Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique

Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogram-based noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolution-limited vasculature independent of vessel orientation and flow velocity

UV and IR behaviour in QFT and LCQFT with fields as Operator Valued Distributions:Epstein and Glaser revisited

Following Epstein-Glaser's work we show how a QFT formulation based on operator valued distributions (OPVD) with adequate test functions treats original singularities of propagators on the diagonal in a mathematically rigourous way.Thereby UV and/or IR divergences are avoided at any stage, only a finite renormalization finally occurs at a point related to the arbitrary scale present in the test functions.Some well known UV cases are examplified.The power of the IR treatment is shown for the free massive scalar field theory developed in the (conventionally hopeless) mass perturbation expansion.It is argued that the approach should prove most useful for non pertubative methods where the usual determination of counterterms is elusiveComment: 6 pages 2 columns per pag

Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography

We present high-speed Fourier-domain optical coherence tomography (Fd-OCT) with the phase variance based motion contrast method for visualizing retinal micro-circulation in vivo. This technique allows non-invasive visualization of a two-dimensional retinal perfusion map and concurrent volumetric morphology of retinal microvasculature with high sensitivity. The high-speed acquisition rate at 125kHz A-scans enables reduction of motion artifacts with increased scanning area if compared to previously reported results. Several scanning schemes with different sampling densities and scanning areas are evaluated to find optimal parameters for in vivo imaging. In order to evaluate this technique, we compare OCT micro-capillary imaging using the phase variance technique with fundus fluorescein angiography (FA). Additionally, volumetric visualization of blood flow for a normal subject is presented

Protostars and Outflows in the NGC7538 - IRS9 Cloud Core

New high resolution observations of HCO+ J=1-0, H13CN J=1-0, SO 2,2 - 1,1, and continuum with BIMA at 3.4 mm show that the NGC7538 - IRS9 cloud core is a site of active ongoing star formation. Our observations reveal at least three young bipolar molecular outflows, all ~ 10,000 -- 20,000 years old. IRS9 drives a bipolar, extreme high velocity outflow observed nearly pole on. South of IRS9 we find a cold, protostellar condensation with a size of ~ 14" x 6" with a mass > 250 Msun. This is the center of one of the outflows and shows deep, red-shifted self absorption in HCO+, suggesting that there is a protostar embedded in the core, still in a phase of active accretion. This source is not detected in the far infrared, suggesting that the luminosity < 10^4 Lsun; yet the mass of the outflow is ~ 60 Msun. The red-shifted HCO+ self-absorption profiles observed toward the southern protostar and IRS9 predict accretion rates of a few times 10^-4 to 10^-3 Msun/yr. Deep VLA continuum observations at 3.6 cm show that IRS9 coincides with a faint thermal VLA source, but no other young star in the IRS9 region has any detectable free-free emission at a level of ~ 60 microJy at 3.6 cm. The HCO+ abundance is significantly enhanced in the hot IRS9 outflow. A direct comparison of mass estimates from HCO+ and CO for the well-characterized red-shifted IRS9 outflow predicts an HCO+ enhancement of more than a factor of 30, or [HCO+/H2] >= 6 10^-8.Comment: 40 pages, 3 tables and 10 figures included; to appear in Ap

The heats of formation of the haloacetylenes XCCY [X, Y = H, F, Cl]: basis set limit ab initio results and thermochemical analysis

The heats of formation of haloacetylenes are evaluated using the recent W1 and W2 ab initio computational thermochemistry methods. These calculations involve CCSD and CCSD(T) coupled cluster methods, basis sets of up to spdfgh quality, extrapolations to the one-particle basis set limit, and contributions of inner-shell correlation, scalar relativistic effects, and (where relevant) first-order spin-orbit coupling. The heats of formation determined using W2 theory are: \hof(HCCH) = 54.48 kcal/mol, \hof(HCCF) = 25.15 kcal/mol, \hof(FCCF) = 1.38 kcal/mol, \hof(HCCCl) = 54.83 kcal/mol, \hof(ClCCCl) = 56.21 kcal/mol, and \hof(FCCCl) = 28.47 kcal/mol. Enthalpies of hydrogenation and destabilization energies relative to acetylene were obtained at the W1 level of theory. So doing we find the following destabilization order for acetylenes: FCCF $>$ ClCCF $>$ HCCF $>$ ClCCCl $>$ HCCCl $>$ HCCH. By a combination of W1 theory and isodesmic reactions, we show that the generally accepted heat of formation of 1,2-dichloroethane should be revised to -31.8$\pm$0.6 kcal/mol, in excellent agreement with a very recent critically evaluated review. The performance of compound thermochemistry schemes such as G2, G3, G3X and CBS-QB3 theories has been analyzed.Comment: Mol. Phys., in press (E. R. Davidson issue

