Mapping Indigenous education participation

Schwab and Sutherland (forthcoming) present a spatial analysis of the distribution of Indigenous education participation across Australia. Amongst their main findings is the marked effect of geographic isolation on participation. We extend this analysis by relating other Indigenous and non-Indigenous outcomes to the educational participation of 15–19 year olds via a regression framework, estimated at the geographic level. We find that access to schools and other institutions is indeed associated with educational participation. However, other factors are also important; these are variables that act as a proxy for disruption within Indigenous households, access to electronic resources that support educational participation in the home, and the presence of the CDEP scheme. In the paper we also compare the remoteness category of a student’s usual residence on census night with their remoteness category of five years beforehand. We find that, amongst other things, although Indigenous students who lived in remote or very remote areas five years beforehand are more likely to have moved than the general population (especially university students), a substantial number still remain in these areas. This has important implications for the provision of distance and online learning

Measuring and analysing success for Aboriginal and Torres Strait Islander Australians

The Closing the Gap targets feature heavily in the current policy measurement framework for Aboriginal and Torres Strait Islander Australians at both the national and state/territory levels. The targets provide concrete measures against which trends in changes in outcomes for the Indigenous population relative to those for the non-Indigenous population can be assessed. Although relative outcomes for the Indigenous population have improved for some of the targets, overall there has been a failure to achieve virtually all of the targets. There are also concerns that the Closing the Gap measures are resulting in an overly negative assessment of progress in improving outcomes for Indigenous Australians, and that they entrench a ‘deficits’ view of the Indigenous population. The aim of this paper is to provide helpful information to consider when assessing alternative frameworks for measuring and targeting success. We consider how to define success for Indigenous individuals, families and communities; what are the key determinants of success for Indigenous Australians; what are some of the areas of success within the seven target areas and more broadly; and what are the implications for frameworks for measuring success

The Future of Blood Testing Is the Immunome

It is increasingly clear that an extraordinarily diverse range of clinically important conditions-including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers-leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person's B cells (antibodies) and T cells. We refer to these as the immunome. Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test. Here we discuss some of these opportunities, the current state of immunome-based diagnostics, and highlight some of the challenges involved. We conclude with a call to clinicians, researchers, and others to join efforts with the Adaptive Immune Receptor Repertoire Community (AIRR-C) to realize the diagnostic potential of the immunome

Whatcom County Adult Correction Facilities Environmental Impact Statement

Whatcom County is concerned with the current poor conditions of its adult correctional facilities and has proposed to construct a new facility. The new facility is proposed to hold up to 2,450 beds by 2050. For operational purposes, a horizontally designed facility is preferred

Can gold be an effective catalyst for the Deacon reaction?

The Deacon reaction is an important industrial process for the oxidation of hydrogen chloride, thereby enabling chlorine to be recycled. As gold is an efficient catalyst for reactions involving hydrogen chloride and oxygen, we have studied the use of gold as a potential catalyst for the Deacon reaction. Unfortunately, gold displays only limited activity; however, this is markedly increased if hydrogen is cofed as a reactant

Persistent starspot signals on M dwarfs: multi-wavelength Doppler observations with the Habitable-zone Planet Finder and Keck/HIRES

Young, rapidly-rotating M dwarfs exhibit prominent starspots, which create quasiperiodic signals in their photometric and Doppler spectroscopic measurements. The periodic Doppler signals can mimic radial velocity (RV) changes expected from orbiting exoplanets. Exoplanets can be distinguished from activity-induced false positives by the chromaticity and long-term incoherence of starspot signals, but these qualities are poorly constrained for fully-convective M stars. Coherent photometric starspot signals on M dwarfs may persist for hundreds of rotations, and the wavelength dependence of starspot RV signals may not be consistent between stars due to differences in their magnetic fields and active regions. We obtained precise multi-wavelength RVs of four rapidly-rotating M dwarfs (AD Leo, G 227-22, GJ 1245B, GJ 3959) using the near-infrared (NIR) Habitable-zone Planet Finder, and the optical Keck/HIRES spectrometer. Our RVs are complemented by photometry from Kepler, TESS, and the Las Cumbres Observatory (LCO) network of telescopes. We found that all four stars exhibit large spot-induced Doppler signals at their rotation periods, and investigated the longevity and optical-to-NIR chromaticity for these signals. The phase curves remain coherent much longer than is typical for Sunlike stars. Their chromaticity varies, and one star (GJ 3959) exhibits optical and NIR RV modulation consistent in both phase and amplitude. In general, though, we find that the NIR amplitudes are lower than their optical counterparts. We conclude that starspot modulation for rapidly-rotating M stars frequently remains coherent for hundreds of stellar rotations, and gives rise to Doppler signals that, due to this coherence, may be mistaken for exoplanets.Comment: Accepted for publication in the Astrophysical Journa

