Rupture of the Uterus in a Bitch

On Jan. 25, 1959, a two and one half year-old female boxer was admitted to the Stange Memorial Clinic. The history given by the client was that the dog had whelped shortly after Christmas, 1958, with no noticeable complications. The dog seemed normal until 10 days before she was brought to \u27the clinic for examination. The first symptoms noticed by the owner were bloating and abdominal distention. The \u27bloating became continuously worse. Other symptoms shown were partial anorexia, swollen labia, vulvar discharge, and a temperature of 102.8° F. Urination and defecation were reported to be normal and the dog had not vomited

The Portrayal of the German in Russian Novels - Gončarov, Turgenev, Dostoevskij, Tolstoj

It is the intention of this dissertation to investigate, as thoroughly as possible, the portrayal of the German as he appears in the prose works (drama and poetry have been excluded) of four of Russia's greatest nineteenth-century literary writers- I. A, Gončarov, I. S. Turgenev, F. M. Dostoevskij, and L. N. Tolstoj

Endorsement of the CONSORT Statement by high impact factor medical journals: a survey of journal editors and journal 'Instructions to Authors'

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.

The CONSORT statement is used worldwide to improve the reporting of randomised controlled trials. Kenneth Schulz and colleagues describe the latest version, CONSORT 2010, which updates the reporting guideline based on new methodological evidence and accumulating experience. To encourage dissemination of the CONSORT 2010 Statement, this article is freely accessible on www.ijph.it

Probing Wolf-Rayet Winds: Chandra/HETG X-Ray Spectra of WR 6

With a deep Chandra/HETGS exposure of WR 6, we have resolved emission lines whose profiles show that the X-rays originate from a uniformly expanding spherical wind of high X-ray-continuum optical depth. The presence of strong helium-like forbidden lines places the source of X-ray emission at tens to hundreds of stellar radii from the photosphere. Variability was present in X-rays and simultaneous optical photometry, but neither were correlated with the known period of the system or with each other. An enhanced abundance of sodium revealed nuclear processed material, a quantity related to the evolutionary state of the star. The characterization of the extent and nature of the hot plasma in WR 6 will help to pave the way to a more fundamental theoretical understanding of the winds and evolution of massive stars.Comment: Accepted by the Astrophysical Journa

MicroRNAs in Ewing's Sarcoma

Les tumeurs de la famille du sarcome d'Ewing (ESFTs) sont les deuxièmes plus fréquentes formes de cancer de l'os chez l'enfant et l'adolescent. Le gène de fusion EWS-FLI1 est associé à 85-90% des ESFTs. Ce cancer a probablement pour origine des cellules souches mésenchymateuses (MSCs). Il a en effet été démontré que les MSCs pédiatriques (hpMSCs) sont particulièrement permissives pour le gène de fusion EWS-FLI1 et que celui-ci induit des gènes de cellules souches embryonnaires. Ceci génère une sous-population de cellules présentant des caractéristiques de cellules souches cancéreuses de sarcome d'Ewing (ESFT CSCs) in vitro. Ces cellules reprogrammées n'ont pas de potentiel tumorigénique et un certain nombre de microARN ne sont pas réprimés ou exprimés comme dans un sarcome d'Ewing primaire et sa sous-population de CSCs. Parmi ces microARN on trouve en particulier les membres de la famille let-7 qui jouent un rôle clé dans le contrôle de l'état de différenciation des cellules et régulent de nombreux oncogènes. De plus, leur répression serait capable de favoriser la tumorigénèse. Tous les membres de la famille des microARNs let-7 ont un régulateur commun, la protéine lin-28, qui exerce notamment son action en bloquant la maturation de ces microARNs. Dans ce travail, il s'agira d'évaluer si la co-expression de EWS-FLI1 et de lin-28 dans des hpMSCs permet de créer une sous-population de cellules présentant les caractéristiques de ESFT CSCs. Nous évaluerons l'effet de lin-28 sur les membres de la famille des let7 dans les hpMSCs et apprécierons le potentiel tumorigénique in vivo des hpMSCs exprimant EWS-FLI1 et lin-28. L'outil « Targetscan » est un logiciel qui permet de prédire les cibles des microARN en analysant leur séquence et en la comparant à l'ARN messager 3' non transcrit. Pour les microARN de la famille des let-7, cet outil identifie des gènes cibles potentiels qui jouent un rôle important dans le sarcome d'Ewing. Nous évaluerons si ces protéines sont en effet régulées de façon let-7 dépendante et les conséquences sur la pathogénèse des ESFTs

Update on the endorsement of CONSORT by high impact factor journals: a survey of journal

The CONsolidated Standards Of Reporting Trials (CONSORT) Statement provides a minimum standard set of items to be reported in published clinical trials; it has received widespread recognition within the biomedical publishing community. This research aims to provide an update on the endorsement of CONSORT by high impact medical journals.We performed a cross-sectional examination of the onlin

The reporting of methods for reducing and detecting bias: an example from the WHO Misoprostol Third Stage of Labour equivalence randomised controlled trial

BACKGROUND: The aim of this article is to explore ways in which selection bias and ascertainment bias can be reduced and investigated in trials, by using the example of a drug trial carried out in both developed and developing countries in hospital delivery wards. METHODS: We describe an innovative and practical design for the boxes for packing the drugs as a way of increasing the security of allocation concealment and blinding. We also assess ascertainment bias using sensitivity analyses, as some unblinding could have occurred due to a potential side effect of one of the drugs. RESULTS: The sensitivity analyses indicated that the conclusions about the relative effects of the treatments could be maintained even in the unlikely worst-case scenarios. CONCLUSIONS: Detailed description of the procedures protecting against common biases and of the assessment of ascertainment bias in this trial should allow readers to confidently appraise and interpret the results obtained. In addition, our experiences will assist others in planning trials in the future