Patagonian herpetology: XII. The iguanids of the Liolaemus fitzingeri group in Chubut: serological data and taxonomic position

Immunological tests and morphological observations are carried out on the polymorphic populations of Liolaemus fitzingeri melanops, from Peninsula Valdés and Puerto Madryn (Chubut). The identity of this form and the sympatric specimens referred to Liolaemus goetschi Müller and Hellmich is supported. The probable active speciation of the fitzingeri complex is pointed out, in accordance with the increasing serological distance between the still recognized subspecific taxa Liolaemus fitzingeri fitzingeri, Liolaemus fitzingeri canqueli and Liolaemus fitzingeri melanops.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Patagonian herpetology: XII. The iguanids of the Liolaemus fitzingeri group in Chubut: serological data and taxonomic position

Immunological tests and morphological observations are carried out on the polymorphic populations of Liolaemus fitzingeri melanops, from Peninsula Valdés and Puerto Madryn (Chubut). The identity of this form and the sympatric specimens referred to Liolaemus goetschi Müller and Hellmich is supported. The probable active speciation of the fitzingeri complex is pointed out, in accordance with the increasing serological distance between the still recognized subspecific taxa Liolaemus fitzingeri fitzingeri, Liolaemus fitzingeri canqueli and Liolaemus fitzingeri melanops.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Patagonian herpetology. XV. Further immunological research on Argentine iguanids of the Liolaemus fitzingeri group

Immunological tests by means of the precipitin reactions support nearby serological relationships between the Liolaemus (fitzingeri) melanops populations from Chubut and the populations belonging to the same morphological group found North of the Colorado River (Argentina). Cross-reactions between samples from Mendoza (Carrizal), San Juan (Bermejo), La Rioja (Baldecitos, Talampaya) provinces and samples from Chubut (Puerto Madryn) emphasize a very high percentage of identical specific antigens. Evolutive trends of this peculiar and widespread group of psammophilous iguanid lizards are briefly analyzed.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Patagonian herpetology. XV. Further immunological research on Argentine iguanids of the Liolaemus fitzingeri group

Immunological tests by means of the precipitin reactions support nearby serological relationships between the Liolaemus (fitzingeri) melanops populations from Chubut and the populations belonging to the same morphological group found North of the Colorado River (Argentina). Cross-reactions between samples from Mendoza (Carrizal), San Juan (Bermejo), La Rioja (Baldecitos, Talampaya) provinces and samples from Chubut (Puerto Madryn) emphasize a very high percentage of identical specific antigens. Evolutive trends of this peculiar and widespread group of psammophilous iguanid lizards are briefly analyzed.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Patagonian herpetology. XV. Further immunological research on Argentine iguanids of the Liolaemus fitzingeri group

Immunological tests by means of the precipitin reactions support nearby serological relationships between the Liolaemus (fitzingeri) melanops populations from Chubut and the populations belonging to the same morphological group found North of the Colorado River (Argentina). Cross-reactions between samples from Mendoza (Carrizal), San Juan (Bermejo), La Rioja (Baldecitos, Talampaya) provinces and samples from Chubut (Puerto Madryn) emphasize a very high percentage of identical specific antigens. Evolutive trends of this peculiar and widespread group of psammophilous iguanid lizards are briefly analyzed.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Patagonian herpetology. XIII. The identity of Liolaemus goetschi with the melanops form of the Liolaemus fitzingeri complex (Rio Negro and Chubut)

The synonymy of Liolaemus goetschi Müller and Hellmich and Liolaemus fitzingeri melanops Burmeister is supported by the serological evidence. Individuals morphologically indistinguishable from Liolaemus goetschi are present in the polymorphic populations of Liolaemus fitzingeri melanops from Puerto Madryn (Chubut). The present biological and evolutionary trends of the fitzingeri complex and its several “incipient species” are analyzed.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Patagonian herpetology. XIII. The identity of Liolaemus goetschi with the melanops form of the Liolaemus fitzingeri complex (Rio Negro and Chubut)

The synonymy of Liolaemus goetschi Müller and Hellmich and Liolaemus fitzingeri melanops Burmeister is supported by the serological evidence. Individuals morphologically indistinguishable from Liolaemus goetschi are present in the polymorphic populations of Liolaemus fitzingeri melanops from Puerto Madryn (Chubut). The present biological and evolutionary trends of the fitzingeri complex and its several “incipient species” are analyzed.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors

The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC cells to PARP inhibitors (PARPi). PDAC cells treated with PARPi stimulated translocation of HuR from the nucleus to the cytoplasm, specifically promoting stabilization of a new target, poly (ADP-ribose) glycohydrolase (PARG) mRNA, by binding a unique sequence embedded in its 30 untranslated region. HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins. Accordingly, strategies to inhibit HuR directly promoted DNA damage accumulation, inefficient PAR removal, and persistent PARP-1 residency on chromatin (PARP-1 trapping). Immunoprecipitation assays demonstrated that the PARP-1 protein binds and posttranslationally modifies HuR in PARPi-treated PDAC cells. In a mouse xenograft model of human PDAC, PARPi monotherapy combined with targeted silencing of HuR significantly reduced tumor growth compared with PARPi therapy alone. Our results highlight the HuR–PARG axis as an opportunity to enhance PARPi-based therapies. ©2017 AACR