6 research outputs found
PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma
- Author
- Beuers U. (Ulrich)
- Biermann K. (Katharina)
- Boor P.P.C. (Patrick)
- Bruno M.J. (Marco)
- Buschow S.I. (Sonja I.)
- Gulik T.M. (Thomas) van
- Hansen B.E. (Bettina)
- IJzermans J.N.M. (Jan)
- Kwekkeboom J. (Jaap)
- Man R.A. (Robert) de
- Mancham S. (Shanta)
- Pan Q. (Qiuwei)
- Schutz H.M. (Hannah M.)
- Sideras K. (Kostandinos)
- Sleijfer S. (Stefan)
- Sprengers D. (Dave)
- Takkenberg B.R. (Bart R.)
- Terkivatan T. (TĂŒrkan)
- Verheij J. (Joanne)
- Verseput M.C.M. (Maddy C. M.)
- Publication venue
- 'Informa UK Limited'
- Publication date
- 10/02/2017
- Field of study
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses. Understanding the mechanisms of immune resistance by HCC is crucial for development of suitable immunotherapeutics. We used immunohistochemistry on tissue-microarrays to examine the co-expression of the immune inhibiting molecules PD-L1, Galectin-9, HVEM and IDO, as well as tumor CD8+ lymphocyte infiltration in HCC, in two independent cohorts of patients. We found that at least some expression in tumor cells was seen in 97% of cases for HVEM, 83% for PD-L1, 79% for Gal-9 and 66% for IDO. In the discovery cohort (n = 94), we found that lack of, or low, tumor expression of PD-L1 (p < 0.001), Galectin-9 (p < 0.001) and HVEM (p < 0.001), and low CD8+TIL count (p = 0.016), were associated with poor HCC-specific survival. PD-L1, Galectin-9 and CD8+TIL count were predictive of HCC-specific survival independent of baseline clinicopathologic characteristics and the combination of these markers was a powerful predictor of HCC-specific survival (HR 0.29; p <0.001). These results were confirmed in the validation cohort (n = 60). We show that low expression levels of PD-L1 and Gal-9 in combination with low CD8+TIL count predict extremely poor HCC-specific survival and it requires a change in two of these parameters to significantly improve prognosis. In conclusion, intra-tumoral expression of these immune inhibiting molecules was observed in the majority of HCC patients. Low expression of PD-L1 and Galectin-9 and low CD8+TIL count are associated with poor HCC-specific survival. Combining immune biomarkers leads to superior predictors of HCC mortality
Direct observation of the dead-cone effect in quantum chromodynamics
- Author
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- Yoon J.H.
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- Yoon Jin Hee
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- Zbroszczyk Hanna Paulina
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- Zhalov M.
- Zhalov Mikhail
- Zhang S.
- Zhang S.
- Zhang Song
- Zhang X.
- Zhang X.
- Zhang Xiaoming
- Zhang Y.
- Zhang Y.
- Zhang Yifei
- Zherebchevskii V.
- Zherebchevskii V.
- Zherebchevskii Vladimir
- Zhi Y.
- Zhi Y.
- Zhigareva N.
- Zhigareva N.
- Zhigareva Natalia
- Zhou D.
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- Zhou Daicui
- Zhou Y.
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- Zhou You
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- Zhu Jianhui
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- Ć afaĆĂk K.
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- Ć erkĆĄnytÄ L.
- Ć erkĆĄnytÄ L.
- Ć umbera M.
- Ć umbera M.
