CFD Analyses of Textured Surfaces for Tribological Improvements in Hydraulic Pumps

In any hydraulic machine there are lubricated couplings that could become critical beyond certain operating conditions. This paper presents the simulation results concerning textured surfaces with the aim of improving the performance of lubricated couplings in relative motion. The texturing design requires much care to obtain good improvements, and it is essential to analyze both the geometric features of the dimples and the characteristics of the coupled surfaces, like the sliding velocity and gap height. For this purpose, several CFD simulations have been performed to study the behavior of the fluid bounded in the coupling, considering dimples with different shapes, size, and spatial distribution. The simulations consider the onset of gaseous cavitation to evaluate the influence of this phenomenon on the pressure distribution generated by the textured surface. The analyses have pointed out that it is critical to correctly predict the behavior of the textured surface in the presence of local cavitation, in fact, when cavitation occurs, the characteristic time of the transient in which the phase of the fluid change is very rapid and it is comparable to the time taken by the fluid to move from one dimple to the next

Mobile gaming prospects: the challenges to become a serious industry

Mobile games are a main example of both a successful mobile application and the increasing range of platforms for the media and entertainment industries. Against this convergent background, the paper introduces the basic features of the mobile gaming market and its industrial ecosystem with main actors and activities. Its focus lies on the challenges ahead for its evolution into a potentially dominant game platform and on the possible disruptions along this road. The future role of context and the deep personal relationship with the mobile device are considered to further explore mobile games link with users’ perceptions, players’ strategies and pending techno-economic developments

Urinary secretion and extracellular aggregation of mutant uromodulin isoforms.

Uromodulin is exclusively expressed in the thick ascending limb and is the most abundant protein secreted in urine where it is found in high-molecular-weight polymers. Its biological functions are still elusive, but it is thought to play a protective role against urinary tract infection, calcium oxalate crystal formation, and regulation of water and salt balance in the thick ascending limb. Mutations in uromodulin are responsible for autosomal-dominant kidney diseases characterized by defective urine concentrating ability, hyperuricemia, gout, tubulointerstitial fibrosis, renal cysts, and chronic kidney disease. Previous in vitro studies found retention in the endoplasmic reticulum as a common feature of all uromodulin mutant isoforms. Both in vitro and in vivo we found that mutant isoforms partially escaped retention in the endoplasmic reticulum and reached the plasma membrane where they formed large extracellular aggregates that have a dominant-negative effect on coexpressed wild-type protein. Notably, mutant uromodulin excretion was detected in patients carrying uromodulin mutations. Thus, our results suggest that mutant uromodulin exerts a gain-of-function effect that can be exerted by both intra- and extracellular forms of the protein

The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait

BACKGROUND: IgA nephropathy (IgAN) or Berger's disease, is the most common glomerulonephritis in the world diagnosed in renal biopsied patients. The involvement of genetic factors in the pathogenesis of the IgAN is evidenced by ethnic and geographic variations in prevalence, familial clustering in isolated populations, familial aggregation and by the identification of a genetic linkage to locus IGAN1 mapped on 6q22–23. This study seems to imply a single major locus, but the hypothesis of multiple interacting loci or genetic heterogeneity cannot be ruled out. The organization of a multi-centre Biobank for the collection of biological samples and clinical data from IgAN patients and relatives is an important starting point for the identification of the disease susceptibility genes. DESCRIPTION: The IgAN Consortium organized a Biobank, recruiting IgAN patients and relatives following a common protocol. A website was constructed to allow scientific information to be shared between partners and to divulge obtained data (URL: ). The electronic database, the core of the website includes data concerning the subjects enrolled. A search page gives open access to the database and allows groups of patients to be selected according to their clinical characteristics. DNA samples of IgAN patients and relatives belonging to 72 multiplex extended pedigrees were collected. Moreover, 159 trios (sons/daughters affected and healthy parents), 1068 patients with biopsy-proven IgAN and 1040 healthy subjects were included in the IgAN Consortium Biobank. Some valuable and statistically productive genetic studies have been launched within the 5(th )Framework Programme 1998–2002 of the European project No. QLG1-2000-00464 and preliminary data have been published in "Technology Marketplace" website: . CONCLUSION: The first world IgAN Biobank with a readily accessible database has been constituted. The knowledge gained from the study of Mendelian diseases has shown that the genetic dissection of a complex trait is more powerful when combined linkage-based, association-based, and sequence-based approaches are performed. This Biobank continuously expanded contains a sample size of adequately matched IgAN patients and healthy subjects, extended multiplex pedigrees, parent-child trios, thus permitting the combined genetic approaches with collaborative studies