SPIRE Point Source Catalog Explanatory Supplement

The Spectral and Photometric Imaging Receiver (SPIRE) was launched as one of the scientific instruments on board of the space observatory Herschel. The SPIRE photometer opened up an entirely new window in the Submillimeter domain for large scale mapping, that up to then was very difficult to observe. There are already several catalogs that were produced by individual Herschel science projects. Yet, we estimate that the objects of only a fraction of these maps will ever be systematically extracted and published by the science teams that originally proposed the observations. The SPIRE instrument performed its standard photometric observations in an optically very stable configuration, only moving the telescope across the sky, with variations in its configuration parameters limited to scan speed and sampling rate. This and the scarcity of features in the data that require special processing steps made this dataset very attractive for producing an expert reduced catalog of point sources that is being described in this document. The Catalog was extracted from a total of 6878 unmodified SPIRE scan map observations. The photometry was obtained by a systematic and homogeneous source extraction procedure, followed by a rigorous quality check that emphasized reliability over completeness. Having to exclude regions affected by strong Galactic emission, that pushed the limits of the four source extraction methods that were used, this catalog is aimed primarily at the extragalactic community. The result can serve as a pathfinder for ALMA and other Submillimeter and Far-Infrared facilities. 1,693,718 sources are included in the final catalog, splitting into 950688, 524734, 218296 objects for the 250\mu m, 350\mu m, and 500\mu m bands, respectively. The catalog comes with well characterized environments, reliability, completeness, and accuracies, that single programs typically cannot provide

Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes

Little is known about the mechanism of prediabetes-induced cardiac dysfunction. Therefore, we aimed to explore key molecular changes with transcriptomic and bioinformatics approaches in a prediabetes model showing heart failure with preserved ejection fraction phenotype. To induce prediabetes, Long-Evans rats were fed a high-fat diet for 21 weeks and treated with a single low-dose streptozotocin at week 4. Small RNA-sequencing, in silico microRNA (miRNA)-mRNA target prediction, Gene Ontology analysis, and target validation with qRT-PCR were performed in left ventricle samples. From the miRBase-annotated 752 mature miRNA sequences expression of 356 miRNAs was detectable. We identified two upregulated and three downregulated miRNAs in the prediabetic group. We predicted 445 mRNA targets of the five differentially expressed miRNAs and selected 11 mRNAs targeted by three differentially expressed miRNAs, out of which five mRNAs were selected for validation. Out of these five targets, downregulation of three mRNAs i.e., Juxtaposed with another zinc finger protein 1 (Jazf1); RAP2C, member of RAS oncogene family (Rap2c); and Zinc finger with KRAB and SCAN domains 1 (Zkscan1) were validated. This is the first demonstration that prediabetes alters cardiac miRNA expression profile. Predicted targets of differentially expressed miRNAs include Jazf1, Zkscan1, and Rap2c mRNAs. These transcriptomic changes may contribute to the diastolic dysfunction and may serve as drug targets

Módosított GnRH-III-antraciklin biokonjugátumok daganat növekedést gátló hatásának tanulmányozása in vivo szubkután vs. ortotopikus rendszerekben

Az irányított/célzott tumorterápia nagyon perspektivikus eljárás a daganatok szelektív elpusztítására, ezáltal kiküszöbölhetők, vagy visszaszoríthatók a tumorellenes gyógyszerek mellékhatásai. Erre az eljárásra használhatók olyan konjugátumok, ahol a tumorellenes szer irányító molekulához (pl. peptid hormonok) van kapcsolva, melyeknek receptorai szelektíven csak a daganatsejteken jelennek meg, vagy azokon jóval nagyobb mennyiségben fordulnak elő, mint az egészséges sejteken. Az in vitro citosztázis/citotoxicitás vizsgálatok általában nem nyújtanak elég információt arra nézve, hogy az előállított konjugátum hatékonyabb-e a szabad hatóanyagnál, erre csak az in vivo vizsgálatokból lehet következtetni. Nagyon fontos azonban a hamis pozitív eredmények kiszűrése érdekében a megfelelő tumormodell megválasztása. Munkánk során egy gonadotropin-releasing hormon analóg a GnRH-III variánsok daunorubicin konjugátumainak daganatnövekedést gátló hatását vizsgáltuk egerekbe szubkután, illetve ortotopikusan beültetett tumorokon. A környezetétől izolált szubkután tumormodell a valóságtól eltérő eredményeket adhat a molekulák tumornövekedést gátló hatásának vizsgálatára. Az ortotopikus rendszerrel jobban modellezhető az anatómiailag és klinikailag megfelelő állapot. Ezért célszerű a későbbiekben az általunk kialakított ortotopikus vastagbél tumormodellt alkalmazni az irányított daganatterápiára előállított vegyületek szűrésére

The phase diagram of magnetic ladders constructed from a composite-spin model

White's density matrix renormalization group ({DMRG}) method has been applied to an $S= 1/2 + 1/2$ composite-spin model, which can also be considered as a two-leg ladder model. By appropriate choices of the coupling constants this model allows not only to study how the gap is opened around the gapless integrable models, but also to interpolate continuously between models with different spin lengths. We have found indications for the existence of several different massive phases.Comment: 30 pages, 8 Postscript figure

Total Aortic Arch Replacement: Superior Ventriculo-Arterial Coupling with Decellularized Allografts Compared with Conventional Prostheses.

BACKGROUND: To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement. This study investigated ventriculoarterial coupling and vascular impedance after replacement of the aortic arch with conventional prostheses vs. decellularized allografts. METHODS: After preparing decellularized aortic arch allografts, their mechanical, histological and biochemical properties were evaluated and compared to native aortic arches and conventional prostheses in vitro. In open-chest dogs, total aortic arch replacement was performed with conventional prostheses and compared to decellularized allografts (n = 5/group). Aortic flow and pressure were recorded continuously, left ventricular pressure-volume relations were measured by using a pressure-conductance catheter. From the hemodynamic variables end-systolic elastance (Ees), arterial elastance (Ea) and ventriculoarterial coupling were calculated. Characteristic impedance (Z) was assessed by Fourier analysis. RESULTS: While Ees did not differ between the groups and over time (4.1+/-1.19 vs. 4.58+/-1.39 mmHg/mL and 3.21+/-0.97 vs. 3.96+/-1.16 mmHg/mL), Ea showed a higher increase in the prosthesis group (4.01+/-0.67 vs. 6.18+/-0.20 mmHg/mL, P<0.05) in comparison to decellularized allografts (5.03+/-0.35 vs. 5.99+/-1.09 mmHg/mL). This led to impaired ventriculoarterial coupling in the prosthesis group, while it remained unchanged in the allograft group (62.5+/-50.9 vs. 3.9+/-23.4%). Z showed a strong increasing tendency in the prosthesis group and it was markedly higher after replacement when compared to decellularized allografts (44.6+/-8.3dyn.sec.cm-5 vs. 32.4+/-2.0dyn.sec.cm-5, P<0.05). CONCLUSIONS: Total aortic arch replacement leads to contractility-afterload mismatch by means of increased impedance and invert ventriculoarterial coupling ratio after implantation of conventional prostheses. Implantation of decellularized allografts preserves vascular impedance thereby improving ventriculoarterial mechanoenergetics after aortic arch replacement