The Public Interest Inquiry for Permanent Injunctions or Exclusion Orders: Shedding the Myopic Lens

President Obama\u27s 2013 veto of a US International Trade Commission (ITC) exclusion order, issued to address Apple Inc.\u27s infringement of a patent owned by Samsung, thrust the ITC\u27s public interest inquiry into the spotlight. Historically, however, these factors rarely weighed against a remedy at the ITC. Likewise, US district courts have rarely declined to issue a permanent injunction after finding a patent valid and infringed due solely to the public interest factor--the last of the four factors that the Supreme Court put in place in eBay Inc. v. Merc Exchange, L.L.C. More recent decisions addressing the public interest in both forums, however, show a willingness by the adjudicators to weigh both traditional public interest issues, such as health and well-being, and non-traditional arguments, such as public reliance and environmental concerns, against a patent owner\u27s right to exclude. In this Article, we examine some of the successful traditional and non-traditional public interest arguments, both at the ITC and in US district courts. From this analysis, the Article outlines how parties involved in high-stakes patent litigation in either forum can craft public interest arguments to combat the threat of a permanent injunction or an ITC exclusion order

A Compact Five-Channel VLF Wave Receiver for CubeSat Missions

Very low frequency (VLF) waves play an important role in controlling the evolution of energetic electron distributions in near-Earth space. This paper describes the design of a VLF receiver for the Climatology of Anthropogenic and Natural VLF Wave Activity in Space (CANVAS) CubeSat mission, designed to make continuous observations of VLF waves in low-Earth orbit originating from lightning and ground-based transmitters. The CANVAS VLF receiver will observe five components of VLF waves in the 0.3–40 kHz frequency range, using three orthogonal magnetic search coils deployed on the end of a 1-meter carbon fiber boom and four deployable electric field antennas operated as two orthogonal dipoles. Together, these five wave components will be used to calculate real and imaginary spectral matrix components using real-time fast Fourier transforms calculated in an onboard FPGA. Spectral matrix components will be averaged to obtain 1 second time resolution and frequency resolution better than 10%. The averaged spectral matrix will be used to determine the complete set of wave parameters, including Poynting flux, polarization, planarity, and k-vector direction. CANVAS is currently in the manufacturing and assembly phase and is planned to launch at the end of 2022

Topological data analysis approaches to uncovering the timing of ring structure onset in filamentous networks

Improvements in experimental and computational technologies have led to significant increases in data available for analysis. Topological data analysis (TDA) is an emerging area of mathematical research that can identify structures in these data sets. Here we develop a TDA method to detect physical structures in a cell that persist over time. In most cells, protein filaments (actin) interact with motor proteins (myosins) and organize into polymer networks and higher-order structures. An example of these structures are ring channels that maintain constant diameters over time and play key roles in processes such as cell division, development, and wound healing. The interactions of actin with myosin can be challenging to investigate experimentally in living systems, given limitations in filament visualization \textit{in vivo}. We therefore use complex agent-based models that simulate mechanical and chemical interactions of polymer proteins in cells. To understand how filaments organize into structures, we propose a TDA method that assesses effective ring generation in data consisting of simulated actin filament positions through time. We analyze the topological structure of point clouds sampled along these actin filaments and propose an algorithm for connecting significant topological features in time. We introduce visualization tools that allow the detection of dynamic ring structure formation. This method provides a rigorous way to investigate how specific interactions and parameters may impact the timing of filamentous network organization.Comment: 20 pages, 9 figure

EFFECT OF BLOCK DESIGN ON ROTATIONAL CHARACTERISTICS OF A SWIM START

The purpose of this study was to examine the effect of start block design on the rotational characteristics of a swim start. Seven male and seven female university-level competitive swimmers (21.1±2.1 yrs, 1.79±0.08 m, 75.6±11.8 kg) completed three maximal effort swim starts under each of four conditions, flat block with no kick plate, flat block with a kick plate, inclined block with no kick plate and inclined block with a kick plate. Temporal and kinematic variables and angular momentum were determined for each start using a two-dimensional video analysis. Use of an inclined block significantly reduced block time by 4%, reduced time to 5m by 2.2% and reduced vertical velocity at entry by 4.9% compared to a flat block. Use of a kick plate significantly reduced block time by 3.4%, reduced time to 5m by 3.4%, increased horizontal velocity at takeoff by 3.7%, increased horizontal velocity at entry by 2.7% and increased the body orientation angle at takeoff by 2.7% compared to not using a kick plate. Neither block inclination nor use of a kick plate affected airborne whole body angular momentum. These data support using an inclined block platform and kick plate to improve start performance and suggest that experienced swimmers can adapt the rotational characteristics of their start to different conditions

