29 research outputs found
Verlauf und Therapie des idiopathischen Parkinson-Syndroms bei Patienten der Klinik und Poliklinik fĂŒr Neurologie des UniversitĂ€tsklinikums Köln
Ziel der Studie war es, mit Hilfe einer groĂen Kohorte Trends und etablierte Methoden der Therapie des Morbus Parkinson zu analysieren und mit Ergebnissen der internationalen Literatur zu vergleichen.
DafĂŒr wurden Daten von 365 Parkinson-Patienten der UniversitĂ€tsklinik Köln retrospektiv erfasst und ausgewertet.
Die Daten umfassten demographische Angaben wie Alter, Geschlecht und Erkrankungsdauer sowie Parameter zu Medikation, motorischem Zustand und neuropsychologischen Tests.
Der Verlauf der Krankheitsparameter wurde dann in Bezug auf den Einsatz der Tiefen Hirnstimulation ĂŒberprĂŒft und dargestellt.
Die Ergebnisse unserer Studie waren in vielen Bereichen im Einklang mit der aktuellen Datenlage international veröffentlichter Studien, wobei unsere Studie jedoch im Vergleich zu vielen anderen der angefĂŒhrten Studien eine globale Sicht auf verschiedene Parameter der Parkinson-Krankheit ermöglichte.
Die Tiefe Hirnstimulation fĂŒhrte bei unseren Patienten zu einer signifikanten Verminderung der Parkinson-Medikation, sowie zu einer Verbesserung der Motorik in den ersten Jahren nach deren Einsatz und einer fraglich positiven Modifikation des Krankheitsverlaufs.
Weiterhin konnten Aussagen zum Alter der Patienten, Krankheitsdauer, Geschlechtsunterschieden, Stimulationszielgebieten und Krankheitssubtypen bezogen auf die Tiefe Hirnstimulation gemacht werden.
Aufbauend auf unserer Studie sind weitere longitudinale prospektive Studien sinnvoll und interessant, um die gefundenen Ergebnisse zu ĂŒberprĂŒfen und ein tieferes VerstĂ€ndnis fĂŒr eine verbesserte Therapie des Morbus Parkinson zu schaffen
Photoinduced host-to-guest electron transfer in a self-assembled coordination cage
A [Pd2L4] coordination cage, assembled from electron-rich phenothiazine-based ligands and encapsulating an electron-deficient anthraquinone-based disulfonate guest, is reported. Upon excitation at 400 nm, transient absorption spectroscopy unveils photoinduced electron transfer from the host's chromophores to the guest, as indicated by characteristic spectral features assigned to the oxidized donor and reduced acceptor. The structure of the hostâguest complex was characterized by NMR spectroscopy, mass spectrometry and single-crystal X-ray analysis. Spectroelectrochemical experiments and DFT calculations both agree with the proposed light-induced charge separation. A kinetic analysis of the involved charge transfer channels reveals, besides a guest-independent LMCT path, 44% efficiency for the hostâguest charge transfer (HGCT)
Liver transplantation reverses hypergammaglobulinemia in patients with chronic hepatic failure
Introduction: Sparse data are available about the effect of therapy methods on antibody levels in patients with liver failure. The aim of this study was to determine serum immunoglobulin concentrations in patients with chronic hepatic failure (CHF), acute- (ALF), or acute-on-chronic liver failure (ACLF) and to evaluate the impact of MARS treatment or liver transplantation (LT) on antibody levels.
Materials and methods: We followed ten patients with ALF, twelve with ACLF and 18 with CHF. Eight patients with ALF and seven with ACLF underwent MARS therapy, whereas the rest received LT. 13 healthy volunteers served as controls. Serum antibody concentrations were measured using ELISA-technique.
Results: Median serum levels of IgA, IgG and IgM were significantly increased in patients with CHF compared to ALF or controls (P < 0.02, P < 0.01, and P < 0.01). IgM and IgG concentrations were also significantly elevated in patients with CHF compared to ACLF (IgM, 3.7 vs. 1 g/L, P < 0.001; IgG, 8.7 vs. 3.1 g/L, P = 0.004). Immediately after LT a significant decrease of IgA (6.9 vs. 3.1 g/L, P = 0.004), IgG (8.7 vs. 5.1 g/L, P = 0.02) and IgM (3.7 vs. 1.8 g/L, P = 0.001) was detected in patients with CHF and antibody levels further decreased the days after LT reaching levels comparable to healthy individuals. MARS treatment had no apparent effect on the immunoglobulin profile in patients with ALF or ACLF.
