Adult Pancreatoblastoma - Case Report and Review of Literature

Most cases of pancreatoblastoma, a rare malignant epithelial tumor of the pancreas, are seen in the pediatric population. The rarity of pancreatoblastoma, the similar radiologic findings to those seen in other pancreatic lesions, and its histopathologic heterogeneity, make its preoperative diagnosis in adults a real challenge. We report ultrasound, computed tomography and magnetic resonance imaging correlative findings of a histologically proven pancreatoblastoma in a 37-year-old woman. Pancreatoblastoma should be considered in the differential diagnosis of a pancreatic mass presenting uncommon imaging features.info:eu-repo/semantics/publishedVersio

Molecular imaging of hypoxia with radiolabelled agents

Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant progression. This has led to the development of assays for the detection of hypoxia in patients in order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments. A variety of invasive and non-invasive approaches have been developed to measure tumour oxygenation including oxygen-sensitive electrodes and hypoxia marker techniques using various labels that can be detected by different methods such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), autoradiography and immunohistochemistry. This review aims to give a detailed overview of non-invasive molecular imaging modalities with radiolabelled PET and SPECT tracers that are available to measure tumour hypoxia

Spunti per una riconsiderazione del principio canonistico ex nudo pacto oritur actio

L'autore propone nuovi spunti interpretativi del principio canonistico "ex nudo pacto oritur actio" alla luce di una rilettura delle fonti classiche. Si individuano, quindi, i fondamenti dell'efficacia dell'obbligazione da promessa analizzando da un lato i temi della ratio peccati e della ratio scandali, dall'altro gli strumenti di tutela processuale della denunciatio evangelica e dell'imploratio officii iudicis volti a garantire l'efficacia stessa della promessa

L'ECONOMIA DELLA PROMESSA NELLO SVOLGIMENTO DELLE OBBLIGAZIONI IN DIRITTO CANONICO. IL CONTRIBUTO DELLA SECONDA SCOLASTICA ALLO SVILUPPO DEL MODERNO CONCETTO DI NEGOZIO GIURIDICO

The present thesis of Doctorate of Research introduces a critical study of the modern discussion on the promise obligation, according to the theological-juridical contract docrine of the late scolastics in the sixteenth and seventeenth centuries, and of his contribution to the development of the modern concept of "juristic act". The analysis of treatises "De iustitia et iure" has demonstrated the promissory economy (essence) of contracts and of similary figures and the varied normative efficacy of promises that are binding as a means of exercise of moral virtue of commutative justice, liberality, promise-keeping ("fidelitas"), "amicitia"

Perylene-bisimide (PBI) metal complexes as stabilizers of carbon nanotubes mixtures for temperature sensing

It has been observed that perylene-bisimide (PBI) derivatives can show interesting properties concerning biosubstrates binding and non-canonical nucleic acids forms stabilization. Moreover, they find use in new materials as stabilizers for carbon nanotubes and temperature sensors. Therefore, it seemed to be of some interest, to perform a study of the metal complexation ability of a newly synthesised ligand, where the central perylene core (chromophore) is connected to two crown-ether residues. Absorbance titrations were analysed, also by means of the HypSpec2014® software, to shed light on the ligand affinity toward Ca2+, Ni2+, Co2+, Fe3+, Pb2+ metal ions and on the stoichiometry of complexes eventually formed. Nickel and cobalt do form the 1:1 complex and not quantitatively. In the case of Ca2+, Fe3+ and Pb2+ the 1:1 ML complex can be quantitatively formed, even if other stoichiometries are possible. The 1:1 Pery-Crown5/Ca, Pery-Crown5/Fe, Pery-Crown5/Pb complexes (together with Pery-Crown5 alone for comparison purposes) were then added to multi-walled carbon nanotubes (MWCNTs) mixtures. The stabilizing ability of the metal complexes towards MWCNTs was quantitatively measured by means of thermal analysis (TGA).The deposition of MWCNT/Pery-Crown5 dispersions on plastic film supporting gold electrodes allowed the fabrication of temperature sensors, whose response was checked. The results obtained are promising and give interesting information on possible modulation and optimisation of the use of metal complexes in MWCNTs-based sensors

Preparation of viable adult ventricular myocardial slices from large and small mammals.

This protocol describes the preparation of highly viable adult ventricular myocardial slices from the hearts of small and large mammals, including rodents, pigs, dogs and humans. Adult ventricular myocardial slices are 100- to 400-μm-thick slices of living myocardium that retain the native multicellularity, architecture and physiology of the heart. This protocol provides a list of the equipment and reagents required alongside a detailed description of the methodology for heart explantation, tissue preparation, slicing with a vibratome and handling of myocardial slices. Supplementary videos are included to visually demonstrate these steps. A number of critical steps are addressed that must be followed in order to prepare highly viable myocardial slices. These include identification of myocardial fiber direction and fiber alignment within the tissue block, careful temperature control, use of an excitation-contraction uncoupler, optimal vibratome settings and correct handling of myocardial slices. Many aspects of cardiac structure and function can be studied using myocardial slices in vitro. Typical results obtained with hearts from a small mammal (rat) and a large mammal (human) with heart failure are shown, demonstrating myocardial slice viability, maximum contractility, Ca2+ handling and structure. This protocol can be completed in ∼4 h