Effect of Block Design on Rotational Characteristics of a Swim Start

Start block design in swimming had received little attention in the literature until the introduction of the kick plate. De Jesus et al. (2022) and Beretic et al. (2012) concluded that use of the kick plate provided advantages primarily in reducing block time and generating greater horizontal takeoff velocity and flight distance. This previous work has not considered how block design may affect the rotational characteristics of a swim start. PURPOSE: The purpose of this study was to examine the effect of start block design on the rotational characteristics of a swim start. METHODS: Fourteen university-level competitive swimmers (21.1±2.1 yrs, 1.79±0.08 m, 75.6±11.8 kg) completed three maximal effort swim starts under each of four conditions, flat block with no kick plate, flat block with a kick plate, inclined block with no kick plate and inclined block with a kick plate. Temporal and kinematic variables and angular momentum were measured for each start using a two-dimensional video analysis. RESULTS: Use of an inclined block significantly (pCONCLUSION: These data support using an inclined block platform and kick plate to improve start performance and suggest that experienced swimmers can adapt the rotational characteristics of their start to different conditions

Lower Extremity Muscle Activity When Walking on a Non-Motorized Treadmill

Effective interventions for increasing walking speed are important for improving health and quality of life in aging populations. Non-motorized treadmills (NMT) may enhance the ability to develop or improve motor control in gait by requiring the participant to produce and maintain speed as compared to use of a motorized treadmill (MT) which requires one to simply match speed. PURPOSE: The purpose of this project was to compare muscle activation patterns of lower extremity muscles between MT, NMT and overground (OG) walking. METHODS: Twenty healthy adults (24.4±7.2 yrs, 1.75±0.09 m, 75.4±13.1 kg) completed one trial of walking at each of three speeds (2.5, 3.5, 4.5 mph) and three modes (OG, MT, NMT). Surface EMG of the Biceps Femoris (BF), Tibialis Anterior (TA), Gastrocnemius (GA), and Vastus Medialis (VM) was collected at 1000 Hz using electrodes placed longitudinally at the midpoint of the muscle belly. After removing DC bias, EMG RMS was computed using a moving window of 250 ms. Peak EMG RMS within a stride was averaged across 8 consecutive gait cycles identified using vertical acceleration measured with a triaxial accelerometer. Separate 3x3 repeated measures ANOVA’s were used to compare muscle activity across walking speed and mode for each muscle. RESULTS: For all muscles, there was no significant interaction between walking mode and speed. Muscle activity significantly increased with walking speed (p\u3c0.05). TA, VM, and GA activity was not different between walking modes (p\u3c0.05). At 2.5 mph, GA muscle activity, was significantly (p\u3c0.001) higher for NMT (0.44±0.16 mV) than MT (0.33±0.13 mV) and OG (0.31±0.14 mV) but MT and OG were not different. At 3.5 mph, GA muscle activity, was significantly (p\u3c0.001) higher for NMT (0.49±0.19 mV) than MT (0.36±0.15 mV) and OG (0.36±0.17 mV) but MT and OG were not different. At 4.5 mph, GA muscle activity, was significantly (p\u3c0.001) higher for NMT (0.58±0.28 mV) than MT (0.47±0.19 mV) and OG (0.44±0.19 mV) but MT and OG were not different. CONCLUSIONS: These data suggest that use of NMT accentuates plantar flexor activity when walking. Given that reduced plantar flexor activity contributes to reduced gait speed in older adults, use of NMT has potential for clinical use in treatment of gait deficiencies in aging adults

In-class cycling to augment college student academic performance and reduce physical inactivity: Results from an RCT