Conclusion: We provide evidence that LT reverses hypergammaglobulinemia in patients suffering from CHF within one day, which could be explained to a reconstituted hepatic antibody clearance, whereas MARS treatment has no immediate effect on immunoglobulin levels
The European Anorectal Malformation Network (ARM-Net) patient registry:10-year review of clinical and surgical characteristics
Femtosecond UV-pump mid-IR probe spectroscopy of the ultrafast photodissociation of azide radicals from an azidoiron(III) complex
The ultrafast photolysis of the cation complex [(cyclam-ac)FeN3]+ is studied by femtosecond spectroscopy with ultraviolet excitation and mid-infrared probing. Immediately after UV absorption, the excited complex undergoes internal conversion and azide dissociation within 2 ps. The subsequent vibrational relaxation in the electronic ground state and geminate recombination of the fragments take place on time scales of 13 and 20 ps, respectively
Dose-Response-Relationship between Number of Laser Burns and IOP Reduction in Cyclophotocoagulation: An Animal Study
Purpose. The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect. Methods. 30 chinchilla bastard rabbits were divided into 5 groups and treated with either 1, 5, 10, 20, or 30 CPC burns, respectively. IOP was followed up for 1 week. IOP reduction of a single 30-burn treatment was compared with a fractionated treatment (three sessions; one week in between; 10 burns/session). Results. IOP reduction increases nonlinearly with the number of CPC burns (max. -6.1±1.4âmmHg). Fractionated treatment shows similar IOP reduction with less complications and more constant results compared to single session treatment. Conclusions. The study reveals a complex relationship between IOP reduction and the number of CPC burns. Fractionated CPC gives comparable IOP reduction at a higher degree of safety
Photoinduced host-to-guest electron transfer in a self-assembled coordination cage
A [PdL] coordination cage, assembled from electron-rich phenothiazine-based ligands and encapsulating an electron-deficient anthraquinone-based disulfonate guest, is reported. Upon excitation at 400 nm, transient absorption spectroscopy unveils photoinduced electron transfer from the host's chromophores to the guest, as indicated by characteristic spectral features assigned to the oxidized donor and reduced acceptor. The structure of the hostâguest complex was characterized by NMR spectroscopy, mass spectrometry and single-crystal X-ray analysis. Spectroelectrochemical experiments and DFT calculations both agree with the proposed light-induced charge separation. A kinetic analysis of the involved charge transfer channels reveals, besides a guest-independent LMCT path, 44% efficiency for the hostâguest charge transfer (HGCT)
The Photochemical Route to Octahedral Iron(V). Primary Processes and Quantum Yields from Ultrafast Mid-Infrared Spectroscopy
Recently, the complex cation [(cyclam-ac)ÂFe<sup>III</sup>(N<sub>3</sub>)]<sup>+</sup> has been used in solid matrices
under cryogenic
conditions as a photochemical precursor for an octahedral iron nitride
containing the metal at the remarkably high oxidation state +5. Here,
we study the photochemical primary events of this complex cation in
liquid solution at room temperature using femtosecond time-resolved
mid-infrared (fs-MIR) spectroscopy as well as step-scan Fourier-transform
infrared spectroscopy, both of which were carried out with variable-wavelength
excitation. In stark contrast to the cryomatrix experiments, a photooxidized
product cannot be detected in liquid solution when the complex is
excited through its putative LMCT band in the visible region. Instead,
only a redox-neutral dissociation of azide anions is seen under these
conditions. However, clear evidence is found for the formation of
the highly oxidized iron nitride product when the photolysis is carried
out in liquid solution with UV light. Yet, the photooxidation must
compete with photoreductive FeâN bond cleavage leading to azide
radicals and an ironÂ(II) complex. Both, redox-neutral and photoreductive
FeâN bond breakage as well as photooxidative NâN bond
breakage occur on a time scale well below a few hundred femtoseconds.
The majority of fragments suffer from geminate recombination back
to the parent complex on a time scale of 10 ps. Upper limits of the
primary quantum yield for photooxidation are derived from the fs-MIR
data, which increase with increasing energy of the photolysis photon