TE Wave Measurement and Modeling

In the TE wave method, microwaves are coupled into the beam-pipe and the effect of the electron cloud on these microwaves is measured. An electron cloud (EC) density can then be calculated from this measurement. There are two analysis methods currently in use. The first treats the microwaves as being transmitted from one point to another in the accelerator. The second more recent method, treats the beam-pipe as a resonant cavity. This paper will summarize the reasons for adopting the resonant TE wave analysis as well as give examples from CESRTA and DA{\Phi}NE of resonant beam-pipe. The results of bead-pull bench measurements will show some possible standing wave patterns, including a cutoff mode (evanescent) where the field decreases exponentially with distance from the drive point. We will outline other recent developments in the TE wave method including VORPAL simulations of microwave resonances, as well as the simulation of transmission in the presence of both an electron cloud and magnetic fields.Comment: Presented at ECLOUD'12: Joint INFN-CERN-EuCARD-AccNet Workshop on Electron-Cloud Effects, La Biodola, Isola d'Elba, Italy, 5-9 June 2012; CERN-2013-002, pp. 193-20

Establishment of a mini-advanced technology development center

Issued as Quarterly reports no. [1-3] and Final report, Project no. L-30-802 (subproject is B-558/P.D. Loveless

Continuation of the mini-technology development center program in Barrow, Madison, and Jackson counties

Issued as Quarterly reports, nos. 1-3, and Final reports, nos. 1-2, Project no. L-30-812(subproject is B-562

Services within a busy period of an M/M/1 queue and Dyck paths

We analyze the service times of customers in a stable M/M/1 queue in equilibrium depending on their position in a busy period. We give the law of the service of a customer at the beginning, at the end, or in the middle of the busy period. It enables as a by-product to prove that the process of instants of beginning of services is not Poisson. We then proceed to a more precise analysis. We consider a family of polynomial generating series associated with Dyck paths of length 2n and we show that they provide the correlation function of the successive services in a busy period with (n+1) customers

On Writ of Certiorari to the United States Court of Appeals for the Ninth Circuit, Brief of Product Liability Advisory Council, Inc., National Association of Manufacturers, Business Roundtable, and Chemical Manufacturers Association as Amici Curiae in Support of Respondent, William Daubert and Joyce Daubert, Individually and as Guardians Ad Litem for Jason Daubert, and Anita De Young, Individually and as Gaurdian Ad Litem for Eric Schuller v. Merrell Dow Pharmaceuticals, Inc.

The Federal Rules of Evidence exclude expert scientific testimony when it has been developed without regard for accepted scientific methods. This case focuses on expert scientific evidence. Such evidence plays a vital and often dispositive role in modern litigation. For scientific evidence to be helpful to the factfinder it must meet some minimal threshold of reliability. To hold otherwise would be to allow a system of adjudication based more on chance than on reason

Soil profile method for soil thermal diffusivity, conductivity and heat flux: Comparison to soil heat flux plates

Diffusive heat flux at the soil surface is commonly determined as a mean value over a time period using heat flux plates buried at some depth (e.g., 5–8 cm) below the surface with a correction to surface flux based on the change in heat storage during the corresponding time period in the soil layer above the plates. The change in heat storage is based on the soil temperature change in the layer over the time period and an estimate of the soil thermal heat capacity that is based on soil water content, bulk density and organic matter content. One- or multiple-layer corrections using some measure of mean soil temperature over the layer depth are common; and in some cases the soil water content has been determined, although rarely. Several problems with the heat flux plate method limit the accuracy of soil heat flux values. An alternative method is presented and this flux gradient method is compared with soil heat flux plate measurements. The method is based on periodic (e.g., half-hourly) water content and temperature sensing at multiple depths within the soil profile and a solution of the Fourier heat flux equation. A Fourier sine series is fit to the temperature at each depth and the temperature at the next depth below is simulated with a sine series solution of the differential heat flux equation using successive approximation of the best fit based on changing the thermal diffusivity value. The best fit thermal diffusivity value is converted to a thermal conductivity value using the soil heat capacity, which is based on the measured water content and bulk density. A statistical analysis of the many data resulting from repeated application of this method is applied to describe the thermal conductivity as a function of water content and bulk density. The soil heat flux between each pair of temperature measurement depths is computed using the thermal conductivity function and measured water contents. The thermal gradient method of heat flux calculation compared well to values determined using heat flux plates and calorimetric correction to the soil surface; and it provided better representation of the surface spatiotemporal variation of heat flux and more accurate heat flux values. The overall method resulted in additional important knowledge including the water content dynamics in the near-surface soil profile and a soil-specific function relating thermal conductivity to soil water content and bulk density

Haemogenic endocardium contributes to transient definitive haematopoiesis.

Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic lineages, it remains unknown whether the mammalian heart tube serves as a haemogenic organ akin to the dorsal aorta. Here we examine the haemogenic activity of the developing endocardium. Mouse heart explants generate myeloid and erythroid colonies in the absence of circulation. Haemogenic activity arises from a subset of endocardial cells in the outflow cushion and atria earlier than in the aorta-gonad-mesonephros region, and is transient and definitive in nature. Interestingly, key cardiac transcription factors, Nkx2-5 and Isl1, are expressed in and required for the haemogenic population of the endocardium. Together, these data suggest that a subset of endocardial/endothelial cells serve as a de novo source for transient definitive haematopoietic progenitors

Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells

SummaryRemoval of TRF2, a telomere shelterin protein, recapitulates key aspects of telomere attrition including the DNA-damage response and cell-cycle arrest [1]. Distinct from the response of proliferating cells to loss of TRF2 [2, 3], in rodent noncycling cells, TRF2 inhibition promotes differentiation and growth [4, 5]. However, the mechanism that couples telomere gene-silencing features [6–8] to differentiation programs has yet to be elucidated. Here we describe an extratelomeric function of TRF2 in the regulation of neuronal genes mediated by the interaction of TRF2 with repressor element 1-silencing transcription factor (REST), a master repressor of gene networks devoted to neuronal functions [9–12]. TRF2-REST complexes are readily detected by coimmunoprecipitation assays and are localized to aggregated PML-nuclear bodies in undifferentiated pluripotent human NTera2 stem cells. Inhibition of TRF2, either by a dominant-negative mutant or by RNA interference, dissociates TRF2-REST complexes resulting in ubiquitin-proteasomal degradation of REST. Consequentially, REST-targeted neural genes (L1CAM, β3-tubulin, synaptophysin, and others) are derepressed, resulting in acquisition of neuronal phenotypes. Notably, selective damage to telomeres without affecting TRF2 levels causes neither REST degradation nor cell differentiation. Thus, in addition to protecting telomeres, TRF2 possesses a novel role in stabilization of REST thereby controlling neural tumor and stem cell fate