218 research outputs found
Note: Scale-free center-of-mass displacement correlations in polymer films without topological constraints and momentum conservation
We present here computational work on the center-of-mass displacements in
thin polymer films of finite width without topological constraints and without
momentum conservation obtained using a well-known lattice Monte Carlo algorithm
with chain lengths ranging up to N=8192. Computing directly the center-of-mass
displacement correlation function C_N(t) allows to make manifest the existence
of scale-free colored forces acting on a reference chain. As suggested by the
scaling arguments put forward in a recent work on three-dimensional melts, we
obtain a negative algebraic decay C_N(t) \sim -1/(Nt) for times t << T_N with
T_N being the chain relaxation time. This implies a logarithmic correction to
the related center-of-mass mean square-displacement h_N(t) as has been checked
directly
Constrained Dynamics of Universally Coupled Massive Spin 2-spin 0 Gravities
The 2-parameter family of massive variants of Einstein's gravity (on a
Minkowski background) found by Ogievetsky and Polubarinov by excluding lower
spins can also be derived using universal coupling. A Dirac-Bergmann
constrained dynamics analysis seems not to have been presented for these
theories, the Freund-Maheshwari-Schonberg special case, or any other massive
gravity beyond the linear level treated by Marzban, Whiting and van Dam. Here
the Dirac-Bergmann apparatus is applied to these theories. A few remarks are
made on the question of positive energy. Being bimetric, massive gravities have
a causality puzzle, but it appears soluble by the introduction and judicious
use of gauge freedom.Comment: 6 pages; Talk given at QG05, Cala Gonone (Italy), September 200
Crustal influx, indentation, ductile thinning and gravity redistribution in a continental wedge: Building a Moldanubian mantled gneiss dome with underthrust Saxothuringian material (European Variscan belt)
27 p.International audience[1] The contribution of lateral forces, vertical load, gravity redistribution and erosion to the origin of mantled gneiss domes in internal zones of orogens remains debated. In the Orlica-Snieznik dome (Moldanubian zone, European Variscan belt), the polyphase tectono-metamorphic history is initially characterized by the development of subhorizontal fabrics associated with medium- to high-grade metamorphic conditions in different levels of the crust. It reflects the eastward influx of a Saxothuringian-type passive margin sequence below a Teplá-Barrandian upper plate. The ongoing influx of continental crust creates a thick felsic orogenic root with HP rocks and migmatitic orthogneiss. The orogenic wedge is subsequently indented by the eastern Brunia microcontinent producing a multiscale folding of the orogenic infrastructure. The resulting kilometre-scale folding is associated with the variable burial of the middle crust in synforms and the exhumation of the lower crust in antiforms. These localized vertical exchanges of material and heat are coeval with a larger crustal-scale folding of the whole infrastructure generating a general uplift of the dome. It is exemplified by increasing metamorphic conditions and younging of 40Ar/39Ar cooling ages toward the extruded migmatitic subdomes cored by HP rocks. The vertical growth of the dome induces exhumation by pure shear-dominated ductile thinning laterally evolving to non-coaxial detachment faulting, while erosion feeds the surrounding sedimentary basins. Modeling of the Bouguer anomaly grid is compatible with crustal-scale mass transfers between a dense superstructure and a lighter infrastructure. The model implies that the Moldanubian Orlica-Snieznik mantled gneiss dome derives from polyphase recycling of Saxothuringian material
Biallelic MLH1 SNP cDNA expression or constitutional promoter methylation can hide genomic rearrangements causing Lynch syndrome
A positive family history, germline mutations in DNA mismatch repair genes, tumours with high microsatellite instability, and loss of mismatch repair protein expression are the hallmarks of hereditary non-polyposis colorectal cancer (Lynch syndrome). However, in ~10-15% of cases of suspected Lynch syndrome, no disease-causing mechanism can be detected
Lectures on the functional renormalization group method
These introductory notes are about functional renormalization group equations
and some of their applications. It is emphasised that the applicability of this
method extends well beyond critical systems, it actually provides us a general
purpose algorithm to solve strongly coupled quantum field theories. The
renormalization group equation of F. Wegner and A. Houghton is shown to resum
the loop-expansion. Another version, due to J. Polchinski, is obtained by the
method of collective coordinates and can be used for the resummation of the
perturbation series. The genuinely non-perturbative evolution equation is
obtained in a manner reminiscent of the Schwinger-Dyson equations. Two variants
of this scheme are presented where the scale which determines the order of the
successive elimination of the modes is extracted from external and internal
spaces. The renormalization of composite operators is discussed briefly as an
alternative way to arrive at the renormalization group equation. The scaling
laws and fixed points are considered from local and global points of view.