A Methodology for Successful University Graduate CubeSat Programs

The University of Colorado Smead Department of Aerospace Engineering has over a decade of success in designing, building, and operating student led CubeSat missions. The experience and lessons learned from building and operating the CSSWE, MinXSS-1, MinXSS-2, and QB50-Challenger missions have helped grow a knowledge base on the most effective and efficient ways to manage some of the “tall poles” when it comes to student run CubeSat missions. Among these “tall poles” we have seen student turnover, software, and documentation become some of the hardest to knock-down and we present our strategies for doing so. We use the MAXWELL mission (expected to launch in 2021) as a road-map to detail the methodology we have built over the last decade to ensure the greatest chance of mission success

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells

Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative disorders, but the exact mechanisms and causal connections are not clear and most previous work was done in neurons and not in microglial cells. Here, we report that exogenous fibrillary, but not monomeric, alpha-synuclein (AS, also known as SNCA) induces autophagy in microglial cells. We extensively studied the dynamics of this response using both live-cell imaging and correlative light-electron microscopy (CLEM), and found that it correlates with lysosomal damage and is characterised by the recruitment of the selective autophagy-associated proteins TANK-binding kinase 1 (TBK1) and optineurin (OPTN) to ubiquitylated lysosomes. In addition, we observed that LC3 (MAP1LC3B) recruitment to damaged lysosomes was dependent on TBK1 activity. In these fibrillar AS-treated cells, autophagy inhibition impairs mitochondrial function and leads to microglial cell death. Our results suggest that microglial autophagy is induced in response to lysosomal damage caused by persistent accumulation of AS fibrils. Importantly, triggering of the autophagic response appears to be an attempt at lysosomal quality control and not for engulfment of fibrillar AS.Fil: Bussi, Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Peralta Ramos, Javier María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Arroyo, Daniela Soledad. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gallea, Jose Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Ronchi, Paolo. European Molecular Biology Laboratory; AlemaniaFil: Kolovou, Androniki. European Molecular Biology Laboratory; AlemaniaFil: Wang, Ji M.. National Cancer Institute at Frederick; Estados UnidosFil: Florey, Oliver. Babraham Institute; Reino UnidoFil: Celej, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Schwab, Yannick. European Molecular Biology Laboratory; AlemaniaFil: Ktistakis, Nicholas. Babraham Institute; Reino UnidoFil: Iribarren, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; Argentin

Science Hybrid Orbiter and Lunar Relay (SCHOLR) Architecture and Design

Considered both a stepping-stone to deep space and a key to unlocking the mysteries of planetary formation, the Moon offers a unique opportunity for scientific study. Robotic precursor missions are being developed to improve technology and enable new approaches to exploration. Robots, lunar landers, and satellites play significant roles in advancing science and technologies, offering close range and in-situ observations. Science and exploration data gathered from these nodes and a lunar science satellite is intended to support future human expeditions and facilitate future utilization of lunar resources. To attain a global view of lunar science, the nodes will be distributed over the lunar surface, including locations on the far side of the Moon. Given that nodes on the lunar far side do not have direct line-of-sight for Earth communications, the planned presence of such nodes creates the need for a lunar communications relay satellite. Since the communications relay capability would only be required for a small portion of the satellite s orbit, it may be possible to include communication relay components on a science spacecraft. Furthermore, an integrated satellite has the potential to reduce lunar surface mission costs. A SCience Hybrid Orbiter and Lunar Relay (SCHOLR) is proposed to accomplish scientific goals while also supporting the communications needs of landers on the far side of the Moon. User needs and design drivers for the system were derived from the anticipated needs of future robotic and lander missions. Based on these drivers and user requirements, accommodations for communications payload aboard a science spacecraft were developed. A team of interns identified and compared possible SCHOLR architectures. The final SCHOLR architecture was analyzed in terms of orbiter lifetime, lunar surface coverage, size, mass, power, and communications data rates. This paper presents the driving requirements, operational concept, and architecture views for SCHOLR within a lunar surface nodal network. Orbital and bidirectional link analysis, between lunar nodes, orbiter, and Earth, as well as a conceptual design for the spacecraft are also presente

DNA-bridging by an archaeal histone variant via a unique tetramerisation interface

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into 'hypernucleosome' particles of varying sizes with each dimer wrapping 30 bp of DNA. These are composed of canonical and variant histone paralogues, but the function of these variants is poorly understood. Here, we characterise the structure and function of the histone paralogue MJ1647 from Methanocaldococcus jannaschii that has a unique C-terminal extension enabling homotetramerisation. The 1.9 Å X-ray structure of a dimeric MJ1647 species, structural modelling of the tetramer, and site-directed mutagenesis reveal that the C-terminal tetramerization module consists of two alpha helices in a handshake arrangement. Unlike canonical histones, MJ1647 tetramers can bridge two DNA molecules in vitro. Using single-molecule tethered particle motion and DNA binding assays, we show that MJ1647 tetramers bind ~60 bp DNA and compact DNA in a highly cooperative manner. We furthermore show that MJ1647 effectively competes with the transcription machinery to block access to the promoter in vitro. To the best of our knowledge, MJ1647 is the first histone shown to have DNA bridging properties, which has important implications for genome structure and gene expression in archaea