Optical imaging of the chorioretinal vasculature in the living human eye

Detailed visualization of microvascular changes in the human retina is clinically limited by the capabilities of angiography imaging, a 2D fundus photograph that requires an intravenous injection of fluorescent dye. Whereas current angiography methods enable visualization of some retinal capillary detail, they do not adequately reveal the choriocapillaris or other microvascular features beneath the retina. We have developed a noninvasive microvascular imaging technique called phase-variance optical coherence tomography (pvOCT), which identifies vasculature three dimensionally through analysis of data acquired with OCT systems. The pvOCT imaging method is not only capable of generating capillary perfusion maps for the retina, but it can also use the 3D capabilities to segment the data in depth to isolate vasculature in different layers of the retina and choroid. This paper demonstrates some of the capabilities of pvOCT imaging of the anterior layers of choroidal vasculature of a healthy normal eye as well as of eyes with geographic atrophy (GA) secondary to age-related macular degeneration. The pvOCT data presented permit digital segmentation to produce 2D depth-resolved images of the retinal vasculature, the choriocapillaris, and the vessels in Sattler’s and Haller’s layers. Comparisons are presented between en face projections of pvOCT data within the superficial choroid and clinical angiography images for regions of GA. Abnormalities and vascular dropout observed within the choriocapillaris for pvOCT are compared with regional GA progression. The capability of pvOCT imaging of the microvasculature of the choriocapillaris and the anterior choroidal vasculature has the potential to become a unique tool to evaluate therapies and understand the underlying mechanisms of age-related macular degeneration progression

The NASA/IPAC Teacher Archive Research Program (NITARP)

NITARP, the NASA/IPAC Teacher Archive Research Program, partners small groups of largely high school educators with research astronomers for a year-long research project. This paper presents a summary of how NITARP works. Because NITARP has been running since 2009, and its predecessor ran from 2005-2008, there have been many lessons learned over the last 13 years, some of which are also discussed here. The most important of these include the following. Scientists must see their work with the educators on their team as a partnership of equals. Educators must be reminded often that they will not have command of all the information needed during their NITARP year, and that it is ok to ask lots of questions. NITARP teams need to be about 5 people: a mentor astronomer, a mentor teacher (who has been through the program before), and 3 new educators; larger or smaller teams just don’t work as well. Teams need to communicate regularly and frequently through their year

Earthquake Size Distribution: Power-Law with Exponent Beta = 1/2?

We propose that the widely observed and universal Gutenberg-Richter relation is a mathematical consequence of the critical branching nature of earthquake process in a brittle fracture environment. These arguments, though preliminary, are confirmed by recent investigations of the seismic moment distribution in global earthquake catalogs and by the results on the distribution in crystals of dislocation avalanche sizes. We consider possible systematic and random errors in determining earthquake size, especially its seismic moment. These effects increase the estimate of the parameter beta of the power-law distribution of earthquake sizes. In particular, we find that estimated beta-values may be inflated by 1-3% because relative moment uncertainties decrease with increasing earthquake size. Moreover, earthquake clustering greatly influences the beta-parameter. If clusters (aftershock sequences) are taken as the entity to be studied, then the exponent value for their size distribution would decrease by 5-10%. The complexity of any earthquake source also inflates the estimated beta-value by at least 3-7%. The centroid depth distribution also should influence the beta-value, an approximate calculation suggests that the exponent value may be increased by 2-6%. Taking all these effects into account, we propose that the recently obtained beta-value of 0.63 could be reduced to about 0.52--0.56: near the universal constant value (1/2) predicted by theoretical arguments. We also consider possible consequences of the universal beta-value and its relevance for theoretical and practical understanding of earthquake occurrence in various tectonic and Earth structure environments. Using comparative crystal deformation results may help us understand the generation of seismic tremors and slow earthquakes and illuminate the transition from brittle fracture to plastic flow.Comment: 46 pages, 2 tables, 11 figures 53 pages, 2 tables, 12 figure

The NASA/IPAC Teacher Archive Research Program (NITARP)

NITARP, the NASA/IPAC Teacher Archive Research Program, partners small groups of predominantly high school educators with research astronomers for a year-long research project. This paper presents a summary of how NITARP works and the lessons learned over the last 13 years. The program lasts a calendar year, January to January, and involves three ~week-long trips: to the American Astronomical Society (AAS) winter meeting, to Caltech in the summer (with students), and back to a winter AAS meeting (with students) to present their results. Because NITARP has been running since 2009, and its predecessor ran from 2005-2008, there have been many lessons learned over the last 13 years that have informed the development of the program. The most critical is that scientists must see their work with the educators on their team as a partnership of equals who have specialized in different professions. NITARP teams appear to function most efficiently with approximately 5 people: a mentor astronomer, a mentor teacher (who has been through the program before), and 3 new educators. Educators are asked to step into the role of learner and develop their question-asking skills as they work to develop an understanding of a subject in which they will not have command of all the information and processes needed. Critical to the success of each team is the development of communication skills and fluid plan of action to keep the lines of communication open. This program has allowed more than 100 educators to present more than 60 total science posters at the AAS.Comment: Accepted by refereed conference proceedings for RTSRE 201