Most college students sit 14 hours per week on average, excluding sedentary study time. Researchers observing workplace and elementary school settings with active workstations to combat sedentary behavior have shown enhanced cognition without distraction. Until now, incorporating active workstations in college classroom settings remained relatively unexplored. This study’s purpose was to assess academic performance using in-class stationary cycle desks during a semester-long lecture course. Twenty-one college students (19–24 years) enrolled in a lecture course volunteered and were split into traditional sit (SIT) and stationary cycle (CYC) groups randomly, matched on a calculated factor equal to a physical activity (PA) score (0–680) multiplied by grade point average (GPA; 4.0 scale). CYC pedaled a prescribed rate of perceived exertion (RPE) of less than 2 out of 10 during a 50-min lecture, 3 × week for 12 weeks. CYC averaged 42 min, 7.9 miles, and 1.7 RPE during class throughout the semester. No significant differences (p \u3e 0.05) were observed between CYC and SIT on in-class test scores or overall course grades. Although statistically insignificant, CYC had higher mean test scores and overall course grades vs. SIT (i.e., B+ vs. B, respectively). Low intensity cycling during a college lecture course maintained student academic performance and possibly reduced weekly sedentary behavior time

Development of a Deltoid Shoulder Muscle Model for Rhesus Monkey Spaceflight Studies

The acromiodeltoid shoulder muscle was demonstrated to be a suitable model for spaceflight studies. The muscle contains a mixture of fast and slow fibers, permitting analysis of muscle fiber type specific changes. Two biopsy sites per muscle were identified that provided samples not degraded by the biopsy procedure. Both sites contained sufficient numbers fibers for determining changes in fiber type percentages and size. There was adequate bilateral symmetry regarding fiber type composition in the left and right muscles such that a total of four times points can be compared. The ESOP cage did not cause atrophy of deltoid muscle fibers; this means that microgravity-induced atrophy should be detectable. As expected, muscle excision stimulated muscle IgM and IgG muscle autoantibody production. Nonrestrained control animals suppressed this response whereas restrained monkeys showed an abnormally pronounced response indicative a compromised immune system. The presence of ESOP cage-induced changes in the immune response may mask spaceflight-induced effects. The ESOP cage modified the dominant hand operation of the PTS. These results demonstrate the importance of high fidelity ground based controls

Parental Support and Adolescents’ Coping with Academic Stressors: A Longitudinal Study of Parents’ Influence Beyond Academic Pressure and Achievement

Adolescents face many academic pressures that require good coping skills, but coping skills can also depend on social resources, such as parental support and fewer negative interactions. The aim of this study was to determine if parental support and parental negative interactions concurrently and longitudinally relate to adolescents’ ways of academic coping, above and beyond the impact of three types of academic stress, students’ achievement at school (i.e., grades in school), and age. Survey data were collected from 839 Australian students in grades 5 to 10 (Mage = 12.2, SD = 1.72; 50% girls). Students completed measures of support and negative interactions with parents; academic stress from workload, external pressure (teachers/parents) to achieve, and intrapsychic pressure for high achievement; and ways of academic coping that were grouped into two positive and two negative types. Hypothesized associations were tested concurrently and from one year to the next using path modeling. Beyond the numerous significant influences of academic stress and achievement on coping, and control for age and COVID-19 timing, adolescents with more parental support reported more use of engagement coping (e.g., strategizing) and comfort-seeking, whereas those who reported more negative interactions with parents reported more use of disengagement coping (e.g., concealment) and escape. In the longitudinal model, parental support predicted an increase in engagement and comfort-seeking and a decrease in disengagement coping, whereas negative interaction with parents predicted an increase in disengagement coping. Overall, the findings support the view that coping with academic stressors will continue to depend on parent-adolescent relationships even into the teen years

Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others. Even monogenic muscular dystrophies selectively affect certain muscle groups. These observations suggest that factors intrinsic to muscle tissues influence their resistance to disease. Nevertheless, most studies have not addressed transcriptional diversity among skeletal muscles. Here we use RNAseq to profile mRNA expression in skeletal, smooth, and cardiac muscle tissues from mice and rats. Our data set, MuscleDB, reveals extensive transcriptional diversity, with greater than 50% of transcripts differentially expressed among skeletal muscle tissues. We detect mRNA expression of hundreds of putative myokines that may underlie the endocrine functions of skeletal muscle. We identify candidate genes that may drive tissue specialization, including Smarca4, Vegfa, and Myostatin. By demonstrating the intrinsic diversity of skeletal muscles, these data provide a resource for studying the mechanisms of tissue specialization