Instability induced renormalization and new scaling laws are shown to occur in
the symmetry broken phase of the scalar theory. The flattening of the effective
potential of a compact variable is demonstrated in case of the sine-Gordon
model. Finally, a manifestly gauge invariant evolution equation is given for
QED.Comment: 47 pages, 11 figures, final versio
Scale-free static and dynamical correlations in melts of monodisperse and Flory-distributed homopolymers: A review of recent bond-fluctuation model studies
It has been assumed until very recently that all long-range correlations are
screened in three-dimensional melts of linear homopolymers on distances beyond
the correlation length characterizing the decay of the density
fluctuations. Summarizing simulation results obtained by means of a variant of
the bond-fluctuation model with finite monomer excluded volume interactions and
topology violating local and global Monte Carlo moves, we show that due to an
interplay of the chain connectivity and the incompressibility constraint, both
static and dynamical correlations arise on distances . These
correlations are scale-free and, surprisingly, do not depend explicitly on the
compressibility of the solution. Both monodisperse and (essentially)
Flory-distributed equilibrium polymers are considered.Comment: 60 pages, 49 figure
A 115-bp MethyLight assay for detection of p16 (CDKN2A) methylation as a diagnostic biomarker in human tissues
<p>Abstract</p> <p>Background</p> <p><it>p16 </it>Methylation is a potential biomarker for prediction of malignant transformation of epithelial dysplasia. A probe-based, quantitative, methylation-specific PCR (MSP) called MethyLight may become an eligible method for detecting this marker clinically. We studied oral mucosa biopsies with epithelial dysplasia from 78 patients enrolled in a published 4-years' followup cohort, in which cancer risk for patients with <it>p16 </it>methylation-positive dysplasia was significantly higher than those without <it>p16 </it>methylation (by 150-bp MSP and bisulfite sequencing; +133 ~ +283, transcription starting site, +1). The <it>p16 </it>methylation status in samples (<it>N </it>= 102) containing sufficient DNA was analyzed by the 70-bp classic (+238 ~ +307) and 115-bp novel (+157 ~ +272) MethyLight assays, respectively.</p> <p>Results</p> <p><it>p16 </it>Methylation was detectable in 75 samples using the classic MethyLight assay. The methylated-<it>p16 </it>positive rate and proportion of methylated-<it>p16 </it>by the MethyLight in MSP-positive samples were higher than those in MSP-negative samples (positive rate: 37/44 vs. 38/58, <it>P</it>=0.035, two-sided; proportion [median]: 0.78 vs. 0.02, <it>P <</it>0.007). Using the published results of MSP as a golden standard, we found sensitivity, specificity, and accuracy for this MethyLight assay to be 70.5%, 84.5%, and 55.0%, respectively. Because amplicon of the classic MethyLight procedure only partially overlapped with the MSP amplicon, we further designed a 115-bp novel MethyLight assay in which the amplicon on the sense-strand fully overlapped with the MSP amplicon on the antisense-strand. Using the 115-bp MethyLight assay, we observed methylated-<it>p16 </it>in 26 of 44 MSP-positive samples and 2 of 58 MSP-negative ones (<it>P </it>= 0.000). These results were confirmed with clone sequencing. Sensitivity, specificity, and accuracy using the 115-bp MethyLight assay were 59.1%, 98.3%, and 57.4%, respectively. Significant differences in the oral cancer rate were observed during the followup between patients (≥60 years) with and without methylated-<it>p16 </it>as detected by the 115-bp MethyLight assay (6/8 vs. 6/22, P = 0.034, two-sided).</p> <p>Conclusions</p> <p>The 115-bp MethyLight assay is a useful and practical assay with very high specificity for the detection of <it>p16 </it>methylation clinically.</p
Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps
Background: Familial adenomatous polyposis (FAP) is a hereditary disorder characterized by polyposis along the gastrointestinal tract. Information on adenoma status below the duodenum has previously been restricted due to its inaccessibility in vivo. Ca
Three-Tiered Risk Stratification Model to Predict Progression in Barrett's Esophagus Using Epigenetic and Clinical Features
Barrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's esophagus has been debated because of the low incidence of esophageal adenocarcinoma in Barrett's esophagus. Moreover, high inter-observer and sampling-dependent variation in the histologic staging of dysplasia make clinical risk assessment problematic. In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency
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