (HPV) prevalence of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data on HPV involvement remain largely inconsistent, ascribed by some to differences in HPV detection methods or in geographic origin of the studies.
Objective
To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in LSCC.
Methods
Literature was searched from January 1964 until March 2015. The effect size was calculated as event rates (95% confidence interval [CI]), with homogeneity testing using Cochran's Q and I2 statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size. Potential publication bias was estimated using funnel plot symmetry.
Results
One hundred seventy nine studies were eligible, comprising a sample size of 7,347 LSCCs from different geographic regions. Altogether, 1,830 (25%) cases tested HPV-positive considering all methods, with effect size of 0.269 (95% CI: 0.242 to 0.297; random-effects model). In meta-analysis stratified by the 1) HPV detection technique and 2) geographic study origin, the between-study heterogeneity was significant only for geographic origin (P = .0001). In meta-regression, the HPV detection method (P = .876) or geographic origin (P = .234) were not significant study-level covariates. Some evidence for publication bias was found only for studies from North America and those using non–polymerase chain reaction methods, with a marginal effect on adjusted point estimates for both.
Conclusions
Variability in HPV detection rates in LSCC is explained by geographic origin of study but not by HPV detection method. However, they were not significant study-level covariates in formal meta-regression
Distinct Patterns of Brain Metabolism in Patients at Risk of Sudden Unexpected Death in Epilepsy
Objective: To characterize regional brain metabolic differences in patients at high risk of sudden unexpected death in epilepsy (SUDEP), using fluorine-18-fluorodeoxyglucose positron emission tomography (18FDG-PET). Methods: We studied patients with refractory focal epilepsy at high (n = 56) and low (n = 69) risk of SUDEP who underwent interictal 18FDG-PET as part of their pre-surgical evaluation. Binary SUDEP risk was ascertained by thresholding frequency of focal to bilateral tonic-clonic seizures (FBTCS). A whole brain analysis was employed to explore regional differences in interictal metabolic patterns. We contrasted these findings with regional brain metabolism more directly related to frequency of FBTCS. Results: Regions associated with cardiorespiratory and somatomotor regulation differed in interictal metabolism. In patients at relatively high risk of SUDEP, fluorodeoxyglucose (FDG) uptake was increased in the basal ganglia, ventral diencephalon, midbrain, pons, and deep cerebellar nuclei; uptake was decreased in the left planum temporale. These patterns were distinct from the effect of FBTCS frequency, where increasing frequency was associated with decreased uptake in bilateral medial superior frontal gyri, extending into the left dorsal anterior cingulate cortex. Significance: Regions critical to cardiorespiratory and somatomotor regulation and to recovery from vital challenges show altered interictal metabolic activity in patients with frequent FBTCS considered to be at relatively high-risk of SUDEP, and shed light on the processes that may predispose patients to SUDEP
Vegetation composition, structure and soil properties across coastal forest–barren ecotones
Accepted VersionCoastal barrens support rare plant species but may be threatened by forest encroachment. We determined whether trees spread into coastal barren habitat from forest patches and assessed plant species composition and soil properties across the forest–barren ecotone. We quantified tree age and height, soil properties, and vascular plant, bryophyte and lichen species composition along transects perpendicular to the edges of tree patches within the forest–barren ecotone in coastal Nova Scotia. Randomization tests assessed whether the vegetation and environmental characteristics were significantly different in the transition zone compared to one or both adjoining ecosystems. We used ordination to examine trends in species composition across the ecotone and the relationship to environmental variables. Tree age and height decreased continuously from the forest towards the edge of the forest patches. There were also trends in vegetation composition and structure from the forest into the open barrens. Many species were most abundant within the transition zone, although not always significantly. Soil properties were relatively uniform across the ecotone. The structure and vegetation of the forest–barren ecotone suggests that forest patches act as nuclei for forest expansion on barrens with a typical successional pathway where coastal barren vegetation is gradually replaced by forest species. This encroachment may pose a threat to rare barrens communities. While landscape factors such as salt spray and wind exposure may determine the general locations where forest can establish, biotic processes of growth and dispersal appear to govern the fine-scale expansion of tree patches
The depression in visual impairment trial (DEPVIT): trial design and protocol
<b>Background</b>
The prevalence of depression in people with a visual disability is high but screening for depression and referral for treatment is not yet an integral part of visual rehabilitation service provision. One reason for this may be that there is no good evidence about the effectiveness of treatments in this patient group. This study is the first to evaluate the effect of depression treatments on people with a visual impairment and co morbid depression.<p></p>
<b>Methods/design</b>
The study is an exploratory, multicentre, individually randomised waiting list controlled trial. Participants will be randomised to receive Problem Solving Therapy (PST), a ‘referral to the GP’ requesting treatment according to the NICE’s ‘stepped care’ recommendations or the waiting list arm of the trial. The primary outcome measure is change (from randomisation) in depressive symptoms as measured by the Beck’s Depression Inventory (BDI-II) at 6 months. Secondary outcomes include change in depressive symptoms at 3 months, change in visual function as measured with the near vision subscale of the VFQ-48 and 7 item NEI-VFQ at 3 and 6 months, change in generic health related quality of life (EQ5D), the costs associated with PST, estimates of incremental cost effectiveness, and recruitment rate estimation.<p></p>
<b>Discussion</b>
Depression is prevalent in people with disabling visual impairment. This exploratory study will establish depression screening and referral for treatment in visual rehabilitation clinics in the UK. It will be the first to explore the efficacy of PST and the effectiveness of NICE’s ‘stepped care’ approach to the treatment of depression in people with a visual impairment.<p></p>
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