- Publication venue
- Publication date
- 10/06/2021
- Field of study
At particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD) [1]. The vacuum is not transparent to the partons and induces gluon radiation and quark pair production in a process that can be described as a parton shower [2]. Studying the pattern of the parton shower is one of the key experimental tools in understanding the properties of QCD. This pattern is expected to depend on the mass of the initiating parton, through a phenomenon known as the dead-cone effect, which predicts a suppression of the gluon spectrum emitted by a heavy quark of mass m and energy E, within a cone of angular size m/E around the emitter [3]. A direct observation of the dead-cone effect in QCD has not been possible until now, due to the challenge of reconstructing the cascading quarks and gluons from the experimentally accessible bound hadronic states. Here we show the first direct observation of the QCD dead-cone by using new iterative declustering techniques [4, 5] to reconstruct the parton shower of charm quarks. This result confirms a fundamental feature of QCD, which is derived more generally from its origin as a gauge quantum field theory. Furthermore, the measurement of a dead-cone angle constitutes the first direct experimental observation of the non-zero mass of the charm quark, which is a fundamental constant in the standard model of particle physics.The direct measurement of the QCD dead cone in charm quark fragmentation is reported, using iterative declustering of jets tagged with a fully reconstructed charmed hadron.In particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD). These partons subsequently emit further partons in a process that can be described as a parton shower which culminates in the formation of detectable hadrons. Studying the pattern of the parton shower is one of the key experimental tools for testing QCD. This pattern is expected to depend on the mass of the initiating parton, through a phenomenon known as the dead-cone effect, which predicts a suppression of the gluon spectrum emitted by a heavy quark of mass mQâ and energy E, within a cone of angular size mQâ/E around the emitter. Previously, a direct observation of the dead-cone effect in QCD had not been possible, owing to the challenge of reconstructing the cascading quarks and gluons from the experimentally accessible hadrons. We report the direct observation of the QCD dead cone by using new iterative declustering techniques to reconstruct the parton shower of charm quarks. This result confirms a fundamental feature of QCD. Furthermore, the measurement of a dead-cone angle constitutes a direct experimental observation of the non-zero mass of the charm quark, which is a fundamental constant in the standard model of particle physics
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Angelova Svetoslava V.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Arun Kg G.
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Atallah Dany V.
- Aufmuth Peter
- Aulbert Carsten
- Aultoneal K.
- Austin Corey
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barkett Kevin
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
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- Bayley Joseph C.
- Bazzan Marco
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- Berger Beverly K.
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- Berry Christopher P.L.
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- Wipf Christopher C.
- Wittel Holger
- Woan Graham
- Woehler Janis
- Wofford Jared
- Wong K.W.K.
- Worden John
- Wright Jennifer L.
- Wu David S.
- Wysocki Daniel M.
- Xiao Sophia
- Yamamoto Hiro
- Yancey Cregg C.
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- Yap M.J.
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- Yu Hang
- Yu Haocun
- Yvert Michel
- ZadroĆŒny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Sylvia J.
- Zhu Xingjiang J.
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceSpinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11Â pulsars using data from Advanced LIGOâs first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far
First low-frequency Einstein@Home all-sky search for continuous gravitational waves in Advanced LIGO data
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Altin Paul A.
- Amato A.
- Ananyeva Alena
- Anderson D.P.
- Anderson Stuart B.
- Anderson Warren G.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Aufmuth Peter
- Aulbert Carsten
- Aultoneal K.
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
- Bartos Imre
- Bassiri Riccardo
- Basti Andrea
- Batch James C.
- Baune Christoph
- Bawaj M.
- Bazzan Marco
- Beer Christian
- Bejger Michal
- Belahcene Imene
- Bell Angus S.
- Berger Beverly K.
- Bergmann Gerald
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Bhagwat Swetha
- Bhandare Rohan
- Bilenko Igor A.
- Billingsley Garilynn
- Billman Chris R.
- Birch Jeremy
- Birney Ross
- Birnholtz Ofek
- Biscans Sebastien
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- Westphal Tobias
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- Willke Benno
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- Winkler Walter
- Wipf Christopher C.
- Wittel Holger
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- Worden John
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- ZadroĆŒny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Sylvia J.
- Zhu Xingjiang J.
