Time Variation of the Broad Hβ and Hα Emission Lines in Active Galactic Nuclei

High-quality Keck/LRIS long-slit spectra for a sample of 97 active galaxies selected from the Sloan Digital Sky Survey (redshift between 0.02 & 0.1; Black Hole Mass approximately 107 Solar Masses) were obtained between January 2009 and March 2010 in order to study the black hole (BH) mass scaling relation in the local universe. Typically, the width of the broad Hβ emission line is used to measure the mass of the black hole (MBH). However, signs of variability in the emission line profile are seen for eight objects: While broad Hβ emission lines had previously been observed in spectra from the Sloan Digital Sky Survey (SDSS), they are missing in the Keck spectra. Based on seeing and PSF profile arguments, we can exclude that the lack of broad lines in the Keck spectra are caused by the telescope being pointed off center, missing the active nucleus. Follow-up observations were conducted in January and March 2013 in both Hβ, as well as Hα (which had not been obtained at Keck) using the Kast spectrograph mounted on the Shane three meter telescope at Lick observatory. Since SDSS uses a 3 arcsec fiber, the position angle of these long-slit observations was set perpendicular to the angle of the Keck longslit observations in order to search for any off-center broad emission. The broad emission lines remain missing in Hβ and are missing or reduced in Hα, suggesting changes in Seyfert classification transitions on timescales of approximately a decade. Observational constraints make variability of the torus or broad-line region over time as the most likely cause for this variation. However, at least in some cases, the existence of an AGN that is non-coincident with the center of the host galaxy due to an ongoing merger or gravitational recoil cannot be ruled out. The most promising candidate for such a scenario is SDSS J10383+4658 which shows a blue knot just off-center from the host galaxy, and could have been missed in Keck observations but is included in the SDSS fiber

Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells.

The goal of anticancer therapy is to selectively eradicate all malignant cells. Unfortunately for the majority of patients with metastatic disease, this goal is consistently thwarted by the nearly inevitable development of therapeutic resistance; the main driver of therapeutic resistance is a minority subpopulation of cancer cells called cancer stem cells (CSCs) whose mitotic quiescence essentially renders them non-eradicable. The Wnt signaling pathway has been widely implicated as a regulator of CSCs and, therefore, its inhibition is thought to result in a reversal of therapeutic resistance via loss of stem cell properties. RRx-001 is a minimally toxic redox-active epi-immunotherapeutic anticancer agent in Phase III clinical trials that sensitizes tumors to radiation and cytotoxic chemotherapies. In this article, as a potential mechanism for its radio- and chemosensitizing activity, we report that RRx-001 targets CD133 + /CD44 + cancer stem cells from three colon cancer cell-lines, HT-29, Caco-2, and HCT116, and inhibits Wnt pathway signalling with downregulation of c-Myc

A Forecast for Large Scale Structure Constraints on Horndeski Gravity with Line Intensity Mapping

We consider the potential for line intensity mapping (LIM) of the rotational CO(1-0), CO(2-1) and CO(3-2) transitions to detect deviations from General Relativity from $0 < z < 3$ within the framework of a very general class of modified gravity models, called Horndeski theories. Our forecast assumes a multi-tracer analysis separately obtaining information from the matter power spectrum and the first two multipoles of the redshift space distortion power spectrum. To achieve $\pm 0.1$ level constraints on the slope of the kinetic gravity braiding and Planck mass evolution parameters, a mm-wave LIM experiment would need to accumulate $\approx 10^8-10^9$ spectrometer hours, feasible with instruments that could be deployed in the 2030s. Such a measurement would constrain large portions of the remaining parameter space available to Scalar-Tensor modified gravity theories. Our modeling code is publicly available.Comment: 13 pages, 5 figures; to be submitted to Monthly Notices of the Royal Astronomical Societ

Three-dimensional range imaging apparatus and method

A three-dimensional range imager includes a light source for providing a modulated light signal, a multiplexer, an optical fiber connecting the light source to the multiplexer, a plurality of optical fibers connected at first ends to the multiplexer and at second ends to a first fiber array, and a transmitter optic disposed adjacent the first fiber array for projecting a pixel pattern of the array onto a target

Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets.

Small-cell lung cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and counterproductive. This report presents the case of a 77-year-old Caucasian male with extensive-stage refractory SCLC who was restarted on platinum doublets as part of a clinical trial called TRIPLE THREAT (NCT02489903) involving pretreatment with the epi-immunotherapeutic agent RRx-001, and who achieved a partial response after only 4 cycles. The patient had received a platinum drug twice before, in 2009 for a diagnosis of non-small-cell lung cancer (squamous cell carcinoma) and in 2015 for SCLC, suggesting that RRx-001 pretreatment may sensitize or resensitize refractory SCLC patients to first-line chemotherapy

Assortative mating but no evidence of genetic divergence in a species characterized by a trophic polymorphism

Disruptive selection is a process that can result in multiple sub-groups within a population, referred to as diversification. Foraging related divergence has been described in many taxa, but many questions remain about the contribution of such divergence to reproductive isolation and potentially sympatric speciation. Here we use stable isotope analysis of diet and morphological analysis of body shape to examine phenotypic divergence between littoral and pelagic foraging ecomorphs in a population of pumpkinseed sunfish (Lepomis gibbosus). We then examine reproductive isolation between ecomorphs by comparing the isotopic compositions of nesting males to eggs from their nests (a proxy for maternal diet), and use nine microsatellite loci to examine genetic divergence between ecomorphs. Our data support the presence of distinct foraging ecomorphs in this population and indicate that there is significant positive assortative mating based on diet. We did not find evidence of genetic divergence between ecomorphs, however, indicating that isolation is either relatively recent or is not strong enough to result in genetic divergence at the microsatellite loci. Based on our findings, pumpkinseed sunfish represent a system in which to further explore the mechanisms by which natural and sexual selection contribute to divergence, prior to the occurrence of sympatric speciation

Radiologic and Histologic Findings of Locally Advanced Mucoepidermoid Carcinoma Managed with Total Surgical Excision

The present case report provides images from computed tomography and histology of a patient with a salivary gland neoplasm consistent with mucoepidermoid carcinoma

The Dilemma of Using Sward Height as a Management Tool for Intensively Grazed Sheep Pasture in Spring

Sward height is often used as a tool for both animal and pasture management, especially when continuously grazing pasture. For example, sward height has been used to define the conditions for optimal feed intake of multiple-bearing ewes, both before and after lambing (Everett-Hincks et al.2005; Morris and Kenyon 2004). Sward height is easily applied by the grazier and so becomes an effective tool. However, changes in the leaf distribution and relative species makeup of the sward both seasonally (Thomson et al. 2001) and in response to grazing management (Webby and Pengelly 1986) mean that the amount of pasture per unit height will change. When these changes occur a dilemma is presented to the grazier. How do they manage the trade-off between a simple indicator for management decisions and the lost opportunity of harvesting pasture mass that may be accumulating below the assigned sward height? This paper presents data from an experiment that investigated the impacts of defoliation strategies on sward of differing starting masses, with defoliation management based on height rather than mass. The paper quantifies the accumulation of herbage below defoliation height and highlights the dilemma of using sward height as a management tool when aiming to maximise the utilisation of our pasture resource