Eastern Airlines: The Rise and Fall of The Wings of Man

This paper examines the rise and fall of Eastern Airlines from 1928 to 1991. lt outlines the carrier\u27s development under a succession of leaders and discusses the major events of each leader\u27s reign. From a small contract mail carrier known as Pitcairn Aviation, Eastern grew to become one of the largest airlines in the free world. But after 26 years of growth and prosperity under the leadership of Eddie Rickenbacker, the airline began to stumble in the early 1960s. Frank Lorenzo took the reins in 1986 and began selling the carrier\u27s assets while attempting to destroy the unions. After a massive employee strike in 1989 and a bout with bankruptcy, Eastern stopped flying in January 1991

Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors

The chemical diversity of nature has tremendous potential for discovery of new molecular probes and medicinal agents. However, sensitivity of HTS assays to interfering components of crude extracts derived from plants, macro- and microorganisms has curtailed their use in lead discovery efforts. Here we describe a process for leveraging the concentration-response curves (CRCs) obtained from quantitative HTS to improve the initial selection of “actives” from a library of partially fractionated natural product extracts derived from marine actinomycetes and fungi. By using pharmacological activity, the first-pass CRC paradigm aims to improve the probability that labor-intensive subsequent steps of re-culturing, extraction and bioassay-guided isolation of active component(s) target the most promising strains and growth conditions. We illustrate how this process identified a family of fungal metabolites as potent inhibitors of firefly luciferase, subsequently resolved in molecular detail by x-ray crystallography

Development of the X-ray camera for the OGRE sub-orbital rocket

Current theories regarding the matter composition of the universe suggest that half of the expected baryonic matter is missing. One region this could be residing in is intergalactic filaments which absorb strongly in the X-ray regime. Present space based technology is limited when it comes to imaging at these wavelengths and so new techniques are required. The Off-Plane Grating Rocket Experiment (OGRE) aims to produce the highest resolution spectrum of the binary star system Capella, a well-known X-ray source, in the soft X-ray range (0.2keV to 2keV). This will be achieved using a specialised payload combining three low technology readiness level components placed on-board a sub-orbital rocket. These three components consist of an array of large format off-plane X-ray diffraction gratings, a Wolter Type 1 mirror made using single crystal silicon, and the use of EM-CCDs to capture soft X-rays. Each of these components have been previously reviewed with OGRE being the first project to utilise them in a space observation mission. This paper focuses on the EM-CCDs (CCD207-40 by e2v) that will be used and their optimisation with a camera purposely designed for OGRE. Electron Multiplying gain curves were produced for the back-illuminated devices at -80 degrees Celsius. Further tests which will need to be carried out are discussed and the impact of the OGRE mission on future projects mentioned

Epicardial adipose excision slows the progression of porcine coronary atherosclerosis

BACKGROUND: In humans there is a positive association between epicardial adipose tissue (EAT) volume and coronary atherosclerosis (CAD) burden. We tested the hypothesis that EAT contributes locally to CAD in a pig model. METHODS: Ossabaw miniature swine (n = 9) were fed an atherogenic diet for 6 months to produce CAD. A 15 mm length by 3–5 mm width coronary EAT (cEAT) resection was performed over the middle segment of the left anterior descending artery (LAD) 15 mm distal to the left main bifurcation. Pigs recovered for 3 months on atherogenic diet. Intravascular ultrasound (IVUS) was performed in the LAD to quantify atheroma immediately after adipectomy and was repeated after recovery before sacrifice. Coronary wall biopsies were stained immunohistochemically for atherosclerosis markers and cytokines and cEAT was assayed for atherosclerosis-related genes by RT-PCR. Total EAT volume was measured by non-contrast CT before each IVUS. RESULTS: Circumferential plaque length increased (p < 0.05) in the proximal and distal LAD segments from baseline until sacrifice whereas plaque length in the middle LAD segment underneath the adipectomy site did not increase. T-cadherin, scavenger receptor A and adiponectin were reduced in the intramural middle LAD. Relative to control pigs without CAD, 11β-hydroxysteroid dehydrogenase (11βHSD-1), CCL19, CCL21, prostaglandin D(2) synthase, gp91phox [NADPH oxidase], VEGF, VEGFGR1, and angiotensinogen mRNAs were up-regulated in cEAT. EAT volume increased over 3 months. CONCLUSION: In pigs used as their own controls, resection of cEAT decreased the progression of CAD, suggesting that cEAT may exacerbate coronary atherosclerosis

Ursinus College Alumni Journal, November 1964

President\u27s letter • Charles David Mattern, 1907-1964: With tributes from some of his colleagues • Professor without portfolio: A portrait of the Rev. John Henry Augustus Bomberger, D. D., founder and first president of Ursinus College and School of Theology • The contemporary French literary scene • Quarter-century change . . . decade planning • Student facilities building construction moves steadily toward completion by mid-\u2765 • Joseph Chapline, \u2742, former computer expert builds organs - tells how and why • Larry Koch, \u2762, advances with Western Electric • Schellhase saga • Insurance executive, author - historian, two new members of Ursinus Board • The 1964 European travel seminar • Yale Press to publish Dr. Foster\u27s volumes • Four Ursinus alumni attend campus conference for furloughed missionaries • Pancoast, \u2737 elected to Pennsylvania House of Representatives • Collegeville comes to life as Ursinus students return • Founders Day focus on distinguished alumni • Remarks presenting portrait of President of Ursinus Board • Gutenberg Bible reproductions presented by Henry Pfeiffer, \u2748 • Loyalty Fund report: October 10, 1964 • Sports victories, crowning of Queen Jeanne, feature 1964 Homecoming Day at Ursinus • Twenty-three bear cubs in Ursinus freshman class • Frederick Wentz named college business manager • Another John H. A. Bomberger • Alumni news and notes • Weddings • Births • Necrology • Former Dean dead at 83 • Vice-president of directors dies unexpectedly November 1 • Former board member dies • Ursinus Women\u27s Club luncheon December 5 • Chef Colameco hurt in railroad wreck • You need a will . . . and Ursinus needs to be rememberedhttps://digitalcommons.ursinus.edu/alumnijournal/1081/thumbnail.jp

Soil Resources Area Affects Herbivore Health

Soil productivity effects nutritive quality of food plants, growth of humans and animals, and reproductive health of domestic animals. Game-range surveys sometimes poorly explained variations in wildlife populations, but classification of survey data by major soil types improved effectiveness. Our study evaluates possible health effects of lower condition and reproductive rates for wild populations of Odocoileus virginianus Zimmerman (white-tailed deer) in some physiographic regions of Mississippi. We analyzed condition and reproductive data for 2400 female deer from the Mississippi Department of Wildlife, Fisheries, and Parks herd health evaluations from 1991–1998. We evaluated age, body mass (Mass), kidney mass, kidney fat mass, number of corpora lutea (CL) and fetuses, as well as fetal ages. Region affected kidney fat index (KFI), which is a body condition index, and numbers of fetuses of adults (P ≤ 0.001). Region affected numbers of CL of adults (P ≤ 0.002). Mass and conception date (CD) were affected (P ≤ 0.001) by region which interacted significantly with age for Mass (P ≤ 0.001) and CD (P < 0.04). Soil region appears to be a major factor influencing physical characteristics of female deer