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceWe report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the first Advanced LIGO observing run. This search investigates the low frequency range of Advanced LIGO data, between 20 and 100Â Hz, much of which was not explored in initial LIGO. The search was made possible by the computing power provided by the volunteers of the Einstein@Home project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population, corresponding to a sensitivity depth of 48.7ââ[1/Hz]. At the frequency of best strain sensitivity, near 100Â Hz, we set 90% confidence upper limits of 1.8Ă10-25. At the low end of our frequency range, 20Â Hz, we achieve upper limits of 3.9Ă10-24. At 55Â Hz we can exclude sources with ellipticities greater than 10-5 within 100Â pc of Earth with fiducial value of the principal moment of inertia of 1038ââkgâm2
Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Almoubayyed Husni
- Altin Paul A.
- Amato A.
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Arun Kg G.
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Aufmuth Peter
- Aulbert Carsten
- AultONeal K.
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
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- Bassiri Riccardo
- Basti Andrea
- Batch James C.
- Baune Christoph
- Bawaj M.
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- Beer Christian
- Bejger Michal
- Belahcene Imene
- Bell Angus S.
- Berger Beverly K.
- Bergmann Gerald
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Bhagwat Swetha
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- Billingsley Garilynn
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- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Xingjiang
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceDuring their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass 100ââMâ, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than 0.93ââGpcâ3âyrâ1 in comoving units at the 90%Â confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits
Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo
- Author
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adhikari Naresh
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Agarwal Deepali
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Ajith P.
- Akutsu Tomotada
- Albanesi Simone
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Anand Chandana
- Anand Shreya
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Ando Masaki
- Andrade Tomas
- Andres Nicolas
- AndriÄ Tomislav
- Angelova Svetoslava V.
- Ansoldi Stefano
- Antelis J.M.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Arai Koya
- Arai Yuya
- Araki Sakae
- Araya Akito
- Araya Melody C.
- Areeda Joseph S.
- Arellano Fabian E. Peña
- Aritomi Naoki
- Arnaud Nicolas
- Aronson Scott M.
- Arun Kg G.
- ArĂšne Marc
- Asada Hideki
- Asali Yasmeen
- Ashton Gregory
- Aso Yoichi
- Assiduo Maria
- Aston Stuart M.
- Astone Pia
- Aubin Florian
- Austin Corey
- Babak Stanislav
- Badaracco Francesca
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- Badger Charles
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- Bajastani L.M. Daneshgaran
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- Wilson Dalziel J.
- Winkler Walter
- Wipf Christopher C.
- Wlodarczyk Tom
- Woan Graham
- Woehler Janis
- Wofford Jared K.
- Wong I.C. F.
- Wu C.
- Wu David S.
- Wu H.
- Wu S.
- Wysocki Daniel M.
- Xiao Liting
- Xu W-R.
- Yamada Tomohiro
- Yamamoto Hiro
- Yamamoto Kazuhiro
- Yamamoto Kohei
- Yamamoto Takahiro
- Yamashita Kanta
- Yamazaki Ryo
- Yang Fengwei W.
- Yang Le
- Yang Yang
- Yang Yi
- Yang Ziyan
- Yap M.J.
- Yeeles David W.
- Yelikar Anjali B.
- Ying Make
- Yokogawa Kazuya
- Yokoyama J.
- Yokozawa Takaaki
- Yoo Jooheon
- Yoshioka Toshiya
- Yu Hang
- Yu Haocun
- Yuzurihara Hirotaka
- ZadroĆŒny Adam
- Zanolin Michele
- Zeidler Simon
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhan Mingsheng
- Zhang Hong
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhang Yanqi
- Zhao Chunnong
- Zhao Guoying
- Zhao Yue
- Zhao Yuhang
- Zhou Ruinan
- Zhou Zifan
- Zhu Xingjiang J.
- Zhu Z.-H.
- Zimmerman Aaron B.
- Zlochower Y.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'EDP Sciences'
- Publication date
- 01/01/2022
- Field of study
International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100â105âMâ, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass âŒ150âMâ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200âMâ and effective aligned spin 0.8 at 0.056 Gpcâ3 yrâ1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpcâ3 yrâ1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]â Deceased, August 2020